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Brain Genomic Responses to Ischemic Stroke, Hemorrhage, Seizures, Hypoglycemia and Hypoxia

  • Conference paper
Book cover Maturation Phenomenon in Cerebral Ischemia V

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Abstract

RNA expression in rat brain was examined one day following ischemic stroke, intracerebral hemorrhage, kainate-induced seizures, insulin-induced hypoglycemia, and hypoxia. Rat oligonucleotide microarrays were used to compare expression of over 8000 transcripts for these brain injuries compared to sham operated and untouched controls. Of the genes induced one day following ischemia, hemorrhage, and hypoglycemia, approximately half were unique for each condition suggesting unique components of the responses to each of the injuries. A significant number of the genes were immune-related, likely representing responses to dying cells in ischemia, to blood in hemorrhage, and to neuronal death following hypoglycemia. All of the genes induced by kainate were also induced either by ischemia, hemorrhage or hypoglycemia. This strongly supports the concept that excitotoxicity plays a role in ischemia, intracerebral hemorrhage and hypoglycemia. In contrast, there was only a single gene that was down-regulated by all of the injury conditions suggesting there is not a common gene down-regulation response to injury.

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References

  1. Abe H, Nowak TS Jr (1996) The stress response and its role in cellular defense mechanisms after ischemia. Adv Neurol 71:451–466

    PubMed  CAS  Google Scholar 

  2. Agapova OA, Ricard CS, Salvador-Silva M, Hernandez MR (2001) Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in human optic nerve head astrocytes. Glia 33:205–216

    Article  PubMed  CAS  Google Scholar 

  3. Agassandian C, Plantier M, Fattoum A, Represa A, der Terrossian E (2000) Subcellular distribution of calponin and caldesmon in rat hippocampus. Brain Res 887:444–449

    Article  PubMed  CAS  Google Scholar 

  4. Ali C, Docagne F, Nicole O, Lesne S, Toutain J, Young A, Chazalviel L, Divoux D, Caly M, Cabal P, Derlon JM, MacKenzie ET, Buisson A, Vivien D (2001) Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress? J Cereb Blood Flow Metab 21:820–827

    Article  PubMed  CAS  Google Scholar 

  5. Anders J, Kjar S, Ibanez CF (2001) Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site. J Biol Chem 276:35808–35817

    Article  PubMed  CAS  Google Scholar 

  6. Andersson PB, Perry VH, Gordon S (1991) The CNS acute inflammatory response to excito-toxic neuronal cell death. Immunol Lett 30:177–181

    Article  PubMed  CAS  Google Scholar 

  7. Anguelova E, Boularand S, Nowicki JP, Benavides J, Smirnova T (2000) Up-regulation of genes involved in cellular stress and apoptosis in a rat model of hippocampal degeneration. J Neurosci Res 59:209–217

    Article  PubMed  CAS  Google Scholar 

  8. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, Koo GC, Calderwood SK (2000) HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 6:435–442

    Article  PubMed  CAS  Google Scholar 

  9. Auer RN, Kalimo H, Olsson Y, Siesjo BK (1985) The temporal evolution of hypoglycemic brain damage. I. Light-and electron-microscopic findings in the rat cerebral cortex. Acta Neuropathol (Berl) 67:13–24

    Article  CAS  Google Scholar 

  10. Auer RN, Olsson Y, Siesjo BK (1984) Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study. Diabetes 33:1090–1098

    Article  PubMed  CAS  Google Scholar 

  11. Barone FC, Feuerstein GZ (1999) Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19:819–834

    Article  PubMed  CAS  Google Scholar 

  12. Bergeron M, Gidday JM, Yu AY, Semenza GL, Ferriero DM, Sharp FR (2000) Role of hypoxiainducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann Neurol 48:285–296

    Article  PubMed  CAS  Google Scholar 

  13. Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR (1999) Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci 11:4159–4170

    Article  PubMed  CAS  Google Scholar 

  14. Bernstein HG, Muller M (1999) The cellular localization of the L-ornithine decarboxylase/polyamine system in normal and diseased central nervous systems. Frog Neurobiol 57:485–505

    Article  CAS  Google Scholar 

  15. Bittigau P, Ikonomidou C (1997) Glutamate in neurologic diseases. J Child Neurol 12:471–485

    Article  PubMed  CAS  Google Scholar 

  16. Bona E, Andersson AL, Blomgren K, Gilland E, Puka-Sundvall M, Gustafson K, Hagberg H (1999) Chemokine and inflammatory cell response to hypoxia-ischemia in immature rats. Pediatr Res 45:500–509

