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Novel Mouse Models in Biomedical Research: The Power of Dissecting Pathways by Quantitative Control of Gene Activities

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Transgenic Models in Pharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 159))

Abstract

The last decade has seen significant progress in the development and refinement of genetic approaches applicable to the mouse, making this animal the prime organism for the study of mammalian genetics. Particularly, the potential to control individual gene activities in a temporally defined and tissuespecific manner has allowed us to dissect gene functions and pathways in vivo with unprecedented precision, yielding exciting new insights into such complex biological processes as development, behavior, and disease. For biomedical research, the new approaches of mouse molecular genetics open up new perspectives for modeling human diseases. Particularly methods that allow quantitative and reversible control over disease genes will enable the experimenter to not only study the onset of a disease and its progression but also to examine its potential reversibility and to investigate mechanisms of disease regression. In this chapter, we summarize the principle of Tet regulation as a paradigm for a reversible gene control system and we briefly discuss Tet regulation-based mouse models of human diseases in the area of cancer as well as of neurodegenerative and cardiac diseases.

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  1. Zentrum fuer Molekulare Biologie (ZMBH), Universitaet Heidelberg, Im Neuenheimer Feld 282, 69120, Heidelberg, Germany

    S. Berger & H. Bujard

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  1. S. Berger
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  1. Pharmakologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 366, 69120, Heidelberg, Germany

    Stefan Offermanns

  2. Institut für Pharmakologie und Toxikologie der Universität, Versbacher Straße 9, 97078, Germany

    Lutz Hein

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Berger, S., Bujard, H. (2004). Novel Mouse Models in Biomedical Research: The Power of Dissecting Pathways by Quantitative Control of Gene Activities. In: Offermanns, S., Hein, L. (eds) Transgenic Models in Pharmacology. Handbook of Experimental Pharmacology, vol 159. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18934-0_1

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  • DOI: https://doi.org/10.1007/978-3-642-18934-0_1

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