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Sphingolipids Metabolism Following Cerebral Ischemia

  • Conference paper
Book cover Maturation Phenomenon in Cerebral Ischemia V

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Abstract

It has been well known that ischemic insults induced the hydrolytic breakdown of polyphosphoinositides by calcium-dependent phospholipase C, and diacylglycerol (DAG) was hydrolyzed to free fatty acids (FFAs) by DAG lipase [1, 2, 11, 22, 26]. The composition of FFAs consists mainly of stearic (C18:0) and arachidonic acids (C20:4). These processes are thought to act at early phase of the ischemia. Prolonged ischemia induces the degradation of membrane phospholipids, and the level of various phospholipids decrease at late phase of the ischemia. To determine a therapeutic time window of the ischemic penumbra, it is essential to evaluate the time course of the degradation of glycerophospholipids.

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Author information

Authors and Affiliations

  1. Department of Neurosurgery, University Hospital, University School of Medicine, Mizonokuchi, Teikyo

    Masaru Kubota & Hitoshi Nakayama

  2. Department of Neurosurgery, Teikyo

    Makoto Nakane, Tadayoshi Nakagomi & Akira Tamura

  3. First Department of Biochemistry, Teikyo University, School of Medicine, Teikyo

    Harumi Hisaki, Hiroyuki Shimasaki & Nobuo Ueta

Authors
  1. Masaru Kubota
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  2. Makoto Nakane
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  3. Tadayoshi Nakagomi
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  4. Hitoshi Nakayama
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  5. Akira Tamura
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  6. Harumi Hisaki
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  7. Hiroyuki Shimasaki
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  8. Nobuo Ueta
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Editor information

Editors and Affiliations

  1. Office of Stroke Research, Foothills Medical Centre, Rm 1162, 1403-29 Street N.W., Calgary, Alberta, T2N 2T9, Canada

    Alastair M. Buchan

  2. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shu, Tokyo, 180-0023, Japan

    Umeo Ito

  3. Department of Psychology, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada

    Fred Colbourne

  4. Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113, Tokyo, Japan

    Toshihiko Kuroiwa

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, Maryland, 20892-4128, USA

    Igor Klatzo

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© 2004 Springer-Verlag Berlin Heidelberg

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Kubota, M. et al. (2004). Sphingolipids Metabolism Following Cerebral Ischemia. In: Buchan, A.M., Ito, U., Colbourne, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18713-1_25

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  • DOI: https://doi.org/10.1007/978-3-642-18713-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40874-1

  • Online ISBN: 978-3-642-18713-1

  • eBook Packages: Springer Book Archive

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