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Lipoprotein Transport

  • Chapter
Transgenic Models in Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 159))

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Abstract

Transgenic animals have become an important tool that has helped to shape our current understanding of the mechanisms of lipoprotein metabolism. They have also proved invaluable for the evaluation of therapeutic strategies directed against disorders of lipid homeostasis and related diseases such as atherosclerosis, obesity, and Alzheimer’s disease. In this chapter, we will briefly outline the biochemical and physiological basis of cellular and systemic lipoprotein metabolism and review selected examples how genetically modified animals have aided us in dissecting the molecular function of the genes that regulate lipoprotein transport in the context of the whole organism.

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Authors and Affiliations

  1. Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX, 75390-9046, USA

    H. H. Bock, P. May & J. Herz

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  1. H. H. Bock
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  2. P. May
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  3. J. Herz
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  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Stefan Offermanns

  2. Institut für Pharmakologie und Toxikologie der Universität, Versbacher Straße 9, 97078, Germany

    Lutz Hein

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Bock, H.H., May, P., Herz, J. (2004). Lipoprotein Transport. In: Offermanns, S., Hein, L. (eds) Transgenic Models in Pharmacology. Handbook of Experimental Pharmacology, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18934-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-18934-0_14

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