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Nuclear Brain Imaging in Mood Disorders

  • Dirk Van den Abbeele
  • Kurt Audenaert
  • Kathelijne Peremans
  • Andreas Otte
  • Rudi Dierckx
  • Kees Van Heeringen
Chapter
  • 126 Downloads

Abstract

Mood disorders are amongst the most prevalent disorders in our society and have an important socio-economic impact. Nowadays, there is consensus on a psycho-biosocial model that hosts vulnerability factors as well as protective factors in the pathogenesis of mood disorders. Unfortunately, despite extensive biological research in general and brain imaging in particular, the results have been far from unanimous. Both methodological issues and diagnosis-related factors seem to be at least responsible for these unequivocal results. In this book chapter a brief overview on brain perfusion and metabolism studies in patients with depression is given. Most unanimity is found on functional changes in the prefrontal cortex. Therefore, in a separate table, brain perfusion and metabolism studies in depression, reporting on prefrontal brain are summarized. Additionally, other brain regions will be overviewed. Furthermore, the authors evaluate studies that report on the impact of medication, electroconvulsive therapy (ECT) and on repetitive transcranial magnetic Stimulation (rTMS).

Keywords

Prefrontal Cortex Transcranial Magnetic Stimulation Depressed Patient Mood Disorder Vagus Nerve Stimulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abercrombie HC, Schaefer SM, Larson CL, Oakes TR, Lindgren KA, Holden JE, Perlman SB, Turski PA, Krahn DD, Benca RM, Davidson RJ (1998) Metabolie rate in the right amygdala predicts negative affect in depressed patients. Neuroreport 9:3301–3307PubMedCrossRefGoogle Scholar
  2. Abou-Saleh MT, AI Suhaili AR, Karim L, Prais V, Hamdi E (1999) Single photon emission tomography with 99m Tc-HMPAO in Arab patients with depression. J Affect Disord 55:115–123PubMedCrossRefGoogle Scholar
  3. Al-Mousawi AH, Evans N, Ebmeier KP, Roeda D, Chaloner F, Ashcroft GW (1996) Limbic dysfunetion in schizophrenia and mania — a study using F-18-labelled fluorodeoxyglucose and positron emission tomography. Br J Psychiatry 169:509–516PubMedCrossRefGoogle Scholar
  4. American Psychiatric Association (2000) DSM-IV-TR: diagnostic and Statistical manual of mental disorders. American Psychiatric Association, PhiladelphiaGoogle Scholar
  5. Austin MP, Dougall N, Ross M, Murray C, Ocarroll RE, Moffoot A, Ebmeier KP, Goodwin GM (1992) Single photon-emission tomography with TC-99m-exametazime in major depression and the pattern of brain activity underlying the psychotic neurotic continuum. J Affect Dis?ord 26:31–43CrossRefGoogle Scholar
  6. Awata S, Ito H, Konno M, Ono S, Kawashima R, Fukuda H, Sato M (1998) Regional cerebral blood flow abnormalities in late-life depression: relation to refractoriness and chronification. Psychiatry Clin Neurosci 52:97–105PubMedCrossRefGoogle Scholar
  7. Awata S, Konno M, Kawashima R, Suzuki K, Sato T, Matsuoka H, Fukuda H, Sato M (2002) Regional cerebral blood flow abnormalities in late-life depression following response to electro-convulsive therapy. Psychiatry Clin Neurosci 1:31–40CrossRefGoogle Scholar
  8. Barch DM, Sheline YI, Csernansky JG, Snyder AZ (2003) Working memory and prefrontal cortex dysfunetion: speeificity to schizophrenia compared with major depression. Biol Psychiatry 53:376–384PubMedCrossRefGoogle Scholar
