Abstract
A number of studies in the last 20 years describe the development of several techniques to produce a great variety of nanoparticles applied as drug delivery systems, among them, the nanoprecipitation. However, no study analyzing the profitability of such systems was found in the literature. Therefore, in this work it is analyzed the profitability of a polymeric nanoproduct produced by the method of nanoprecipitation: the bezophenone-3, a sunscreen agent. Based on the laboratory procedures, 3 alternatives were proposed for the industrial production, including a static mixer and a ceramic membrane pre-filtration step. The simplified profitability analysis was done based on a methodology called Bare Module Cost. Its results showed that lowest sale prices were achieved when the particles are produced through the most simplified process and dividing the production in more batches per day. The procedure presented in this chapter is general and can be widely applied to other type of nanoparticles and processes.
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References
des Rieux, A., Fievez, V., Garinot, M., Schneider, Y.-J., Préat, V.: Nanoparticles as potential oral delivery systems of proteins and vaccines: A mechanistic approach. Journal of Controlled Release 116(1), 1–27 (2006)
Lademann, J., Weigmann, H., Rickmeyer, C., Barthelmes, H., Schaefer, H., Mueller, G., Sterry, W.: Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice. Skin Pharmacol. Appl. Skin Physiol. 12, 247–256 (1999)
Kuntsche, J., Bunjes, H., Fahr, A., Pappinen, S., Rönkkö, S., Suhonen, M., Urtti, A.: Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model. International Journal of Pharmaceutic 354(1-2), 180–195 (2008)
Zhang, L.W., Yu, W.W., Colvin, V.L., Monteiro-Riviere, N.A.: Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicology and Applied Pharmacology 228(2), 200–211 (2008)
Coulman, S.A., Anstey, A., Gateley, C., Morrissey, A., McLoughlin, P., Allender, C., Birchall, J.C.: Microneedle mediated delivery of nanoparticles into human skin. International Journal of Pharmaceutics 366(1-2), 190–200 (2009)
Fessi, H., Puisieux, F., Devissaguet, J.P., Ammoury, N., Benita, S.: Nanocapsule formation by interfacial polymer deposition following solvent displacement. International Journal of Pharmaceutics 55, R1–R4 (1989)
Guterres, S.S., Fessi, H., Barratt, G., Devissaguet, J.P., Puisieux, F.: Poly (DL-lactide) nanocapsules containing diclofenac: I. Formulation and stability study. International Journal of Pharmaceutics 113(1), 57–63 (1995)
Thioune, O., Fessi, H., Devissaguet, J.P., Puisieux, F.: Preparation of pseudolatex by nanoprecipitation: Influence of the solvent nature on intrinsic viscosity and interaction constant. International Journal of Pharmaceutics 146(2), 233–238 (1997)
Govender, T., Stolnik, S., Garnett, M.C., Illum, L., Davis, S.S.: PLGA nanoparticles prepared by nanoprecipitation: drug loading and release studies of a water soluble drug. Journal of Controlled Release 57(2), 171–185 (1999)
Chorny, M., Fishbein, I., Danenberg, H.D., Golomb, G.: Lipophilic drug loaded nanospheres prepared by nanoprecipitation: effect of formulation variables on size, drug recovery and release kinetics. Journal of Controlled Release 83(3), 389–400 (2002)
Turton, R., Bailie, R.C., Whiting, W.B., Shaeiwits, J.A.: Analysis, Synthesis, and Design of Chemical Processes, 2nd edn. Prentice-Hall, New Jersey (2003)
Paese, K.: Desenvolvimento tecnológico, estudo da fotoestabilidade e avaliação da permeação cutânea in vitro da benzofenona-3 a partir de nanocápsulas poliméricas incorporadas em diferentes veículos semi-sólidos. UFRGS, Porto Alegre (2008)
Guterres, S.S., Muller, C.R., Bassani, V.L., Pohlmann, A.R., Dalla Costa, T.C.T.: Processo de secagem de suspensões coloidais de nanocápsulas e nanoesferas poliméricas por aspersão, PI9906081-7 A2 (1999)
Wagner, J.: Membrane Filtration Handbook Practical Tips and Hints. Osmonics, 129 (2001)
CEPCI. Chemical Engineering Plant Cost Index. Chemical Engineering 116, 72 (2009)
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Trierweiler, L.F., Trierweiler, J.O. (2011). Industrial Production of Polymeric Nanoparticles: Alternatives and Economic Analysis. In: Beck, R., Guterres, S., Pohlmann, A. (eds) Nanocosmetics and Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19792-5_6
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DOI: https://doi.org/10.1007/978-3-642-19792-5_6
Publisher Name: Springer, Berlin, Heidelberg
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