Abstract
The study of transcriptional regulation often needs the integration of diverse yet independent data. In the present work, sequence conservation, prediction of transcription factor binding sites (TFBS) and gene expression analysis have been applied to the detection of putative transcription factor (TF) modules in the regulatory region of the FGFR3 oncogene. Several TFs with conserved binding sites in the FGFR3 regulatory region have shown high positive or negative correlation with FGFR3 expression both in urothelial carcinoma and in benign nevi. By means of conserved TF cluster analysis, two different TF modules have been identified in the promoter and first intron of FGFR3 gene. These modules contain activating AP2, E2F, E47 and SP1 binding sites plus motifs for EGR with possible repressor function.
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Bau, J., Cullell, M., SolĂ©-Casals, J. (2011). Integrative Analysis of the Regulatory Region of the FGFR3 Oncogene. In: Rocha, M.P., RodrĂguez, J.M.C., Fdez-Riverola, F., Valencia, A. (eds) 5th International Conference on Practical Applications of Computational Biology & Bioinformatics (PACBB 2011). Advances in Intelligent and Soft Computing, vol 93. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19914-1_27
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DOI: https://doi.org/10.1007/978-3-642-19914-1_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-19913-4
Online ISBN: 978-3-642-19914-1
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