Nuclear Brain Imaging in Mood Disorders

  • Dirk Van den Abbeele
  • Kurt Audenaert
  • Kathelijne Peremans
  • Andreas Otte
  • Rudi Dierckx
  • Kees Van Heeringen


Mood disorders are amongst the most prevalent disorders in our society and have an important socio-economic impact. Nowadays, there is consensus on a psycho-biosocial model that hosts vulnerability factors as well as protective factors in the pathogenesis of mood disorders. Unfortunately, despite extensive biological research in general and brain imaging in particular, the results have been far from unanimous. Both methodological issues and diagnosis-related factors seem to be at least responsible for these unequivocal results. In this book chapter a brief overview on brain perfusion and metabolism studies in patients with depression is given. Most unanimity is found on functional changes in the prefrontal cortex. Therefore, in a separate table, brain perfusion and metabolism studies in depression, reporting on prefrontal brain are summarized. Additionally, other brain regions will be overviewed. Furthermore, the authors evaluate studies that report on the impact of medication, electroconvulsive therapy (ECT) and on repetitive transcranial magnetic Stimulation (rTMS).


Prefrontal Cortex Transcranial Magnetic Stimulation Depressed Patient Mood Disorder Vagus Nerve Stimulation 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Dirk Van den Abbeele
    • 1
  • Kurt Audenaert
    • 1
  • Kathelijne Peremans
    • 2
  • Andreas Otte
    • 3
  • Rudi Dierckx
    • 3
  • Kees Van Heeringen
    • 1
  1. 1.Department of Psychiatry and Medical PsychologyUniversity Hospital GhentGentBelgium
  2. 2.Department of Medical ImagingFaculty of Veterinary MedicineMerelbekeBelgium
  3. 3.Division of Nuclear MedicineUniversity Hospital GhentGentBelgium

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