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Functional Imaging and Functional Psychopathology: An Introductory Chapter

  • Kurt Audenaert
  • Andreas Otte
  • Kathelijne Peremans
  • C. van Heeringen
  • Rudi Dierckx
Chapter
  • 127 Downloads

Abstract

During the first decades of the twentieth century, the work of Freud was founding the basis for our insights on the processes of mental life. But most important of all, as is stated by Kandel, the Nobel medicine laureate in 2000, it offered us concepts to understand the irrationality of human motivation (Kandel 1999). Indeed, Freud’s work still represents the most exciting and intellectually satisfying view of the mind. In his early writings, Freud, already in 1920, argued that biology was not advanced enough to be helpful to psychoanalysis at that time and that it was premature to bring the two together. However, he expected physiology and chemistry “to be of a kind that will blow away the whole of our artificial structure of hypothesis” (Freud 1975; Kandel 1999).

Keywords

Anorexia Nervosa Eating Disorder Hamilton Depression Rate Scale Serotonergic System Nuclear Medicine Physician 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Angst J, Dobler-Mikkola A (1985) The Zurich study VI. A continuum for depression and anxiety disorders? Eur Arch Psychiatry Neurol Sci 235:179–186PubMedCrossRefGoogle Scholar
  2. Attar-Lévy D, Martinot J, Blin J, Dao-Castellana M, Crouzel C, Mazoyer B, Poirier M, Bourdel M, Aymard N, Syrota A, Féline A (1999) The cortical serotonin-2 receptors studied with positron-emission tomography and 18F-setoperone during depressive illness and antidepressant treatment with clomipramine. Biol Psychiatry 45:180–186PubMedCrossRefGoogle Scholar
  3. Audenaert K, Van Laere K, Dumont F, Slegers G, Van Heeringen C, Dierckx R (2001) Decreased frontal serotonin 5-HT2a receptor binding potential in deliberate self harm. Eur J Nucl Med 28:175–182PubMedCrossRefGoogle Scholar
  4. Audenaert K, Van Laere K, Dumont F, Vervaet M, Goethals I, Slegers G, Mertens J, Van Heeringen C, Dierckx R (2003) Decreased 5-HT2a receptor binding in patients with anorexia nervosa. J Nucl Med 44:163–169PubMedGoogle Scholar
  5. Bernagie K, Jacobs F, Audenaert K, Slegers G, Mertens J, Dierckx R, Van Heeringen C (2003) Imaging cerebral serotonin 2A receptors in impulsive aggressive patients. Eur J Nucl Med Mol Imag 30:S 302Google Scholar
  6. Busatto G, Pilowsky L, Costa D, Mertens J, Terriere D, Ell P, Mulligan R, Travis M, Leysen J, Gacinovic S, Waddington W, Lingford-Hughes A, Kerwin R (1997) Initial evaluation of 123I-5-I-R91150, a selective 5-HT2A ligand for single-photon emission tomography, in healthy subjects. Eur J Nucl Med 24:119–124PubMedCrossRefGoogle Scholar
  7. Coccaro E, Kavoussi R, Cooper T, Hauger R (1997) Central serotonin activity and aggression: inverse relationship with prolactin response to d-fenfluramine, but not CSF 5-HIAA concentration, in human subjects. Am J Psychiatry 154:1430–1435PubMedGoogle Scholar
  8. DSM-IV-TR (Diagnostic and Statistical Manual of Mental Disorders DSM-IV-TR) (2000), American Psychiatric Association, Washington DCGoogle Scholar
  9. Freud S (1975) Beyond the pleasure principle. WW Norton, New YorkGoogle Scholar
  10. Galynker II, Cai J, Ongseng F, Finestone H, Dutta E, Serseni D (1998) Hypofrontality and negative symptoms in major depressive disorder. J Nucl Med 39:608–612PubMedGoogle Scholar
  11. Kandel E (1999) Biology and the future of psychoanalysis: an new intellectual framework for psychiatry revisited. Am J Psychiatry 156:505–524PubMedGoogle Scholar
  12. Manes F, Sahakian B, Clark L, Rogers R, Antoun N, AItken M, Robbins T (2002) Decision-making processes following damage to the prefrontal cortex. Brain 125:624–639PubMedCrossRefGoogle Scholar
  13. Medved V, Petrovic R, Isgum V, Szirovicza L, Hotujac L (2001) Similarities in the pattern of regional brain dysfunction in negative schizophrenia and unipolar depression: a single photon emission-computed tomography and auditory evoked potentials study. Prog Neuropsychopharmacol Biol Psychiatry 25:993–1009PubMedCrossRefGoogle Scholar
  14. Mertens J, Terriere D, Sipido V, Van Gommeren W, Janssen P, Leysen J (1994) Radiosynthesis of a new radio-iodinated ligand for serotonin-5HT(2)-receptors, a promising tracer for gamma-emission tomography. J Lab Comp Radiopharm 34:795–806CrossRefGoogle Scholar
  15. Mitchell P, Smythe G (1990) Hormonal responses to fenfluramine in depressed and control subjects. J Affect Disord 19:43–51PubMedCrossRefGoogle Scholar
  16. Monteleone P, Brambilla F, Bortolotti F, La Rocca A, Maj M (1998) Prolactin response to d-fenfluramine is blunted in people with anorexia nervosa. Br J Psychiatry 172:438–442CrossRefGoogle Scholar
  17. Mountjoy C, Roth M (1982) Studies on the relationship between depression and anxiety states, part I. J Affect Dis 4:127–147PubMedCrossRefGoogle Scholar
  18. O’Keane V, Moloney E, O’Neill H, O’Connor A, Smith C, Dinan T (1992) Blunted prolactin responses to d-fenfluramine in sociopathy: evidence for subsensitivity of central serotonergic function. Br J Psychiatry 160:643–646PubMedCrossRefGoogle Scholar
  19. Peremans K, Audenaert K, Coopman F, Blanckaert P, Jacobs F, Otte A, Verschooten F, Van Bree H, Van Heeringen K, Mertens J, Slegers G, Dierckx R (2003) Estimates of regional cerebral blood flow and 5-HT2A receptor density in impulsive, aggressive dogs with (99m)Tc-ECD and (123)I-5-I-R91150. Eur J Nucl Med Molec Imag 30:1538–1546CrossRefGoogle Scholar
  20. Van Heeringen C, Audenaert K, Van Laere K, Dumont F, Slegers G, Mertens J, Dierckx R (2003) Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. J Aff Disord 74:149–158CrossRefGoogle Scholar
  21. Van Praag H (1993) Make-believes in psychiatry or the perils of progress. Brünner-Mazel, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Kurt Audenaert
    • 1
  • Andreas Otte
    • 2
  • Kathelijne Peremans
    • 3
  • C. van Heeringen
  • Rudi Dierckx
    • 2
  1. 1.Department of Psychiatry and Medical PsychologyUniversity Hospital GhentGentBelgium
  2. 2.Division of Nuclear MedicineUniversity Hospital GhentGentBelgium
  3. 3.Department of Medical ImagingFaculty of Veterinary MedicineMerelbekeBelgium

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