  9. Barker AT, Jalinous R (1985) Non-invasive magnetic Stimulation of human motor cortex. Lancet 1:1106–1107PubMedCrossRefGoogle Scholar
  10. Baxter LR, Phelps ME, Mazziotta JC, Schwartz JM, Gerner RH, Selin CE, Sumida RM (1985) Cerebral metabolic rates for glucose in mood disorders. Arch Gen Psychiatry 42:441–447PubMedCrossRefGoogle Scholar
  11. Baxter LR, Schwartz JM, Phelps ME, Mazziotta JC, Guze BH, Selin CE, Gerner RH, Sumida RM (1989) Reduction of prefrontal cortex glucose-metabolism common to 3 types of depression. Arch Gen Psychiatry 46:243–250PubMedCrossRefGoogle Scholar
  12. Bench CJ, Friston KJ, Brown RG, Scott LC, Frackowiak RSJ, Dolan RJ (1992) The anatomy of melancholia — focal abnormalities of cerebral blood-flow in major depression. Psychol Med 22: 607–615PubMedCrossRefGoogle Scholar
  13. Bench CJ, Frackowiak RSJ, Dolan RJ (1995) Changes in regional cerebral blood-flow on recovery from depression. Psychol Med 25:247–261PubMedCrossRefGoogle Scholar
  14. Berman KF, Doran AR, Pickar d, Weinberger DR (1993) Is the mechanism of prefrontal hypo-function in depression the same as in schizophrenia — regional cerebral blood-flow during cognitive activation. Br J Psychiatry 162:183–192PubMedCrossRefGoogle Scholar
  15. Biver F, Goldman S, Delvenne V, Luxen A, Demaertelaer V, Hubain P, Mendlewicz J, Lotstra F (1994) Frontal and parietal metabolic disturbances in unipolar depression. Biol Psychiatry 36:381–388PubMedCrossRefGoogle Scholar
  16. Bonne O, Krausz Y, Gorfine M, Karger H, Gelfin Y, Shapira B, Chisin R, Lerer G (1996a) Cerebral hypoperfusion in medication resistant, depressed patients assessed by Tc99m HMPAO SPECT. J Affect Disord 41:163–171PubMedCrossRefGoogle Scholar
  17. Bonne O, Krausz Y, Shapira B, Bocher M, Karger H, Gorfine M, Chisin R, Lerer B (1996b) Increased cerebral blood flow in depressed patients responding to electroconvulsive therapy. J Nucl Med 37:1075–1080PubMedGoogle Scholar
  18. Bonne O, Louzoun Y, Aharon I, Krausz Y, Karger H, Lerer B, Bocher M, Freedman N, Chisin R (2003) Cerebral blood flow in depressed patients: a methodological comparison of Statistical parametric mapping and region of interest analyses. Psychiatry Res Neuroimaging 122: 49–57CrossRefGoogle Scholar
  19. Buchsbaum MS, Cappelletti J, Ball R, Hazlett E, King AC, Johnson J, Wu J, Delisi LE (1984) Positron emission tomographic image measurement in schizophrenia and affective disorders. Ann Neuroll 15:S157–S165CrossRefGoogle Scholar
  20. Buchsbaum MS, Wu J, Delisi LE, Holcomb H, Kessler R, Johnson J, King AC, HazletT E, Längsten K, Post RM (1986) Frontal-cortex and basal ganglia metabolic rates assessed by positron emission tomography with [F-18] 2-deoxyglucose in affective-illness. J Affect Disord 10: 137–152PubMedCrossRefGoogle Scholar
  21. Buchsbaum MS, Wu J, Siegel BV, Hackett E, Trenary M, Abel L, Reynolds C (1997) Effect of sertra-line on regional metabolic rate in patients with affective disorder. Biol Psychiatry 41:15–22CrossRefGoogle Scholar
  22. Catafau AM, Perez V, Gironeil A, Martin JC, Kulisevsky J, Estorch M, Carrio I, Alvarez E (2001) SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic Stimulation in depressed patients. A pilot study. Psychiatry Res Neuroimaging 106:151–160CrossRefGoogle Scholar
  23. Chen R, Classen J, Gerloff C, Celnik P, Wassermann EM, Halle? M, Cohen LG (1997) Depression of motor cortex excitability by low-frequency transcranial magnetic Stimulation. Neurology 48:1398–1403CrossRefGoogle Scholar
