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Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation

  • Chapter
Phosphoinositides in Subcellular Targeting and Enzyme Activation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 282))

Abstract

Abstract Cells of the innate immune system engulf invading microorganisms into plasma membrane-derived vacuoles called phagosomes. Newly formed phagosomes gradually acquire microbicidal properties by a maturation process which involves sequential and coordinated rounds of fusion with endomembranes and concomitant fission. Some pathogens interfere with this maturation sequence and thereby evade killing by the immune cells, managing to survive intracellularly as parasites. Phosphoinositides seem to be intimately involved in the processes of phagosome formation and maturation, and initial observations suggest that the ability of some microorganisms to survive intracellularly is associated with alterations in phosphoinositide metabolism. This chapter presents a brief overview of phosphoinositides in cells of the immune system, their metabolism in the context of phagocytosis and phagosome maturation and their possible derangements during infectious pathogenesis.

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  1. Programme in Cell Biology, Hospital for Sick Children and the Department of Biochemistry, University of Toronto, Toronto, Ontario, M5G 1X8, Canada

    R. J. Botelho, C. C. Scott & S. Grinstein

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  1. R. J. Botelho
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  2. C. C. Scott
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  3. S. Grinstein
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  1. Department of Biochemistry, The Norwegian Radium Hospital, Montebello, 0310, Oslo, Norway

    Harald Stenmark

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Botelho, R.J., Scott, C.C., Grinstein, S. (2004). Phosphoinositide Involvement in Phagocytosis and Phagosome Maturation. In: Stenmark, H. (eds) Phosphoinositides in Subcellular Targeting and Enzyme Activation. Current Topics in Microbiology and Immunology, vol 282. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18805-3_1

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