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Corticotropin Signaling System in the Skin

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Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System

Part of the book series: Advances in Anatomy, Embryology and Cell Biology ((ADVSANAT,volume 212))

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Abstract

Corticotropin-Releasing Factor (CRF), a 41 amino acid long hypothalamic neuropeptide discovered by Vale and Rivier (Spiess et al. 1981; Vale et al. 1981), and related urocortin (Urc1-3) are brain neuropeptides that regulate behavioral, autonomic, endocrine, reproductive, metabolic, and immune functions (Grammatopoulos and Chrousos 2002; Hillhouse et al. 2002; Perrin and Vale 1999). In peripheral tissues, they act as local immunomodulators with predominantly proinflammatory actions (Hasse et al. 2007; Slominski 2003b; Slominski et al. 2006c; Theoharides and Cochrane 2004) as well as they directly regulate cardiovascular, gastrointestinal, reproductive, and gestational activities (Hillhouse et al. 2002). These neuropeptides exert their regulatory activities via interaction with CRF receptors, CRF1 and CRF2, which were cloned and initially characterized by Vale’s group and others (Grammatopoulos and Chrousos 2002; Hillhouse and Grammatopoulos 2006; Hillhouse et al. 2002; Perrin and Vale 1999; Slominski et al. 2001).

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, and Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

    Andrzej T. Slominski

  2. Department of Histology, Medical University of Gdansk, Gdansk, Poland

    Michal A. Zmijewski

  3. Department of Pathology and Laboratory Medicine, University of Tennessee Health Sciences Center, Memphis, TN, USA

    Cezary Skobowiat & Blazej Zbytek

  4. University of Tennessee Health Science Center, Memphis, TN, USA

    Radomir M. Slominski

  5. Jagiellonian University Medical College, Krakow, Poland

    Radomir M. Slominski

  6. Department of Pharmacology, University of Tennessee Health Science Center, Memphis, TN, USA

    Jeffery D. Steketee

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  1. Andrzej T. Slominski
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  2. Michal A. Zmijewski
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  3. Cezary Skobowiat
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Correspondence to Andrzej T. Slominski .

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Slominski, A.T., Zmijewski, M.A., Skobowiat, C., Zbytek, B., Slominski, R.M., Steketee, J.D. (2012). Corticotropin Signaling System in the Skin. In: Sensing the Environment: Regulation of Local and Global Homeostasis by the Skin's Neuroendocrine System. Advances in Anatomy, Embryology and Cell Biology, vol 212. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19683-6_5

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