  24. Coffey CE, Wilkinson WE, Weiner RD, Parashos IA, Djang WT, Webb MC, Figiel GS, Spritzer CE (1993) Quantitative cerebral anatomy in depression — a controlled magnetic-resonance-imaging study. Arch Gen Psychiatry 50:7–16PubMedCrossRefGoogle Scholar
  25. Cohen RM, Semple WE, Gross M, Nordahl TE, King AC, Pickar D, Post RM (1989) Evidence for common alterations in cerebral glucose-metabolism in major affective disorders and schizophrenia. Neuropsychopharmacology 2:241–254PubMedCrossRefGoogle Scholar
  26. Curran SM, Murray CM, Vanbeck M, Dougall N, Ocarroll RE, Austin MP, Ebmeier KP, Goodwin GM (1993) A single-photon emission Computerized-tomography study of regional brain function in elderly patients with major depression and with Alzheimer-type dementia. Br J Psychiatry 163:155–165PubMedCrossRefGoogle Scholar
  27. De Asis JM, Stern E, Alexopoulos GS, Pan H, Van Gorp W, Blumberg H, Kalayam B, Eideiberg D, Kiosses D, Silbersweig DA (2001) Hippocampal and anterior cingulate activation deficits in patients with geriatric depression. Am J Psychiatry 158:1321–1323PubMedCrossRefGoogle Scholar
  28. DelBello MP, Strakowski SM, Zimmerman ME, Hawkins JM, Sax KW (1999) MRI analysis of the cerebellum in bipolar disorder: a pilot study Neuropsychopharmacology 21:63–68PubMedCrossRefGoogle Scholar
  29. Drevets WC (1999) Prefrontal cortical-amygdalar metabolism in major depression. Advancing from the ventral striatum to the extended amygdala. Ann N Y Acad Sei 877:614–637CrossRefGoogle Scholar
  30. Drevets WC (2000) Neuroimaging studies of mood disorders. Biol Psychiatry 48:813–829PubMedCrossRefGoogle Scholar
  31. Drevets WC, Videen TO, Price JL, Preskorn SH, Carmichael ST, Raichle ME (1992) A functional anatomical study of unipolar depression. J Neurosci 12:3628–3641PubMedGoogle Scholar
  32. Drevets WC, Price JL, Simpson JR, Todd RD, Reich T, Vannier M, Raichle ME (1997) Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386:824–827CrossRefGoogle Scholar
  33. Drevets WC, Bogers W, Raichle ME (2002) Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism. Eur Neuropsy-chopharmacol 12:527–544CrossRefGoogle Scholar
  34. Ebert D, Feistel H, Barocka A, Kaschka W (1994) Increased limbic blood-flow and total sleep-deprivation in major depression with melancholia. Psychiatry Res Neuroimaging 55:101–109CrossRefGoogle Scholar
  35. Elger G, Hoppe C, Falkai P, Rush AJ, Elger CE (2000) Vagus nerve Stimulation is associated with mood improvements in epilepsy patients. Epilepsy Res 42:203–210PubMedCrossRefGoogle Scholar
  36. Galynker I, Cai J, Dutta E, Serseni D, Miner C, Ongseng F, Gallagher R (1996) Hypofrontality in major depressive disorder: relationship to Psychiatric Symptoms. Biol Psychiatry 39:350Google Scholar
  37. Galynker II, Cai J, Ongseng F, Finestone H, Dutta E, Serseni D (1998) Hypofrontality and negative Symptoms in major depressive disorder. J Nucl Med 39:608–612PubMedGoogle Scholar
  38. George MS, Ketter TA, Parekh PI, Horwitz B, Herscovitch P, Post RM (1995) Brain activity during transient sadness and happiness in healthy women. Am J Psychiatry 152:341–351PubMedGoogle Scholar
  39. George MS, Sackeim HA, Rush AJ, Marangell LB, Nahas Z, Husain MM, Lisanby S, Burt T, Goldman J, Ballenger JC (2000) Vagus nerve Stimulation: a new tool for brain research and thera-py. Biol Psychiatry 47:287–295PubMedCrossRefGoogle Scholar
  40. Hagman JO, Buchsbaum MS, Wu JC, Rao SJ, Reynolds CA, Blinder BJ (1990) Comparison of regional brain metabolism in bulimia-nervosa and affective-disorder assessed with positron emission tomography. J Affect Disord 19:153–162PubMedCrossRefGoogle Scholar