    Article  PubMed  CAS  Google Scholar 

  17. Brown PO, Botstein D (1999) Exploring the new world of the genome with DNA microarrays. Nat Genet 21:33–37

    Article  PubMed  CAS  Google Scholar 

  18. Burda J, Martin ME, Gottlieb M, Chavko M, Marsala J, Alcazar A, Pavon M, Fando JL, Salinas M (1998) The intraischemic and early reperfusion changes of protein synthesis in the rat brain. eIF-2 alpha kinase activity and role of initiation factors eIF-2 alpha and eIF-4E. J Cereb Blood Flow Metab 18:59–66

    Article  PubMed  CAS  Google Scholar 

  19. Campagne MV, Thibodeaux H, van Bruggen N, Cairns B, Lowe DG (2000) Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion. J Neurosci 20:5200–5207

    PubMed  CAS  Google Scholar 

  20. Carroll SL, Frohnert PW (1998) Expression of JE (monocyte chemoattractant protein-1) is induced by sciatic axotomy in wild type rodents but not in C57BL/Wld(s) mice. J Neuropathol Exp Neurol 57:915–930

    Article  PubMed  CAS  Google Scholar 

  21. Chan YL, Suzuki K, Olvera J, Wool IG (1993) Zinc finger-like motifs in rat ribosomal proteins S27 and 529. Nucleic Acids Res 21:649–655

    Article  PubMed  CAS  Google Scholar 

  22. Charriaut-Marlangue C, Richard E, Ben-AH Y (1999) DNA damage and DNA damage-inducible protein Gadd45 following ischemia in the P7 neonatal rat. Brain Res Dev Brain Res 116:133–140

    Article  PubMed  CAS  Google Scholar 

  23. Chen BP, Wolfgang CD, Hai T (1996) Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol 16:1157–1168

    PubMed  Google Scholar 

  24. Chen J, Uchimura K, Stetler RA, Zhu RL, Nakayama M, Jin K, Graham SH, Simon RP (1998) Transient global ischemia triggers expression of the DNA damage-inducible gene GADD45 in the rat brain. J Cereb Blood Flow Metab 18:646–657

    Article  PubMed  CAS  Google Scholar 

  25. Choi DW (1998) Antagonizing excitotoxicity: a therapeutic strategy for stroke? Mt Sinai J Med 65:133–138

    PubMed  CAS  Google Scholar 

  26. Choi DW (1988) Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623–634

    Article  PubMed  CAS  Google Scholar 

  27. Collins VP (1995) Gene amplification in human gliomas. Glia 15:289–296

    Article  PubMed  CAS  Google Scholar 

  28. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991) Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368–6371

    Article  PubMed  CAS  Google Scholar 

  29. del Zoppo GJ, Ginis I, Hallenbeck JM, Iadecola C, Wang X, Feuerstein GZ (2000) Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol 10:95–112

    Article  PubMed  Google Scholar 

  30. del Zoppo GJ, Becker KJ, Hallenbeck JM (2001) Inflammation after stroke: is it harmful? Arch Neurol 58:669–672

    Article  PubMed  Google Scholar 

  31. Dever TE (1999) Translation initiation: adept at adapting. Trends Biochem Sci 24:398–403

    Article  PubMed  CAS  Google Scholar 

  32. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391–397

    Article  PubMed  CAS  Google Scholar 

  33. Doble A (1999) The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther 81:163–221

    Article  PubMed  CAS  Google Scholar 

  34. Eberhard DA, Brown MD, Van den Berg SR (1994) Alterations of annexin expression in pathological neuronal and glial reactions. Immunohistochemical localization of annexins I, II (p36 and pl l subunits), IV, and VI in the human hippocampus. Am J Pathol 145:640–649

    CAS  Google Scholar 

  35. Eklind S, Mallard C, Leverin AL, Gilland E, Blomgren K, Mattsby-Baltzer I, Hagberg H (2001) Bacterial endotoxin sensitizes the immature brain to hypoxic-ischaemic injury. Eur J Neurosci 13:1101–1106

    Article  PubMed  CAS  Google Scholar 

  36. Ellison JA, Barone FC, Feuerstein GZ (1999) Matrix remodeling after stroke. De novo expression of matrix proteins and integrin receptors. Ann NY Acad Sci 890:204–222

    Article  PubMed  CAS  Google Scholar 

  37. Esch F, Lin KI, Hills A, Zaman K, Baraban JM, Chatterjee S, Rubin L, Ash DE, Ratan RR (1998) Purification of a multipotent antideath activity from bovine liver and its identification as arginase: nitric oxide-independent inhibition of neuronal apoptosis. J Neurosci 18:4083–4095

    PubMed  CAS  Google Scholar 

  38. Fabunmi RP, Wigley WC, Thomas PJ, DeMartino GN (2001) Interferon gamma regulates accumulation of the proteasome activator PA28 and immunoproteasomes at nuclear PML bodies. J Cell Sci 114:29–36

