One-Dimensional Microarrays for Genetic Testing and Diagnostics

Abstract

One-dimensional DNA microarrays with integrated index are presented. The microarrays explore one-dimensional format on flexible polymer substrates. This linear array approach offers advantages over the glass slide based two-dimensional arrays for low to medium throughput applications in genetic testing and diagnostics and environmental monitoring. For example the arrays can be made into a small volume by bending and folding of the flexible polymer substrate and thus reduce the amount of analyte required for bio-analysis. The integrated index eliminates the need for a separate barcode scanner, as it can be read out using the same scanner as for the arrays. We have demonstrated one-dimensional microarrays using oligonucleotides and PCR products of DNA fragments and polymer membrane strips.