Abstract
There is little research in the literature on functional neuro-imaging in apathy. However, the reported studies show that apathy is related to a decreased function of the anterior cingulate and connected fronto-subcortical structures. Research data and implications are presented in this chapter.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functional segregation circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357–381
Benoit M, Dygai I, Migneco O, Robert PH, Bertogliati C, Darcourt J et al (1999) Behavioral and psychological symptoms in Alzheimer’s disease. Dement Geriatr Cogn Dis 10:511–517
Benoit M, Koulibaly PM, Migneco O, Darcourt J, Pringuey DJ, Robert PH (2002) Brain perfusion in Alzheimers disease with and without apathy: a SPECT study with statistical parametric mapping analysis. Psychiatry Res Neuroimaging 114:103–111
Berrios GE, Gili M (1995) Abulia and impulsiveness revisited: a conceptual history. Acta Psychiatr Scand 92:161–167
Brown RG, Pluck G (2000) Negative symptoms: the pathology of motivation and goal-directed behavior. Trends Neurosci 23:412–417
Brunei H, Michel B, Pasquier J, Gastaut J (2003) Value of single photon emission computed tomography in the characterization of fronto-temporal dementia subtypes. J Neuroradiol 30: 37–45
Burns A, Jacoby R, Levy R (1990) Psychiatric phenomena in Alzheimers disease II: disorders of perception. Br J Psychiatry 157:76–81
Craig AH, Cummings JL, Fairbanks L, Itti L, Miller B, Li J et al (1996) Cerebral blood flow correlates of apathy in Alzheimer disease. Arch Neuro 53:1116–1120
Cummings JL, Mega MS, Gray K, Rosemberg-Thompson S, Gornbein T (1994) The neuropsychiatric inventory: comprehensive assessment of psychopathology in dementia. Neurology 44: 2308–2314
Cummings JL, Diaz C, Levy M (1996) Behavioral syndromes in neurodegenerative diseases: frequency and significance. Semin Neuropsychiatry 1:241–247
Cummings JL, Nadel A, Masterman D, Cyrus P (2001) Efficacy of metrifonate in improving the psychiatric and behavioral disturbances of patients with Alzheimers disease. J Geriatr Psychiatry Neurol 14:101–108
Engelborgsh S, Marien P, Pickut B, Verstraeten S, de Deyn P (2000) Loss of psychic self-activation after paramedian bithalamic infarction. Stroke 31:1762–1765
Kaufer D (1998) Beyond the cholinergic hypothesis: the effect of metrifonate and other cholinesterase inhibitors on neuropsychiatric symptoms in Alzheimers disease. Dement Geriatr Cogn Dis 9[Suppl 2]:8–14
Kuzis G, Sabe L, Tiberti C, Dorrego F, Starkstein SE (1999) Neuropsychological correlates of apathy and depression in patients with dementia. Neurology 52:1403–1407
Levy ML, Cummings JL, Fairbanks LA, Masterman D, Miller BL, Craig AH, et al. (1998) Apathy is not depression. J Neuropsy Clin N 10:314–319
Marin RS (1996) Apathy: concept, syndrome, neural mechanisms and treatment. Semin Clin Neuropsychiatry 1:304–314
Marin RS, Biedrzycki RC, Firinciogullari S (1991) Reliability and validity of the apathy evaluation scale. Psychiatry Res 38:143–162
Mesulam MM, Geula C (1988) Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain. J Comp Neurol 275:216–240
Mesulam MM, Mufson EJ, Levey AI, Wainer BH (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis and hypothalamus in the rhesus monkey. J Comp Neurol 214:170–197
Migneco O, Benoit M, Koulibaly PM, Dygai I, Bertogliati C, Desvignes P, Robert PH, Malandain G, Bussiere F, Darcourt J (2001) Perfusion brain SPECT and statistical parametric mapping analysis indicate that apathy is a cingulate syndrome: a study in Alzheimers disease and non-demented patients. Neuroimage 13:896–902
Nordberg A (1994) Use of PET technique to monitor effect of drugs in Alzheimer disease treatment. In: Giacobini E, Becker R (eds) Alzheimer disease: therapeutic strategies. Birkhauser, Boston, pp 405–412
Robert PH, Clairet S, Benoit M, Koutaich J, Bertogliati C, Tible O et al (2002) The Apathy Inventory: assessment of apathy and awareness in Alzheimers disease, Parkinsons disease and mild cognitive impairment. Int J Geriatr Psychiatry 17:1099–1105
Robert PH, Migneco O, Koulibaly M, Bertogliati C, Dygai C, Benoit M et al (2001) Cingulate and attentional correlates of apathy in Alzheimers disease. Brain Cogn 47:300–303
Starkstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG (1992) Reliability, validity and clinical correlates of apathy in Parkinsons disease. J Neuropsychiatry Clin Neurosci 4:134–139
Starkstein SE, Petracca G, Chemerinski E, Kremer J (2001) Syndromic validity of apathy in Alzheimers disease. Am J Psychiatry 158:872–877
Stuss DT, Van Reekum R, Murphy KJ (2000) Differentiation of states and causes of apathy. Oxford University Press, New York
Van der Werf Y, Weerts J, Jolles J, Witter M, Lindeboom J, Scheltens P (1999) Neuropsychological correlates of a right unilateral lacunar thalamic infarction. J Neurol Neurosurg Psychiatry 66:36–42
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Migneco, O., Koulibaly, P.M., Benoit, M., Darcourt, J., Robert, P. (2004). Functional Neuro-imaging in Apathy. In: Otte, A., Audenaert, K., Peremans, K., van Heeringen, K., Dierckx, R.A. (eds) Nuclear Medicine in Psychiatry. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18773-5_32
Download citation
DOI: https://doi.org/10.1007/978-3-642-18773-5_32
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-62287-8
Online ISBN: 978-3-642-18773-5
eBook Packages: Springer Book Archive