    PubMed  CAS  Google Scholar 

  39. Ferhat L, Charton G, Represa A, Ben-AH Y, der Terrossian E, Khrestchatisky M (1996) Acidic calponin cloned from neural cells is differentially expressed during rat brain development. Eur J Neurosci 8:1501–1509

    Article  PubMed  CAS  Google Scholar 

  40. Finsen BR, Jorgensen MB, Diemer NH, Zimmer J (1993) Microglial MHC antigen expression after ischemic and kainic acid lesions of the adult rat hippocampus. Glia 7:41–49

    Article  PubMed  CAS  Google Scholar 

  41. Garcia-Montero AC, Vasseur S, Giono LE, Canepa E, Moreno S, Dagorn JC, Iovanna JL (2001) Transforming growth factor beta-1 enhances Smad transcriptional activity through activation of p8 gene expression. Biochem J 357:249–253

    Article  PubMed  CAS  Google Scholar 

  42. Gingrich MB, Junge CE, Lyuboslaysky P, Traynelis SF (2000) Potentiation of NMDA receptor function by the serine protease thrombin. J Neurosci 20:4582–4595

    PubMed  CAS  Google Scholar 

  43. Hallenbeck JM (1996) Significance of the inflammatory response in brain ischemia. Acta Neurochir Suppl (Wien) 66:27–31

    CAS  Google Scholar 

  44. Hankey GJ, Eikelboom JW (2001) Homocysteine and stroke. Curr Opin Neurol 14:95–102

    Article  PubMed  CAS  Google Scholar 

  45. Hao J, Ju H, Zhao S, Junaid A, Scammell-La Fleur T, Dixon IM (1999) Elevation of expression of Smads 2, 3, and 4, decortin and TGF-beta in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol 31:667–678

    Article  PubMed  CAS  Google Scholar 

  46. Hertz L, Yu AC, Kala G, Schousboe A (2000) Neuronal-astrocytic and cytosolic-mitochondrial metabolite trafficking during brain activation, hyperammonemia and energy deprivation. Neurochem Int 37:83–102

    Article  PubMed  CAS  Google Scholar 

  47. Hossmann KA (1994) Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36:557–565

    Article  PubMed  CAS  Google Scholar 

  48. Hubacek JA, Rothe G, Pit’ha J, Skodova Z, Stanek V, Poledne R, Schmitz G (1999) C(-260)—> T polymorphism in the promoter of the CD14 monocyte receptor gene as a risk factor for myocardial infarction. Circulation 99:218–220

    Article  Google Scholar 

  49. Itoh S, Itoh F, Goumans MJ, Ten Dijke P (2000) Signaling of transforming growth factor-beta family members through Smad proteins. Eur J Biochem 267:6954–6967

    Article  PubMed  CAS  Google Scholar 

  50. Jenkinson CP, Grody WW, Cederbaum SD (1996) Comparative properties of arginases. Comp Biochem Physiol B Biochem Mol Biol 114:107–132

    Article  PubMed  CAS  Google Scholar 

  51. Jin K, Chen J, Kawaguchi K, Zhu RL, Stetler RA, Simon RP, Graham SH (1996) Focal ischemia induces expression of the DNA damage-inducible gene GADD45 in the rat brain. Neuroreport 7:1797–1802

    Article  PubMed  CAS  Google Scholar 

  52. Jin K, Mao XO, Eshoo MW, Nagayama T, Minam M, Simon RP, Greenberg DA (2001) Microarray analysis of hippocampal gene expression in global cerebral ischemia. Ann Neurol 50:93–103

    Article  PubMed  CAS  Google Scholar 

  53. Jing C, Beesley C, Foster CS, Chen H, Rudland PS, West DC, Fujii H, Smith, PH, Ke Y (2001) Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells. Cancer Res 61:4357–4364

    PubMed  CAS  Google Scholar 

  54. Johnson TD (1998) Polyamines and cerebral ischemia. Prog Drug Res 50:193–258

    Article  PubMed  CAS  Google Scholar 

  55. Kachra Z, Beaulieu E, Delbecchi L, Mousseau N, Berthelet F, Moumdjian R, Del Maestro R, Beliveau R (1999) Expression of matrix metalloproteinases and their inhibitors in human brain tumors. Clin Exp Metastasis 17:555–566

    Article  PubMed  CAS  Google Scholar 

  56. Kato H, Kogure K, Liu XH, Araki T, Itoyama Y (1996) Progressive expression of immunomolecules on activated microglia and invading leukocytes following focal cerebral ischemia in the rat. Brain Res 734:203–212

    Article  PubMed  CAS  Google Scholar 

  57. Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410:988–994

    Article  PubMed  CAS  Google Scholar 

  58. Koistinaho J, Hokfelt T (1997) Altered gene expression in brain ischemia. Neuroreport 8:1–8

    Google Scholar 

  59. Krueger AM, Armstrong JN, Plumier J, Robertson HA, Currie RW (1999) Cell specific expression of Hsp70 in neurons and glia of the rat hippocampus after hyperthermia and kainic acid-induced seizure activity. Brain Res Mol Brain Res 71:265–278

