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Tachykinins pp 141–172Cite as

The Mechanism and Function of Agonist-Induced Trafficking of Tachykinin Receptors

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 164))

Abstract

Biological responses to agonists of G-protein coupled receptors are regulated by control of the interactions of receptors with signaling proteins and through control of the levels of receptors that are present at the cell surface. Agonist binding to receptors induces conformational changes that stabilize interaction between receptors and heterotrimeric G-proteins, which signal to a large number of pathways. This activation is often immediately followed by a series of events beginning with receptor phosphorylation that serve to uncouple receptors from heterotrimeric G-proteins and thereby terminate signaling. Another mechanism of control involves processes that regulate the trafficking of receptors to and from the cell surface. The capacity of cells to respond to agonists is critically dependent on the presence of receptors at the surface of cells, where they can bind to lipophobic agonists in the extracellular fluid and interact with heterotrimeric G-proteins and related signaling molecules that are often clustered at the plasma membrane or in microdomains within the cell. The presence of receptors at the plasma membrane is a balance between the removal of receptors by endocytosis, which is often regulated by binding to agonists, and replenishment by recycling of internalized receptors or by mobilization of stored or freshly synthesized receptors. This chapter focuses on our understanding of these mechanisms that control signaling of the neuropeptide SP and its neurokinin receptors.

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Abbreviations

β2AR:

β2-Adrenergic receptor

ERK:

Extracellular signal response kinases

GABA:

Gamma-aminobutyric acid

GFP:

Green fluorescent protein

GPCR:

G-protein-coupled receptor

GRK:

G-protein receptor kinase

MAP kinase:

Mitogen-activated protein kinase

NKA:

Neurokinin A

NKR:

(NK1R, NK2R, NK3R) tachykinin NK1, NK2 and NK3 receptors

NMDA:

N-methyl-D-aspartate

PKC:

Protein kinase C

SP:

Substance P

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Authors and Affiliations

  1. Departments of Surgery and Physiology, University of California, Room C317, UCSF, 513 Parnassus Avenue, San Francisco, CA, 94143-0660, USA

    D. Roosterman & N. W. Bunnett

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  1. D. Roosterman
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  2. N. W. Bunnett
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  1. Department of Experimental and Clinical Pharmacology, Medical University of Graz, Universitätsplatz 4, 8010, Graz, Austria

    Peter Holzer (Professor) (Professor)

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© 2004 Springer-Verlag Berlin Heidelberg

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Roosterman, D., Bunnett, N.W. (2004). The Mechanism and Function of Agonist-Induced Trafficking of Tachykinin Receptors. In: Holzer, P. (eds) Tachykinins. Handbook of Experimental Pharmacology, vol 164. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18891-6_5

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  • DOI: https://doi.org/10.1007/978-3-642-18891-6_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62342-4

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