  41. Henry TR, Bakay RAE, Votaw JR, Penneil PB, Epstein CM, Faber TL, Grafton ST, Hoffman JM (1998) Brain blood flow alterations induced by therapeutic vagus nerve Stimulation in partial epilepsy. I. Acute effects at high and low levels of Stimulation. Epilepsia 39:983–990PubMedCrossRefGoogle Scholar
  42. Henry TR, Votaw JR, Pennell PB, Epstein CM, Bakay RAE, Faber TL, Grafton ST, Hoffman JM (1999) Acute blood flow changes and efficacy of vagus nerve Stimulation in partial epilepsy. Neurology 52:1166–1173PubMedCrossRefGoogle Scholar
  43. Ho AP, Gillin JC, Buchsbaum MS, Wu JC, Abel L, Bunney WE (1996) Brain glucose metabolism during non-rapid eye movement sleep in major depression — a positron emission tomography study. Arch Gen Psychiatry 53:645–652PubMedCrossRefGoogle Scholar
  44. Hornig M, Mozley PD, Amsterdam JD (1997) HMPAO SPECT brain imaging in treatment-resist-ant depression. Prog Neuropsychopharmacol Biol Psychiatry 21:1097–1114CrossRefGoogle Scholar
  45. Hurwitz TA, Clark C, Murphy E, Klonoff H, Martin WRW, Pate BD (1990) Regional cerebral glu-cose-metabolism in major depressive disorder. Can J Psychiatry Rev Can Psychiatrie 35:684–688Google Scholar
  46. Ito H, Kawashima R, Awata S, One S, Sato K, Goto R, Koyama M, Sato M, Fukuda H (1996) Hypoperfusion in the limbic System and prefrontal cortex in depression: SPECT with anatomic standardization technique. J Nucl Med 37:410–414PubMedGoogle Scholar
  47. Ketter TA, Kimbrell TA, George MS, Dünn RT, Speer AM, Benson BE, Willis MW, Danielson A, Frye MA, Herscovitch P, Post RM (2001) Effects of mood and subtype on cerebral glucose metabolism in treatment-resistant bipolar disorder. Biol Psychiatry 49:97–109PubMedCrossRefGoogle Scholar
  48. Kimbrell TA, Little JT, Dünn RT, Frye MA, Greenberg BD, Wassermann EM, Repella JD, Danielson AL, Willis MW, Benson BE, Speer AM, Osuch E, George MS, Post RM (1999) Frequen-cy dependence of antidepressant response to left prefrontal repetitive transcranial magnetic Stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol Psychia?try 46:1603–1613CrossRefGoogle Scholar
  49. Klein E, Kreinin I, Christyakov A, Koren D, Mecz L, Marmur S, Ben Shachar D, Feinsod M (1999) Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic Stimulation in major depression — a double blind controlled study. Arch Gen Psychiatry 4:315–320CrossRefGoogle Scholar
  50. Kling AS, Metter EJ, Riege WH, Kühl DE (1986) Comparison of pet measurement of local brain glucose metabolism and cat measurement of brain atrophy in chronic schizophrenia and depression. Am J Psychiatry 143:175–180PubMedGoogle Scholar
  51. Ko D, Heck C, Grafton S, Apuzzo MLJ, Couldwell WT, Chen T, Day JD, Zelman V, Smith T, DeGiorgio CM (1996) Vagus nerve Stimulation activates central nervous System structures in epileptic patients during PET (H20)-0-15 blood flow imaging. Neurosurgery 39:426–430PubMedCrossRefGoogle Scholar
  52. Kocmur M, Milcinski M, Budihna NV (1998) Evaluation of brain perfusion with technetium-99m bicisate single-photon emission tomography in patients with depressive disorder before and after drug treatment. Eur J Nucl Med 25:1412–1414PubMedCrossRefGoogle Scholar
  53. Krishnan KRR (1993) Neuroanatomical Substrates of depression in the elderly. J Geriatr PsychiatryNeurol 6:39–58Google Scholar
  54. Kumar A, Newberg A, Alavi A, Berlin J, Smith R, Reivich M (1993) Regional cerebral glucose metabolism in late-life depression and Alzheimer disease — a preliminary positron emission tomography study. Proc Natl Acad Sei U S A 90:7019–7023CrossRefGoogle Scholar
  55. Lesser IM, Mena I, Boone KB, Miller BL, Mehringer CM, Wohl M (1994) Reduction of cerebral blood-flow in older depressed-patients. Arch Gen Psychiatry 51:677–686PubMedCrossRefGoogle Scholar
  56. Maes M, Dierckx R, Meltzer HY, Ingels M, Schotte C, Vandewoude M, Calabrese J, Cosyns P (1993) Regional cerebral blood-flow in unipolar depression measured with tc-99m-hmpao single-photon emission computed-tomography — negative findings. Psychiatry Res Neuroimaging 50:77–88CrossRefGoogle Scholar
  57. Martinot JL, Hardy P, Feline A, Huret JD, Mazoyer B, Attarlevy D, Pappata S, Syrota A (1990) Left prefrontal glucose hypometabolism in the depressed State — a confirmation. Am J Psychiatry 147:1313–1317PubMedGoogle Scholar
  58. Mayberg HS (2003) Modulating dysfunctional limbic-cortical cireuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment. Br Med Bull 65: 193–207PubMedCrossRefGoogle Scholar
  59. Mayberg HS, Lewis PJ, Regenold W, Wagner HN (1994) Paralimbic hypoperfusion in unipolar depression. J Nucl Med 35:929–934PubMedGoogle Scholar
  60. Mayberg HS, Brannan SK, Mahurin RK, Jerabek PA, Brickman JS, Tekell JL, Silva JA, McGinnis S, Glass TG, Martin CC, Fox PT (1997) Cingulate funetion in depression: a potential predictor of treatment response. Neuroreport 8:1057–1061CrossRefGoogle Scholar
  61. Mayberg HS, Liotti M, Brannan SK, McGinnis S, Mahurin RK, Jerabek PA, Silva JA, Tekell JL, Martin CC, Lancaster JL, Fox PT (1999) Reciprocal limbic-cortical funetion and negative mood: converging PET findings in depression and normal sadness. Am J Psychiatry 156:675–682PubMedGoogle Scholar
  62. Mayberg HS, Brannan SK, Tekell JL, Silva JA, Mahurin RK, McGinnis S, Jerabek PA (2000) Regional metabolic effects of fluoxetine in major depression: serial changes and relationship to clinical response. Biol Psychiatry 48:830–843PubMedCrossRefGoogle Scholar
  63. Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, Jerabek PA (2002) The functional neuroanatomy of the placebo effect. Am J Psychiatry 159:728–737PubMedCrossRefGoogle Scholar
  64. Mega MS, Cummings JL (1994) Frontal-subcortical cireuits and neuropsychiatric disorders. J Neuropsychiatry Clin Neurosci 6:358–370PubMedGoogle Scholar
  65. Milo TJ, Kaufman GE, Barnes WE, Konopka LM, Crayton JW, Ringelstein JG, Shirazi PH (2001) Changes in regional cerebral blood flow after electroconvulsive therapy for depression. J Ect 17:15–21PubMedCrossRefGoogle Scholar
  66. Mottaghy FM, Keller CE, Gangitano M, Ly J, Thall M, Parker JA, Pascual-Leone A (2002) Correla-tion of cerebral blood flow and treatment effects of repetitive transcranial magnetic Stimulation in depressed patients. Psychiatry Res Neuroimaging 115:1–14CrossRefGoogle Scholar
  67. Mozley PD, HornigRohan M, Woda AM, Kim HJ, ALAVI A, Payer F, Amsterdam JD (1996) Cerebral HMPAO SPECT in patients with major depression and healthy volunteers. Prog Neuropsychopharmacol Biol Psychiatry 20:443–458PubMedCrossRefGoogle Scholar
  68. Nadeau SE, McCoy KJM, Crucian GP, Greer RA, Rossi F, Bowers D, Goodman WK, Heilman KM, Triggs WJ (2002) Cerebral blood flow changes in depressed patients after treatment with repetitive transcranial magnetic Stimulation: evidence of individual variability. Neuropsychia?try Neuropsychol Behav Neurol 15:159–175Google Scholar
