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Functional Brain Imaging in Court

  • Sukhi Shergill
  • Kris H. Naudts
  • J. Gunn
Chapter
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Abstract

Nuclear medicine CNS studies, SPECT and PET, are increasingly used as a tool in forensic medicine. The mental disorders which attract most legal attention are those where a connection between an injurious stimulus and the disorder is likely to exist, as for instance in posttraumatic brain injury or post-traumatic stress disorder. However, even with these disorders with a much clearer aetiology, the same brain changes are not clear in all subjects. Thus, functional neuro-imaging cannot safely be used to make a diagnosis of a psychiatric disorder or indicate the presence or absence of psychiatric symptoms. It can be used to support a case which has other evidence, so evidence of functional abnormality in a brain region shown to be abnormal on a structural brain scan would provide useful additional information.

Keywords

Traumatic Brain Injury Single Photon Emission Compute Tomography Posttraumatic Stress Disorder Hippocampal Volume Functional Brain Image 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bavetta S, Nimmon CC, White J, McCabe J, Huneidi AH, Bomanji J, Birkenfeld B, Charlesworth M, Britten KE, Greenwood RJ (1994) A prospective study comparing SPET with MRI and CT as prognostic indicators following severe closed head injury. Nucl Med Commun 15:961–968PubMedCrossRefGoogle Scholar
  2. Bremner JD, Randall P, Scott TM et al (1995) MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder. Am J Psychiatry 152:973–981PubMedGoogle Scholar
  3. Brown B, Tarr S (1997) Does your PET bite? The misapplication of brain scans in toxic tort litigation. For the Defense 39:8–16Google Scholar
  4. Catafau AM, Carrio I (1999) The end of the ‘decade of the brain’: reflections on European neuroimaging and implications of the EANM Congress. Eur J Nucl Med 26:955–957CrossRefGoogle Scholar
  5. Daubert vs Merrell Dow Pharmaceuticals (1993) US Supreme Court. 113 Supreme Court: 2786. US courts sentences available at web page: http://www.findlaw.com/casecode/supreme.html
  6. Flower D (2000) SPECT: respect or suspect? Health 12:4–5Google Scholar
  7. Gurvitis TV, Shenton ME, Hokama H, Ohta H, Lasho NB, Gilbertson MW, Orr SP, Kikinis R, Jolesz FA, McCarley RW, Pitman RK (1996) Magnetic resonance imaging study of hippocampal volume in chronic combat-related posttraumatic stress disorder. Biol Psychiatry 40:1091–1099CrossRefGoogle Scholar
  8. Jacobs A, Put E, Ingels M, Bossuyt A (1994) Prospective evaluation of technetium-99m-HMPAO SPECT in mild and moderate traumatic brain injury. J Nucl Med 35:942–947PubMedGoogle Scholar
  9. Lass P, Piskunowicz M, Krzyzanowski M, Studniarek M (2001) The usefulness of CBF brain SPECT in forensic medicine. A description of four cases. Nucl Med Rev 4:47–50Google Scholar
  10. Liberzon I, Taylor SF, Amdur R, Jung TD, Chamberlain KR, Minoshima S, Koeppe RA, Fig LM (1999) Brain activation in PTSD in response to trauma-related stimuli. Biol Psychiatry 45: 817–826PubMedCrossRefGoogle Scholar
  11. Mehr SH, Gerdes SL (2001) Medicolegal applications of PET scans. Neuro Rehab 16:87–92Google Scholar
  12. Monnett CG III, Jordan KM (2000) Scientific evidence following Daubert vs Merrill Dow. In: Charles G (ed) Are PET scans admissible to establish traumatic brain injury? (http://www.carolinalaw.com/html/pet_scans.html)
  13. Moran M (2003) Adolescent brain development argues against teen executions. Psychiatr News 38:10 (http://www.abanet.org/crimjust/juvjus.resources.html)Google Scholar
  14. Munoz-Céspedes JM, Paul-Lapedriza N (2001) La deteccion de los posibles casos de simulacion después de un traumatismo craneoencefalico. Rev Neurol 32:773–778PubMedGoogle Scholar
  15. Newport DJ, Nemeroff CB (2000) Neurobiology of posttraumatic stress disorder. Curr Opin Neurobiol 10:211–218PubMedCrossRefGoogle Scholar
  16. Paus T, Zijdenbos A, Worsley K, Collins DL, Blumenthal J, Giedd JN, Rapoport JL, Evans AC (1999) Structural maturation in children and adolescents, in vivo study. Science 283:1908–1911PubMedCrossRefGoogle Scholar
  17. Rauch SL, Van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jeniske MA, Pitman RK (1996) A symptom provocation study of posttraumatic stress disorder using PET and script driven imagery. Arch Gen Psychiatry 53:380–387PubMedCrossRefGoogle Scholar
  18. Rauch SL, Whalen PJ, Shin LM, McInerney SC, Macklin ML, Lasko NB, Orr SP, Pitman RK (2000) Exaggerated amygdala response to masked facial stimuli in posttraumatic stress disorder. Biol Psychiatry 47:769–776PubMedCrossRefGoogle Scholar
  19. Sapolksy RM, Uno H, Reberts CS, Finch CE (1990) Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci 10:2897–2902Google Scholar
  20. Society of Nuclear Medicine (1996) Ethical clinical practice of functional brain imaging. Report of Society of Nuclear Medicine Brain Imaging Council. J Nucl Med 37:1256–1259Google Scholar
  21. Sowell ER, Thompson PM, Tessner KD, Toga AW (2001) Mapping continued brain growth and grey matter density reduction in dorsal frontal cortex: inverse relationships during postadolescent brain maturation. J Neurosci 22:8819–8829Google Scholar
  22. Squire LR (1992) Memory and the hippocampus: a synthesis from findings with rats, monkeys and humans. Psychol Rev 99:195–231PubMedCrossRefGoogle Scholar
  23. Stein MB, Koverola C, Hanna C, Torchia MG, McClarty B (1997) Hippocampal volume in women victimised by childhood sexual abuse. Psychol Med 27:951–960CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Sukhi Shergill
    • 1
  • Kris H. Naudts
    • 2
  • J. Gunn
  1. 1.Division of Psychological Medicine, Section of Brain ImagingInstitute of PsychiatryLondonUK
  2. 2.Department of Psychiatry and Medical PsychologyUniversity Hospital GhentGentBelgium

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