    Article  PubMed  CAS  Google Scholar 

  60. Ladd AN, Charlet N, Cooper TA (2001) The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Mol Cell Biol 21:1285–1296

    Article  PubMed  CAS  Google Scholar 

  61. Lebel E, Vallieres L, Rivest S (2000) Selective involvement of interleukin-6 in the transcriptional activation of the suppressor of cytokine signaling-3 in the brain during systemic immune challenges. Endocrinology 141:3749–3763

    Article  PubMed  CAS  Google Scholar 

  62. Lee JM, Zipfel GJ, Choi DW (1999) The changing landscape of ischaemic brain injury mechanisms. Nature 399:7–14

    Article  Google Scholar 

  63. Lee ML, Kuo FC, Whitmore GA, Sklar J (2000) Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations. Proc Natl Acad Sci USA 97:9834–9839

    Article  PubMed  CAS  Google Scholar 

  64. Lehrmann E, Christensen T, Zimmer J, Diemer NH, Finsen B (1997) Microglial and macrophage reactions mark progressive changes and define the penumbra in the rat neocortex and striatum after transient middle cerebral artery occlusion. J Comp Neurol 386:461–476

    Article  PubMed  CAS  Google Scholar 

  65. Leo CP, Pisarska MD, Hsueh At (2001) DNA array analysis of changes in preovulatory gene expression in the rat ovary. Biol Reprod 65:269–276

    Article  PubMed  CAS  Google Scholar 

  66. Lipshutz RJ, Fodor SP, Gingeras TR, Lockhart DJ (1999) High density synthetic oligonucleotide arrays. Nat Genet 21:20–24

    Article  PubMed  CAS  Google Scholar 

  67. Liu J, Bartels M, Lu A, Sharp FR (2001) Microglia/macrophages proliferate in striatum and neocortex but not in hippocampus after brief global ischemia that produces ischemic tolerance in gerbil brain. J Cereb Blood Flow Metab 21:361–373

    Article  PubMed  CAS  Google Scholar 

  68. Liu J, Solway K, Messing RO, Sharp FR (1998) Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils. J Neurosci 18:7768–7778

    PubMed  CAS  Google Scholar 

  69. Lockhart DJ, Barlow C (2001) Expressing what’s on your mind: DNA arrays and the brain. Nat Rev Neurosci 2:63–68

    Article  PubMed  CAS  Google Scholar 

  70. Marine JC, McKay C, Wang D, Topham DJ, Parganas E, Nakajima H, Pendeville H, Yasukawa H, Sasaki A, Yoshimura A, Ihle JN (1999) SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 98:617–627

    Article  PubMed  CAS  Google Scholar 

  71. Martin De La Vega C, Burda J, Nemethova M, Quevedo C, Alcazar A, Martin ME, Danielisova V, Fando JL, Salinas M (2001) Possible mechanisms involved in the down-regulation of translation during transient global ischaemia in the rat brain. Biochem J 357:819–826

    Article  PubMed  CAS  Google Scholar 

  72. Massa SM, Swanson RA, Sharp FR (1996) The stress gene response in brain. Cerebrovasc Brain Metab Rev 8:95–158

    CAS  Google Scholar 

  73. Matsuoka Y, Kitamura Y, Okazaki M, Sakata M, Tsukahara T, Taniguchi T (1998) Induction of heme oxygenase-1 and major histocompatibility complex antigens in transient forebrain ischemia. J Cereb Blood Flow Metab 18:824–832

    Article  PubMed  CAS  Google Scholar 

  74. Matsushita K, Meng W, Wang X, Asahi M, Asahi K, Moskowitz MA, Lo EH (2000) Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab 20:396–404

    Article  PubMed  CAS  Google Scholar 

  75. Mayne M, Ni W, Yan HJ, Xue M, Johnston JB, Del Bigio MR, Peeling J, Power C (2001) Antisense oligodeoxynucleotide inhibition of tumor necrosis factor-alpha expression is neuroprotective after intracerebral hemorrhage. Stroke 32:240–248

    Article  PubMed  CAS  Google Scholar 

  76. Meldrum BS (1993) Excitotoxicity and selective neuronal loss in epilepsy. Brain Pathol 3:405–412

    Article  PubMed  CAS  Google Scholar 

  77. Meldrum BS (1994) The role of glutamate in epilepsy and other CNS disorders. Neurology 44:14–23

    Google Scholar 

  78. Melillo RM, Santoro M, Ong SH, Billaud M, Fusco A, Hadari YR, Schlessinger J, Lax I (2001) Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase signaling cascade. Mol Cell Biol 21:4177–4187

    Article  PubMed  CAS  Google Scholar 

  79. Minami Y, Kawasaki H, Minami M, Tanahashi N, Tanaka K, Yahara I (2000) A critical role for the proteasome activator PA28 in the Hsp90-dependent protein refolding. J Biol Chem 275: 9055–9061

    Article  PubMed  CAS  Google Scholar 

  80. Mimics K, Middleton FA, Marquez A, Lewis DA, Levitt P (2000) Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28:53–67

    Article  Google Scholar 

  81. Miyazono K, ten Dijke P, Heldin CH (2000) TGF-beta signaling by Smad proteins. Adv Immunol 75:115–157

    Article  PubMed  CAS  Google Scholar 

  82. Nadeau S, Rivest S (2000) Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor kappa B activity in the brain during endotoxemia. J Neurosci 20:3456–3468

    PubMed  CAS  Google Scholar 

  83. Nimura T, Weinstein PR, Massa SM, Panter S, Sharp FR (1996) Heme oxygenase-1 (HO-1) protein induction in rat brain following focal ischemia. Brain Res Mol Brain Res 37:201–208

    Article  PubMed  CAS  Google Scholar 

  84. Obrenovitch TP, Richards DA (1995) Extracellular neurotransmitter changes in cerebral ischaemia. Cerebrovasc Brain Metab Rev 7:1–54

    PubMed  CAS  Google Scholar 

  85. Pang L, Ye W, Che XM, Roessler BJ, Betz AL, Yang GY (2001) Reduction of inflammatory response in the mouse brain with adenoviral-mediated transforming growth factor-ssl expression. Stroke 32:544–552

    Article  PubMed  CAS  Google Scholar 

  86. Paschen W (1992) Polyamine metabolism in different pathological states of the brain. Mol Chem Neuropathol 16:241–271

    Article  PubMed  CAS  Google Scholar 

  87. Paschen W (1996) Disturbances of calcium homeostasis within the endoplasmic reticulum may contribute to the development of ischemic-cell damage. Med Hypotheses 47:283–288

    Article  PubMed  CAS  Google Scholar 

  88. Paschen W, Gissel C, Linden T, Althausen S, Doutheil J (1998) Activation of gadd153 expression through transient cerebral ischemia: evidence that ischemia causes endoplasmic reticulum dysfunction. Brain Res Mol Brain Res 60:115–122

    Article  PubMed  CAS  Google Scholar 

  89. Pestova TV, Kolupaeva VG, Lomakin IB, Pilipenko EV, Shatsky IN, Agol VI, Hellen CU (2001) Molecular mechanisms of translation initiation in eukaryotes. Proc Natl Acad Sci USA 98: 7029–7036

    Article  PubMed  CAS  Google Scholar 

  90. Plantier M, Fattoum A, Menn B, Ben-Ari Y, der Terrossian E, Represa A (1999) Acidic calponin immunoreactivity in postnatal rat brain and cultures: subcellular localization in growth cones, under the plasma membrane and along actin and glial filaments. Eur J Neurosci 11:2801–2812

    Article  PubMed  CAS  Google Scholar 

  91. Plumier JC, David JC, Robertson HA, Currie RW (1997) Cortical application of potassium chloride induces the low-molecular weight heat shock protein (HSP27) in astrocytes. J Cereb Blood Flow Metab 17:781–790

    Article  PubMed  CAS  Google Scholar 

  92. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B (1998) Defective LPS signaling in C3H/HeJ and C57BL/1OScCr mice: mutations in T1r4 gene. Science 282:2085–2088

    Article  PubMed  CAS  Google Scholar 

  93. Potempa J, Enghild JJ, Travis J (1995) The primary elastase inhibitor (elastasin) and trypsin inhibitor (contrapsin) in the goat are serpins related to human alpha 1-anti-chymotrypsin. Biochem J 306:191–197

    PubMed  CAS  Google Scholar 

  94. Prasad SS, Cynader MS (1994) Identification of cDNA clones expressed selectively during the critical period for visual cortex development by subtractive hybridization. Brain Res 639:73–84

    Article  PubMed  CAS  Google Scholar 

  95. Pugin J, Heumann ID, Tomasz A, Kravchenko VV, Akamatsu Y, Nishijima M, Glauser MP, Tobias PS, Ulevitch RJ (1994) CD14 is a pattern recognition receptor. Immunity 1:509–516

    Article  PubMed  CAS  Google Scholar 

  96. Raghavendra Rao VL, Dogan A, Bowen KK, Dempsey RJ (2000) Traumatic brain injury leads to increased expression of peripheral-type benzodiazepine receptors, neuronal death, and activation of astrocytes and microglia in rat thalamus. Exp Neurol 161:102–114

