Skip to main content

A Refractive Index Sensor Based on Microinterferometric Backscatter

  • Conference paper
Future Intelligent Information Systems

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 86))

Abstract

Refractive index (RI) detection is a common technique used in chemical and biochemical analysis. Rapid monitoring and refractive detection of ultra small volume samples are in great demand. However, it is still a significant challenge for highly precise and miniature detectors to measure ultra small volume samples. This paper will present a flexible method to record the interference fringes which are caused by backscatter with a new linear CCD; furthermore, it will get the information of refractive index by tracking the displacement of fringes with FFT analysis. With this approach, we have been able to obtain detection limits of 2.44×10− 7 \(\triangle\)n, corresponding to 1.37×10− 6 g/mL.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 259.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 329.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Valcarcel, M., Cardenas, S.: We Need Reliable Ways to Bypass Preliminary Operations in (Bio) Chemical Measurement. Anal. Chem. 21, 211–212 (2002)

    Google Scholar 

  2. Markov, D., Begari, D., Bornhop, D.J.: Breaking the 10− 7 Barrier for RI Measurements in Nanoliter Volumes. Anal. Chem. 74, 5438–5441 (2002)

    Article  Google Scholar 

  3. Bornhop, D.J.: Microvolume Index of Refraction Determinations by Interferometric Back-scatter. Appl. Opt. 34, 3234–3239 (1995)

    Article  Google Scholar 

  4. Markov, D.A., Swinney, K., Bornhop, D.J.: Label-free Molecular Interaction Determinations with Nanoscale Interferometry. Journal of the American Chemical Society 126, 16659–16664 (2004)

    Article  Google Scholar 

  5. Bornhop, D.J., Latham, J.C., Kussrow, A., Markov, D.A., Jones, R.D.: Free-solution, Label-free Molecular Interactions Studied by Backscattering Interferometry. Science 317, 1732–1736 (2007)

    Article  Google Scholar 

  6. Phayre, A.N., Hartley, N.K., Hayes, M.A.: Microdevices for Biological Analyses Recent Advances and Directions for the Future. Journal of the Association for Laboratory Automation 5, 78–82 (2000)

    Article  Google Scholar 

  7. Hendra, J., Tarigan, N.P., Christopher, K., Darryl, J., Bornhop, D.J.: Capillary-Scale Refractive Index Detection by Interferometric Backscatter. Anal. Chem. 68, 1762–1770 (1996)

    Article  Google Scholar 

  8. Wang, Z., Darryl, J., Bornhop, D.J.: Dual-Capillary Backscatter Interferometry for High-Sensitivity Nanoliter-Volume Refractive Index Detection with Density Gradient Compensation. Anal. Chem. 77, 7872–7877 (2005)

    Article  Google Scholar 

  9. Sorensen, H.S., Pranov, H., Larsen, N.B., Bornhop, D.J., Andersen, P.E.: Absolute Refracttive Index Determination by Microinterferometric Backscatter Detection. Anal. Chem. 75, 1946–1953 (2003)

    Article  Google Scholar 

  10. Swinney, K., Markov, D.A., Darryl, J., Bornhop, D.J.: Ultrasmall Volume Refractive Index Detection Using Microinterferometry. American Institute of Physics 71, 2684–2693 (2000)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Wang, H., Ding, Y. (2011). A Refractive Index Sensor Based on Microinterferometric Backscatter. In: Zeng, D. (eds) Future Intelligent Information Systems. Lecture Notes in Electrical Engineering, vol 86. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19706-2_56

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-19706-2_56

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-19705-5

  • Online ISBN: 978-3-642-19706-2

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics