Perfusion Tracers: Biological Bases and Clinical Implications
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Several radiopharmaceuticals are used in the clinical setting for brain imaging by the nuclear medicine modalities PET and SPECT. Among them, HMPAO and ECD are the most widely used, and it is usually assumed that they both reflect regional cerebral perfusion. Study of the biological basis of their cellular mechanisms at the basis of their brain retention highlighted that besides reflecting local flow, regional metabolic patterns may lead to the uncoupling perfusion signal with local retention of the tracer. Furthermore, it appears that very interesting similarities are emerging between astrocytes-neurons deoxyglucose/energy exchange and HMPAO/oxido-reduction equilibrium in normal state as well as in pathophysiological conditions.
KeywordsPositron Emission Tomography Single Photon Emission Compute Tomography Regional Cerebral Blood Flow Cereb Blood Flow Perfusion Tracer
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