Zusammenfassung
Bis vor kurzem wurde die Diagnose einer Osteoporose erst mit Auftreten schmerzhafter Frakturen gestellt. Mit wachsendem Bewusstsein für gesunde Lebensweise wird klar, dass das Erkennen und Vermeiden von Risikofaktoren helfen kann, viele chronische Erkrankungen zu verhüten. Eine 50 Jahre alte postmenopausale Frau, die im Rahmen der jährlichen Vorsorgeuntersuchung zu ihrem Arzt geht, kann heute erwarten, dass ihr Blutdruck gemessen, ihr Cholesterinspiegel bestimmt und eine Mammographie durchgeführt wird — das ist gute medizinische Praxis. Zu einer umfassenden Vorsorgeuntersuchung müssten heutzutage auch das Abfragen der Risikofaktoren für Osteoporose und die Knochendichtemessung gehören. Untersuchungen haben gezeigt, dass eine niedrige Knochendichte das Frakturrisiko genauer vorhersagt als ein erhöhter Cholesterinspiegel den Herzinfarkt oder ein hoher Blutdruck den Schlaganfall. Wir wissen heute, dass viele genetische und erworbene Faktoren für die Entwicklung der Osteoporosen verantwortlich sind. Ferner wurde gezeigt, dass eine niedrige Knochendichte mit einem geringeren Brustkrebsrisiko verknüpft ist: stimulierende Effekte des Östrogens auf den trabekulären Knochen wie auf das Mammagewebe mögen für diese Korrelation verantwortlich sein. Eine Studie an Hämodialysepatienten hat nachgewiesen, dass Veränderungen der Knochendichte mit einer Progression der Arteriosklerose korrelieren.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Literatur
Ahlborg H, Johnell O, Turner C et al. (2003) DeBone loss and bone size after menopause. Engl J Med 349:327–334
Ammann P, Rizzoli R (2003) Bone strength and its determinants. 14(Suppl3): 13–18
Biolo G, Heer M, Narici M, Strollo F (2003) DeMicrogravity as a model of ageing. Curr Opin Clin Nutr Metab Care 6:3–7
Bone C, Einhorm T (2003) DeOverview of osteoporosis: pathophysiology and determinants of bone strength. Eur Spine J 12:90–96
Chapurlat R, Bauer D, Nevitt M et al. (2003) DeIncidence and risk factors for a second hip fracture in elderly women. The study of osteoporotic fractures. Osteoporos Int 14:130–136
Chapuy M, Arlot M, Duboeuf F et al. (1992) DeVitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 327:1637–1642
Charles P (1992) DeCalcium absorption and calcium bioavailability. J Intern Med 231:161–168
Cohen A, Shane E (2003) DeOsteoporosis after solid organ and bone marrow transplantation. Osteoporos Int 14:617–630
Cummings S (1996) DeTreatable and untreatable risk factors for hip fracture. Bone 18:165–167
Cummings S, Black D, Rubin S (1989) DeLifetime risks of hip, Colles' or vertebral fracture and coronary heart disease among white postmenopausal women. Arch Intern Med 149:2445–2449
Ettinger M (2003) DeAging bone and osteoporosis: strategies for preventing fractures in the elderly. Arch Intern Med 163:2237–2246
Fitzpatrick L, Heaney R (2003) DeGot soda? J Bone Miner Res 18:1570–1571
Fleisch H (2001) DeCan bisphosphonates be given to patients with fractures? J Bone Miner Res 16:437–440
Frank G (2003) DeRole of estrogen and androgen in pubertal skeletal physiology. Med Pediatr Oncol 41:217–221
Gerdhem P, Obrant K (2002) DeEffects of cigarette-smoking on bone mass as assessed by dual-energy X-ray absorptiometry and ultrasound. Osteoporos Int 13:933–936
Gerdhem P, Akesson K, Obrant K (2003) DeEffect of previous and present physical activity on bone mass in elderly women. Osteoporos. Int 14:208–212
Gourlay M, Richy F, Reginster J (2003) DeStrategies for the prevention of hip fractures. Am J Med 115:309–317
Gregg E, Pereira M, Caspersen C (2000) DePhysical activity, falls, and fractures among older adults: a review of the epidemiologic evidence. J Am Geriatr Soc 48:883–893
Grisso J, Kelsey J, Strom B et al. (1991) DeRisk factors for falls as a cause of hip fracture in women. N Engl J Med 324:1326–1331
Haentjens P, Autier P, Collins J et al. (2003) DeColles fracture, spine fracture, and subsequent risk of hip fracture in men and women. J Bone Joint Surg 85A:1936–1943
Hughes-Fulford M, Tjandrawinata R, Fitzgerald J et al. (1998) DeEffects of microgravity on osteoblast growth. Gravit Space Biol Bull 11:51–60