  69. Navarro V, Gasto C, Lomena F, Mateos JJ, Marcos T (2001) Frontal cerebral perfusion dysfunction in elderly late-onset major depression assessed by (TC)-T-99M-HMPAO SPECT. Neu-roimage 14:202–205Google Scholar
  70. Navarro V, Gasto C, Lomena F, Mateos JJ, Marcos T, Portella MJ (2002) Normalization of frontal cerebral perfusion in remitted elderly major depression: a 12-month follow-up SPECT study. Neuroimage 16:781–787PubMedCrossRefGoogle Scholar
  71. Nobler MS, Oquendo MA, Kegeies LS, Malone KM, Campbell C, Sackeim HA, Mann JJ (2001) De-creased regional brain metabolism after ECT. Am J Psychiatry 158:305–308PubMedCrossRefGoogle Scholar
  72. Oda K, Okubo Y, Ishida R, Murata Y, Ohta K, Matsuda T, Matsushima E, Ichimiya T, Suhara T, Shibuya H, Nishikawa T (2003) Regional cerebral blood flow in depressed patients with white matter magnetic resonance hyperintensity. Biol Psychiatry 53:150–156PubMedCrossRefGoogle Scholar
  73. Ogura A, Morinobu S, Kawakatsu S, Totsuka S, Komatani A (1998) Changes in regional brain activity in major depression after successful treatment with antidepressant drugs. Acta Psychiatr Scand 98:54–59PubMedCrossRefGoogle Scholar
  74. Pascual-Leone A, Vallssole J, Wassermann EM, Hallett M (1994) Responses to rapid-rate transcranial magnetic Stimulation of the human motor cortex. Brain 117:847–858PubMedCrossRefGoogle Scholar
  75. Pascual-Leone A, Rubio B, Pallardo F, Catala MD (1996) Rapid-rate transcranial magnetic Stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 348:233–237PubMedCrossRefGoogle Scholar
  76. Peschina W, Conca A, Konig P, Fritzsche H, Beraus N (2001) Low-frequency rTMS as an add-on antidepressive strategy: heterogeneous impact on Tc-99m-HMPAO and F-18-FDG uptake as measured simultaneously with the double isotope SPECT technique. Pilot study. Nucl Med Commun 22:867–873CrossRefGoogle Scholar
  77. Post RM, Delisi LE, Holcomb HH, Uhde TW, Cohen R, Buchsbaum MS(1987) Glucose-utilization in the temporal cortex of affectively ill patients — positron emission tomography. Biol Psychiatry 22:545–553PubMedCrossRefGoogle Scholar
  78. Rajkowska G (2000) Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psychiatry 48:766–777PubMedCrossRefGoogle Scholar
  79. Rajkowska G (2002) Cell pathology in bipolar disorder. Bipolar Disord 4:105–116PubMedCrossRefGoogle Scholar
  80. Reiman EM, Lane RD, Ahern GL, Schwartz GE, Davidson RJ, Friston KJ, Yun LS, Chen KW (1997) Neuroanatomical correlates of externally and internally generated human emotion. Am J Psychiatry 154:918–925Google Scholar
  81. Rubin E, Sackeim HA, Prohovnik I, Moeller JR, Schnur DB, Mukherjee S (1995) Regional cerebral blood-flow in mood disorders — comparison of mania and depression. Psychiatry Res Neuroimaging 61:1–10CrossRefGoogle Scholar
  82. Sackeim HA, Prohovnik I, Moeller JR, Brown RP, Apter S, Prudic J, Devanand DP, Mukherjee S (1990) Regional cerebral blood-flow in mood disorders — comparison of major depressives and normal controls at rest. Arch Gen Psychiatry 47:60–70PubMedCrossRefGoogle Scholar
  83. Schlegel S, Aldenhoff JB, Eissner D, Lindner P, Nickel O (1989) Regional cerebral blood-flow in depression — associations with psychopathology. J Affect Disord 17:211–218PubMedCrossRefGoogle Scholar
  84. Schneider F, Gur RC, Jaggi JL, Gur RE (1994) Differential effects of mood on cortical cerebral blood-flow — a XE-133 clearance study. Psychiatry Res 52:215–236PubMedCrossRefGoogle Scholar
