Abstract
Small-angle X-ray scattering (SAXS) is employed to establish the structure of a self-assembled lipid/water system formed in excess aqueous phase by pharmaceutical-grade glycerol monooleate (GMO). A nonionic guest component (octyl glucoside) is incorporated with the purpose to study the swelling of the structure under full hydration. Small-angle neutron scattering (SANS) is used for characterization of the micellar properties of the octyl glucoside amphiphile and glycerol monooleate. The obtained SAXS and SANS patterns indicate a sponge-type supramolecular organization of the investigated lipid material. Their analysis allows determination of the average cell-cell distances in the bicontinuous bilayer sponge that are essential for the encapsulation of biomolecules and drugs. In the presence of the guest octyl glucoside (OG) the average size of the sponge cells is increased by about 14%. This would be an advantageous feature for the application of sponge-type liquid crystalline carriers as protein drug delivery vehicles, nanostructured bioreactors, and peptide-encapsulating fluid nanomaterials.
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Acknowledgment
This paper is dedicated to the memory of Dr. Michel OLLIVON, a Research Director at CNRS. The research project has been supported by the European Commission under the 6th Framework Programme through the Key Action: Strengthening the European Research Area, Research Infrastructures. Contract n°: RII3-CT-2003-505925 (EU user's access programme NMI3).
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Angelova, A. et al. (2011). Swelling of a Sponge Lipid Phase via Incorporation of a Nonionic Amphiphile: SANS and SAXS Studies. In: Starov, V., Procházka, K. (eds) Trends in Colloid and Interface Science XXIV. Progress in Colloid and Polymer Science, vol 138. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19038-4_1
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