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Functional Brain Imaging in the Dog: Perfusion and Serotonin-2A Receptor Imaging in Physiological and Pathophysiological Conditions

  • Kathelijne Peremans
  • Kurt Audenaert
  • Andreas Otte
  • H. van Bree
  • Kees van Heeringen
  • Rudi Dierckx
Chapter
  • 123 Downloads

Abstract

The development of a canine model for research on both brain physiology and pathophysiology is expounded in this chapter. The results of investigations on brain perfusion and binding index of the specific serotonin-2A radioligand, 123I-5-I-R91150, in normal young dogs (younger than 8 years) and in nondemented old dogs (older than 8 years) are depicted. Concerning pathophysiology, perfusion and serotonin-2A receptor radioligand binding are examined in a group of aggressive, impulsive dogs and compared with a group of dogs without this behaviour. In the last part of this chapter, the influence of pharmacological intervention with selective serotonin re-uptake inhibitors (SSRIs) on measures of perfusion and serotonin-2A radioligand binding in impulsive aggressive dogs is demonstrated.

Keywords

Brain Perfusion Perfusion Index Transmission Compute Tomographic Partial Volume Effect Binding Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Kathelijne Peremans
    • 1
  • Kurt Audenaert
    • 2
  • Andreas Otte
    • 3
  • H. van Bree
    • 4
  • Kees van Heeringen
    • 2
  • Rudi Dierckx
    • 3
  1. 1.Department of Medical ImagingFaculty of Veterinary MedicineMerelbekeBelgium
  2. 2.Department of Psychiatry and Medical PsychologyUniversity Hospital GhentGentBelgium
  3. 3.Division of Nuclear MedicineUniversity Hospital GhentGentBelgium
  4. 4.Department of Medical Imaging, Faculty of Veterinary MedicineGhent UniversityMerelbekeBelgium

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