  85. Shah SA, Doraiswamy PM, Husain MM, Escalona PR, Na C, Figiel GS, Patterson LJ, Ellinwood EH, McDonald WM, Boyko OB, Nemeroff CB, Krishnan KRR (1992) Posterior-fossa abnor-malities in major depression — a controlled magnetic-resonance-imaging study. Acta Psychiatr Scand 85:474–479PubMedCrossRefGoogle Scholar
  86. Sheline YI (2000) 3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity. Biol Psychiatry 48:791–800PubMedCrossRefGoogle Scholar
  87. Soares JC, Mann JJ (1997) The functional neuroanatomy of mood disorders. J Psychiatr Res 31: 393–432CrossRefGoogle Scholar
  88. Speer AM, Kimbrell TA, Wassermann EM, Repella JD, Willis MW, Herscovitch P, Post RM (2000) Opposite effects of high-and low-frequency rTMS on regional brain activity in depressed pa?tients. Biol Psychiatry 48:1133–1141PubMedCrossRefGoogle Scholar
  89. Strakowski SM, DelBello MP, Adler C, Cecil KM, Sax KW (2000) Neuroimaging in bipolar disorder. Bipolar Disord 2:148–164PubMedCrossRefGoogle Scholar
  90. Tekin S, Cummings JL (2002) Frontal-subcortical neuronal circuits and clinical neuropsychiatry — an update. J Psychosom Res 53:647–654PubMedCrossRefGoogle Scholar
  91. Teneback CC, Nahas Z, Speer AM, Molloy M, Stallings LE, Spicer KM, Risch SC, George MS (1999) Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J Neuropsychiatry Clin Neurosci 11:426–435PubMedGoogle Scholar
  92. Tutus A, Simsek A, Sofuoglu S, Nardali M, Kugu N, Karaaslan F, Gonul AS (1998) Changes in regional cerebral blood flow demonstrated by Single photon emission computed tomography in depressive disorders: comparison of unipolar vs bipolar Subtypes. Psychiatry Res Neuroimaging 83:169–177CrossRefGoogle Scholar
  93. Van Laere K, Vonck K, Boon P, Brans B, Vandekerckhove T, Dierckx R (2000) Vagus nerve Stimu?lation in refractory epilepsy: SPECT activation study. J Nucl Med 41:1145–1154PubMedGoogle Scholar
  94. Vasile RG, Schwartz RB, Garada B, Holman BL, Alpert M, Davidson PB, Schildkraut JJ (1996) Fo-cal cerebral perfusion defects demonstrated by Tc-99m-hexamethylpropyleneamine oxime SPECT in elderly depressed patients. Psychiatry Res Neuroimaging 67:59–70CrossRefGoogle Scholar
  95. Videbech P, Ravnkilde B, Pedersen AR, Egander A, Landbo B, Rasmussen NA, Andersen F, Stod-kilde-Jorgensen H, Gjedde A, Rosenberg R (2001) The Danish PET/depression project: PET findings in patients with major depression. Psychol Med 31:1147–1158PubMedCrossRefGoogle Scholar
  96. Videbech P, Ravnkilde B, Pedersen TH, Hartvig H, Egander A, Clemmensen K, Rasmussen NA, Andersen F, Gjedde A, Rosenberg R (2002) The Danish PET/depression project: clinical Symptoms and cerebral blood flow. A regions-of-interest analysis. Acta Psychiatr Scand 106:35–44PubMedCrossRefGoogle Scholar
  97. Yazici KM, Kapucu O, Erbas B, Varoglu E, Gulec C, Bekdik CF (1992) Assessment of changes in regional cerebral blood-flow in patients with major depression using the tc-99m-hmpao Single photon-emission tomography method. Eur J Nucl Med 19:1038–1043PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Dirk Van den Abbeele
    • 1
  • Kurt Audenaert
    • 1
  • Kathelijne Peremans
    • 2
  • Andreas Otte
    • 3
  • Rudi Dierckx
    • 3
  • Kees Van Heeringen
    • 1
  1. 1.Department of Psychiatry and Medical PsychologyUniversity Hospital GhentGentBelgium
  2. 2.Department of Medical ImagingFaculty of Veterinary MedicineMerelbekeBelgium
  3. 3.Division of Nuclear MedicineUniversity Hospital GhentGentBelgium

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