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Neuroreceptor Imaging Studies and the Mechanism of Action of Antipsychotic Drugs

  • Valeria Bigliani
  • Lyn S. Pilowsky
  • Geraldo Busatto
Chapter
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Abstract

Neuroimaging techniques have brought fundamental contributions to the neurosciences, allowing the study of the living human brain and the effects of the drugs in it. This is specially relevant in psychiatry, as psychosis particularly affects higher human functions such as language and emotions. PET and SPET studies not only confirmed in vitro studies correlating dopamine with antipsychotic action, but also have extended knowledge in the field. These techniques were able to link specific dopamine receptors with their localization in the brain, their affinity, and the relation with clinical effects: side effects. They also made it possible to investigate the involvement of other neurotransmitter systems, such as the serotonergic, in the mechanism of action of antipsychotic drugs. PET and SPET neuroimaging is becoming a requirement at all stages of new drug development. The study of the mechanism of action of the existent antipsychotic drugs with neuroimaging techniques is vital for the process of designing better and less toxic drugs for this devastating illness.

Keywords

Positron Emission Tomography Antipsychotic Drug Receptor Occupancy Single Photon Emission Tomography Atypical Antipsychotic Drug 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Valeria Bigliani
    • 1
  • Lyn S. Pilowsky
    • 2
  • Geraldo Busatto
    • 1
  1. 1.Institute of Nuclear MedicineSao PauloBrazil
  2. 2.Institute of PsychiatryLondonUK

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