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Functional Brain Imaging and Large Animal Research

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Nuclear Medicine in Psychiatry

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Abstract

In this chapter a review will be given on brain functional imaging research on large animals in order to contribute to a better understanding of human neuropsychiatric disorders and explore treatment options. In general, smaller laboratory animals such as mice and rats have been extensively used. Nevertheless, the utilization of larger animals has definite advantages because of their larger brain size, omitting the need for dedicated equipment (micro-PET or -SPET). First, large animal models, usually primate models, are used to obtain information on the pharmacokinetics and pharmacodynamics of newly developed drugs and the dosage at which maximal response and least side effects occur. They are also used to investigate normal physiology and interaction of several neurotransmitter systems and the effects of substances of abuse on brain function and chemistry. Finally, models of animal behaviour, both in natural conditions or after artificially (chemically or surgically) induced lesions, are used to enlighten the biological base of several human brain disorders.

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Authors and Affiliations

  1. Department of Medical Imaging, Faculty of Veterinary Medicine, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kathelijne Peremans

  2. Department of Psychiatry and Medical Psychology, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Kurt Audenaert

  3. Department of Medical Imaging, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    F. Verschooten

  4. Division of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Andreas Otte & Rudi Dierckx

  5. Laboratory for Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, 9000, Gent, Belgium

    Guido Slegers

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  2. Kurt Audenaert
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  3. F. Verschooten
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  4. Andreas Otte
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  5. Guido Slegers
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  6. Rudi Dierckx
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Editor information

Editors and Affiliations

  1. Division of Nuclear Medicine, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Andreas Otte  & Rudi A. Dierckx  & 

  2. University Department of Psychiatry, University Hospital Ghent, De Pintelaan 185, 9000, Gent, Belgium

    Kurt Audenaert  & Kees van Heeringen  & 

  3. Department of Medical Imaging Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820, Merelbeke, Belgium

    Kathelijne Peremans

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© 2004 Springer-Verlag Berlin Heidelberg

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Peremans, K., Audenaert, K., Verschooten, F., Otte, A., Slegers, G., Dierckx, R. (2004). Functional Brain Imaging and Large Animal Research. In: Otte, A., Audenaert, K., Peremans, K., van Heeringen, K., Dierckx, R.A. (eds) Nuclear Medicine in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18773-5_9

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  • DOI: https://doi.org/10.1007/978-3-642-18773-5_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62287-8

  • Online ISBN: 978-3-642-18773-5

  • eBook Packages: Springer Book Archive

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