Antenatal Cerebral Pathologies of Infectious Origin

  • Catherine Garel


Cytomegalovirus (CMV) infection is the most frequent congenital infection; it affects 0.5%–2.5% of live births [1]. Most symptomatic forms arise after a maternal primary infection; the infections arising after reactivation or reinfection are almost always asymptomatic [2]. Among the affected children, the mortality rate can reach 30% [1]. In the surviving children, the most serious sequelae are neurological. Therefore, these neurological complications should be carefully sought in antenatal imaging. Disorders such as neurosensorial hearing loss and chorioretinitis cannot be screened out in antenatal examinations. For this reason, one primarily has to look for direct signs of cerebral involvement, whether or not these are associated with other abnormalities reminiscent of fetal infection: ascites, cardiomegaly, pleural effusion, subcutaneous oedema, intrauterine growth restriction, oligo- or hydramnios, and thick placenta.


Ventricular Dilatation Cytomegalovirus Infection Cerebellar Hypoplasia Congenital Toxoplasmosis Germinal Matrix 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Catherine Garel
    • 1
  1. 1.Department of Pediatric ImagingHôpital Robert DebréParis Cedex 19France

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