    Article  PubMed  CAS  Google Scholar 

  97. Rajdev S, Hara K, Kokubo Y, Mestril R, Dillmann W, Weinstein PR, Sharp FR (2000) Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction. Ann Neu-rol 47:782–791

    Article  CAS  Google Scholar 

  98. Rao VL, Bowen KK, Rao AM, Dempsey RJ (2001) Up-regulation of the peripheral-type benzodiazepine receptor expression. J Neurosci Res 64:493–500

    Article  PubMed  CAS  Google Scholar 

  99. Rechsteiner M, Realini C, Ustrell V (2000) The proteasome activator 11 S REG (PA28) and class I antigen presentation. Biochem J 345 Pt 1:1–15

    Article  Google Scholar 

  100. Regan RF, Panter SS (1996) Hemoglobin potentiates excitotoxic injury in cortical cell culture. J Neurotrauma 13:223–231

    PubMed  CAS  Google Scholar 

  101. Roberts AB, Piek E, Bottinger EP, Ashcroft G, Mitchell JB, Flanders KC (2001) Is smad3 a major player in signal transduction pathways leading to fibrogenesis? Chest 120:S43–S47

    Article  Google Scholar 

  102. Rothwell NJ, Luheshi GN (2000) Interleukin 1 in the brain: biology, pathology and therapeutic target [In Process Citation]. Trends Neurosci 23:618–625

    Article  PubMed  CAS  Google Scholar 

  103. Saarma M (2000) GDNF - a stranger in the TGF-beta superfamily? Eur J Biochem 267:6968–6971

    Article  PubMed  CAS  Google Scholar 

  104. Schiffer M, von Gersdorff G, Bitzer M, Susztak K, Bottinger EP (2000) Smad proteins and transforming growth factor-beta signaling. Kidney Int 58 Suppl 77:S45–52

    Article  CAS  Google Scholar 

  105. Schmidt-Kastner R, Zhao W, Truettner J, Belayev L, Busto R, Ginsberg MD (1998) Pixel-based image analysis of HSP7O, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates. Brain Res Mol Brain Res 63:79–97

    Article  PubMed  CAS  Google Scholar 

  106. Schumann RR, Leong SR, Flaggs GW, Gray PW, Wright SD, Mathison JC, Tobias PS, Ulevitch RJ (1990) Structure and function of lipopolysaccharide binding protein. Science 249:1429–1431

    Article  PubMed  CAS  Google Scholar 

  107. Semenza GL (1999) Perspectives on oxygen sensing. Cell 98:281–284

    Article  PubMed  CAS  Google Scholar 

  108. Semenza GL (1999) Regulation of mammalian 02 homeostasis by hypoxia-inducible factor 1. Annu Rev Cell Dev Biol 15:551–578

    Article  PubMed  CAS  Google Scholar 

  109. Semenza GL (2000) Expression of hypoxia-inducible factor 1: mechanisms and consequences. Biochem Pharmacol 59:47–53

    Article  PubMed  CAS  Google Scholar 

  110. Sharp FR, Lu A, Tang Y, Millhorn DE (2000) Multiple molecular penumbras after focal cerebral ischemia. J Cereb Blood Flow Metab 20:1011–1032

    Article  PubMed  CAS  Google Scholar 

  111. Sharp FR, Massa SM, Swanson RA (1999) Heat-shock protein protection. Trends Neurosci 22:97–99

    Article  PubMed  CAS  Google Scholar 

  112. Shimada K, Watanabe Y, Mokuno H, Iwama Y, Daida H, Yamaguchi H (2000) Common polymorphism in the promoter of the CD14 monocyte receptor gene is associated with acute myocardial infarction in Japanese men. Am J Cardiol 86:682–684, A8

    Article  PubMed  CAS  Google Scholar 

  113. Simon RP, Cho H, Gwinn R, Lowenstein DH (1991) The temporal profile of 72-kDa heat-shock protein expression following global ischemia. J Neurosci 11:881–889

    PubMed  CAS  Google Scholar 

  114. Simon RP, Schmidley JW, Meldrum BS, Swan JH, Chapman AG (1986) Excitotoxic mechanisms in hypoglycaemic hippocampal injury. Neuropathol Appl Neurobiol 12:567–576

    Article  PubMed  CAS  Google Scholar 

  115. Simon RP, Swan JH, Griffiths T, Meldrum BS (1984) Blockade of N-methyl-D-aspartate receptors may protect against ischemic damage in the brain. Science 226:850–852

    Article  PubMed  CAS  Google Scholar 

  116. Soriano MA, Tessier M, Certa U, Gill R (2000) Parallel gene expression monitoring using oligonucleotide probe arrays of multiple transcripts with an animal model of focal ischemia. J Cereb Blood Flow Metab 20:1045–1055

