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Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms

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Maturation Phenomenon in Cerebral Ischemia V

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Abstract

Brain damage induced by focal interruption of blood flow can be differentiated in two pathophysiologically different categories: a hemodynamic type of injury, resulting in primary necrotic brain damage, and a molecular type of injury which leads to delayed or secondary brain injury [15]. Primary necrotic brain injury occurs when blood flow declines - and remains - below the threshold of energy failure. In anaesthetized laboratory animals, this threshold gradually increases from about 15% of control shortly after the onset of ischemia to about 30% after several hours of vascular occlusion [29].

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Authors
  1. K.-A. Hossmann
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  2. R. Hata
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  3. K. Maeda
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  4. T. Trapp
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  5. G. Mies
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Editor information

Editors and Affiliations

  1. Office of Stroke Research, Foothills Medical Centre, Rm 1162, 1403-29 Street N.W., Calgary, Alberta, T2N 2T9, Canada

    Alastair M. Buchan

  2. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shu, Tokyo, 180-0023, Japan

    Umeo Ito

  3. Department of Psychology, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada

    Fred Colbourne

  4. Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113, Tokyo, Japan

    Toshihiko Kuroiwa

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, Maryland, 20892-4128, USA

    Igor Klatzo

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© 2004 Springer-Verlag Berlin Heidelberg

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Hossmann, KA., Hata, R., Maeda, K., Trapp, T., Mies, G. (2004). Transgenic Mutants for the Investigation of Molecular Stroke Mechanisms. In: Buchan, A.M., Ito, U., Colbourne, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18713-1_7

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  • DOI: https://doi.org/10.1007/978-3-642-18713-1_7

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