Kemmler W, Engelke K, Weineck J et al. (2003) DeThe Erlangen fitness osteoporosis prevention study: a controlled exercise trial in early postmenopausal women with low bone density-first-year results. Arch Phys Med Rehabil 84:673–682
Klift M, Laet C, Coebergh J et al. (2003) DeBone mineral density and the risk of breast cancer: the Rotterdam study. Bone 32:211–216
Krall E, Dawson-Hughes B (1991) DeSmoking and bone loss among postmeenopausal women. J Bone Miner Res 6:331–338
Kudlacek S, Freudenthaler O, Weissboeck H et al. (2003) DeLactose intolerance: a risk factor for reduced bone mineral density and vertebral fractures? J Gastroenterol 37:1014–1019
Lips P (2001) DeVitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocrine Reviews 22:477–501
McGartland C, Robson P, Murray L et al. (2003) DeCarbonated soft drink consumption and bone mineral density in adolescence: the Northern Ireland Young Hearts Project. J Bone Miner Res 18:1563–1569
Perese E, Perese K (2003) DeHealth problems of women with severe mental illness. J Am Acad Nurse Pract 15:212–219
Ralston S (2003) DeGenetic determinants of susceptibility to osteoporosis. Curr Opin Pharmacol 3:286–290
Recker R, Hinders S, Davies K et al. (1996) DeCorrecting calcium nutritional deficiency prevents spine fractures in elderly women. J Bone Miner. Res 11:1961–1966
Rehman O, Lane N (2003) DeEffect of glucocorticoids on bone density. Med Pediatr Oncol 41:212–216
Reid I, Ames R, Evans M, Gamble G, Sharpe S (1995) DeLong-term effect of calcium supplementation on bone loss and fracture in postmenopausal women: a randomized controlled trial. Am J Med 98:331–335
Richmond J, Aharonoff G, Zuckerman J, Koval K (2003) DeMortality risk after hip fracture. J Orthop Trauma 17:2–5
Richy F, Bousquet J, Eherlich G et al. (2003) DeInhaled corticosteroid effects on bone in asthmatic and COPD patients: a quantitative systematic study. Osteoporos Int 14:179–190
Sambrook P, Kotowicz M, Nash P et al. (2003) DePrevention and treatment of glucocorticoid-induced osteoporosis: a comparison of Kalzitriol, vitamin D plus calcium and alendronate plus calcium. J None Miner Res 18:919–924
Schuh T, Lyles K (2003) DeOsteoporosis considerations in the frail elderly. Curr Opin Rheumatol 15:481–486
Shabat S, Gepstein R, Mann G et al. (2003) DeThe second hip fracture — an analysis of 84 elderly patients. J Orthop Trauma 17:613–617
Siebler T, Shalet S, Robson H (2002) DeEffects of chemotherapy on bone metabolism and skeletal growth. Horm Res 58(Suppl1):80–85
Sinake M (2003) DeCritical appraisal of physical rehabilitation measures after osteoporotic vertebral fracture. Osteoporos Int 14:773–779
J, Kroger H, Honkanen R et al. (2003) DeSmoking may impair the bone protective effects of nutritional calcium: a population-based approach. J Bone Miner Res 18:1036–1042
Smith I, Dowsett M (2003) DeAromatase inhibitors in breast cancer. N Engl J Med 348:2431–2442
Smith S, Heer M (2002) DeCalcium and bone metabolism during space flight. Nutrition 18:849–852
Sowers M, Crutchfield M, Jannausch M et al. (1991) DeA prospective evaluation of bone mineral changee in pregnancy. Obstet Gynecol 77:841–845
Stone K, Seeley D, Lui L et al. (2003) DeBMD at multiple sites and risk of fracture of multiple types: long-term results from the study of osteoporotic fractures. J Bone Miner Res 18:1947–1954
Van Staa T, Leufkens H, Cooper C (2002) DeDoes a fracture at one site predict later fractures at other sites? A british cohort study. Osteoporos Int 13:624–629
Van Staa T, Leufkens H, Cooper C (2002) DeThe epidemiology of corticosteroidinduced osteoporosis: a meta-analysis. Osteoporos Int 13:777–787
Verrotti A, Greco R, Latini G et al. (2002) DeIncreased bone turnover in prepubertal, pubertal and postpubertal patients receiving carbamazepine. Epilepsia 43:1488–1492
Women's Health Initiative Group (2002) DeRisks and benefits of estrogen plus progestin in healthy postmenopausal women. JAMA 288:321–333
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Bartl, R., Bartl, C. (2004). Risikofaktoren. In: Osteoporose-Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18792-6_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-18792-6_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20892-1
Online ISBN: 978-3-642-18792-6
eBook Packages: Springer Book Archive