    Article  PubMed  CAS  Google Scholar 

  117. Spector EB, Kern RM, Haggerty DF, Cederbaum SD (1985) Differential expression of multiple forms of arginase in cultured cells. Mol Cell Biochem 66:45–53

    Article  PubMed  CAS  Google Scholar 

  118. Stohwasser R, Salzmann U, Giesebrecht J, Kloetzel PM, Holzhutter HG (2000) Kinetic evidences for facilitation of peptide channelling by the proteasome activator PA28. Eur J Biochem 267:6221–6230

    Article  PubMed  CAS  Google Scholar 

  119. Stoll G, Jander S, Schroeter M (1998) Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149–171

    Article  PubMed  CAS  Google Scholar 

  120. Streit WJ (2000) Microglial response to brain injury: a brief synopsis. Toxicol Pathol 28:28–30

    Article  PubMed  CAS  Google Scholar 

  121. Sullivan JM, Alousi SS, Hikade KR, Bahu NJ, Rafols JA, Krause GS, White BC (1999) Insulin induces dephosphorylation of eukaryotic initiation factor 2alpha and restores protein synthesis in vulnerable hippocampal neurons after transient brain ischemia. J Cereb Blood Flow Metab 19:1010–1019

    Article  PubMed  CAS  Google Scholar 

  122. Tanaka N, Sasahara M, Ohno M, Higashiyama S, Hayase Y, Shimada M (1999) Heparin-binding epidermal growth factor-like growth factor mRNA expression in neonatal rat brain with hypoxic/ischemic injury. Brain Res 827:130–138

    Article  PubMed  CAS  Google Scholar 

  123. Thomas EA, Alvarez CE, Sutcliffe JG (2000) Evolutionarily distinct classes of S27 ribosomal proteins with differential mRNA expression in rat hypothalamus. J Neurochem 74:2259–2267

    Article  PubMed  CAS  Google Scholar 

  124. Tsai PJ, Huang PC (2000) Circadian variations in plasma and erythrocyte glutamate concentrations in adult men consuming a diet with and without added monosodium glutamate. J Nutr 130:1002S–1004S

    PubMed  CAS  Google Scholar 

  125. Turner CP, Bergeron M, Matz P, Zegna A, Noble LJ, Panter SS, Sharp FR (1998) Heme oxygenase-1 is induced in glia throughout brain by subarachnoid hemoglobin. J Cereb Blood Flow Metab 18:257–273

    Article  PubMed  CAS  Google Scholar 

  126. Unkelbach K, Gardemann A, Kostrzewa M, Philipp M, Tillmanns H, Haberbosch W (1999) A new promoter polymorphism in the gene of lipopolysaccharide receptor CD14 is associated with expired myocardial infarction in patients with low atherosclerotic risk profile. Arterioscler Thromb Vasc Biol 19:932–938

    Article  PubMed  CAS  Google Scholar 

  127. Van Lookeren Campagne M, Thibodeaux H, Van Bruggen N, Cairns B, Gerlai R, Palmer JT, Williams SP, Lowe DG (1999) Evidence for a protective role of metallothionein-1 in focal cerebral ischemia. Proc Natl Acad Sci USA 96:12870–12875

    Article  Google Scholar 

  128. Verrecchia F, Chu ML, Mauviel A (2001) Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 276:17058–17062

    Article  PubMed  CAS  Google Scholar 

  129. Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE (1998) Early metabolic alterations in edematous perihematomal brain regions following experimental intracerebral hemorrhage. J Neurosurg 88:1058–1065

    Article  PubMed  CAS  Google Scholar 

  130. Wagner KR, Xi G, Hua Y, Kleinholz M, de Courten-Myers GM, Myers RE, Broderick JP, Brott TG (1996) Lobar intracerebral hemorrhage model in pigs: rapid edema development in perihematomal white matter. Stroke 27:490–497

    Article  PubMed  CAS  Google Scholar 

  131. Wang H, Zhan Y, Xu L, Feuerstein GZ, Wang X (2001) Use of suppression subtractive hybridization for differential gene expression in stroke: discovery of CD44 gene expression and localization in permanent focal stroke in rats. Stroke 32:1020–1027

    Article  PubMed  CAS  Google Scholar 

  132. Wang X, Barone FC, White RF, Feuerstein GZ (1998) Subtractive cloning identifies tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) increased gene expression following focal stroke. Stroke 29:516–520

    Article  PubMed  CAS  Google Scholar 

  133. Wang X, Louden C, Yue TL, Ellison JA, Barone FC, Solleveld HA, Feuerstein GZ (1998) Delayed expression of osteopontin after focal stroke in the rat. J Neurosci 18:2075–2083

    PubMed  CAS  Google Scholar 

  134. Warner RL, Lewis CS, Beltran L, Younkin EM, Varani J, Johnson KJ (2001) The role of metalloelastase in immune complex-induced acute lung injury. Am J Pathol 158:2139–2144

