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Transcription Factors in the Control of Tumor Development and Progression by TGF-β Signaling

  • Chapter
Transcription Factors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 166))

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Abstract

Transforming growth factor-β (TGF-β) is a cytokine that controls homeostasis and/or remodeling in many tissues, including most if not all epithelial tissues. These functions are mediated by the regulation of diverse cellular processes, such as cell proliferation, cell death or survival, cell migration and invasion, and cell differentiation. In human cancers TGF-β functions as a tumor suppressor in early stages, but converts into a tumor promoter in later stages of the disease. Understanding the molecular basis for this switch in TGF-β function is highly relevant, if TGF-β is to be exploited as a target in cancer therapy. Since most of the cellular TGF-β responses characterized to date are mediated by the transcriptional control of direct target genes of TGF-β signaling, this inevitably entails the analysis of the transcriptional mediators of TGF-β function in normal cells as well as tumor cells of different malign ant potential. This review will discuss some of the important transcriptional mediators involved, with emphasis on the mammary epithelium as an example of the complex role of TGF-β in regulating normal and tum origenic tissues.

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Authors and Affiliations

  1. Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine, One Gustave Levy Place, Box 1130, New York, NY, 10029, USA

    I. Timokhina, J. Lecanda & M. Kretzschmar

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  1. I. Timokhina
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  2. J. Lecanda
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  3. M. Kretzschmar
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Correspondence to M. Kretzschmar .

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  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Manfred Gossen

  2. atugen AG, Robert-Rössle-Strasse 10, 13125, Berlin, Germany

    Jörg Kaufmann

  3. Department of Biochemistry and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

  4. Graduate Program in Cell and Molecular Biology, Michigan State University, 510 Biochemistry Building, East Lansing, MI, 48824-1319, USA

    Steven J. Triezenberg (Associate Director) (Associate Director)

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© 2004 Springer-Verlag

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Timokhina, I., Lecanda, J., Kretzschmar, M. (2004). Transcription Factors in the Control of Tumor Development and Progression by TGF-β Signaling. In: Gossen, M., Kaufmann, J., Triezenberg, S.J. (eds) Transcription Factors. Handbook of Experimental Pharmacology, vol 166. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18932-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-18932-6_6

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