    Article  PubMed  CAS  Google Scholar 

  135. Welman E, Colbeck JF, Selwyn AP, Fox KM, Orr I (1980) Plasma lysosomal enzyme activity in acute myocardial infarction and the effects of drugs. Adv Myocardiol 2:359–369

    PubMed  CAS  Google Scholar 

  136. Werner F, Jain MK, Feinberg MW, Sibinga NE, Pellacani A, Wiesel P, Chin MT, Topper JN, Perrella MA, Lee ME (2000) Transforming growth factor-beta 1 inhibition of macrophage activation is mediated via Smad3. J Biol Chem 275:36653–36658

    Article  PubMed  CAS  Google Scholar 

  137. Wessling-Resnick M (1999) Biochemistry of iron uptake. Crit Rev Biochem Mol Biol 34:285–314

    Article  PubMed  CAS  Google Scholar 

  138. Whitney LW, Becker KG, Tresser NJ, Caballero-Ramos CI, Munson PJ, Prabhu VV, Trent JM, McFarland HF, Biddison WE (1999) Analysis of gene expression in multiple sclerosis lesions using cDNA microarrays. Ann Neurol 46:425–428

    Article  PubMed  CAS  Google Scholar 

  139. Wilson JX (1997) Antioxidant defense of the brain: a role for astrocytes. Can J Physiol Pharmacol 75:1149–1163

    Article  PubMed  CAS  Google Scholar 

  140. Wong JM, Mafune K, Yow H, Rivers EN, Ravikumar TS, Steele GD Jr, Chen LB (1993) Ubiquitin-ribosomal protein S27a gene overexpressed in human colorectal carcinoma is an early growth response gene. Cancer Res 53:1916–1920

    PubMed  CAS  Google Scholar 

  141. Wright SD (1999) Toll, a new piece in the puzzle of innate immunity. J Exp Med 189:605–609

    Article  PubMed  CAS  Google Scholar 

  142. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC (1990) CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431–1433

    Article  PubMed  CAS  Google Scholar 

  143. Xian CJ, Zhou XF (2000) Roles of transforming growth factor-alpha and related molecules in the nervous system. Mol Neurobiol 20:157–183

    Article  Google Scholar 

  144. Yamashima T (2000) Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates. Prog Neurobiol 62:273–295

    Article  PubMed  CAS  Google Scholar 

  145. Yanagitani S, Miyazaki H, Nakahashi Y, Kuno K, Ueno Y, Matsushita M, Naitoh Y, Taketani S, Inoue K (1999) Ischemia induces metallothionein III expression in neurons of rat brain. Life Sci 64:707–715

    Article  PubMed  CAS  Google Scholar 

  146. Yang GY, Betz AL, Chenevert TL, Brunberg JA, Hoff JT (1994) Experimental intracerebral hemorrhage: relationship between brain edema, blood flow, and blood-brain barrier permeability in rats. J Neurosurg 81:93–102

    Article  PubMed  CAS  Google Scholar 

  147. Yawata M, Murata S, Tanaka K, Ishigatsubo Y, Kasahara M (2001) Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. Immunogenetics 53:119–129

    Article  PubMed  CAS  Google Scholar 

  148. Yonekawa M, Okabe T, Asamoto Y, Ohta M (1999) A case of hereditary ceruloplasmin deficiency with iron deposition in the brain associated with chorea, dementia, diabetes mellitus and retinal pigmentation: administration of fresh-frozen human plasma. Eur Neurol 42:157–162

    Article  PubMed  CAS  Google Scholar 

  149. Yoshimoto R, Hori M, Ozaki H, Karaki H (2000) Proteolysis of acidic calponin by mu-calpain. J Biochem (Tokyo) 128:1045–1049

    Article  CAS  Google Scholar 

  150. Zarow GJ, Karibe H, States BA, Graham SH, Weinstein PR (1997) Endovascular suture occlusion of the middle cerebral artery in rats: effect of suture insertion distance on cerebral blood flow, infarct distribution and infarct volume. Neurol Res 19:409–416

    PubMed  CAS  Google Scholar 

  151. Zhang X, Boulton AA, Yu PH (1996) Expression of heat shock protein-70 and limbic seizure-induced neuronal death in the rat brain. Eur J Neurosci 8:1432–1440

    Article  PubMed  CAS  Google Scholar 

  152. Zhang X, Gelowitz DL, Lai CT, Boulton AA, Yu PH (1997) Gradation of kainic acid-induced rat limbic seizures and expression of hippocampal heat shock protein-70. Eur J Neurosci 9:760–769

    Article  PubMed  CAS  Google Scholar 

  153. Zhao X, Yang Z, Qian M, Zhu X (2001) Interactions among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem Biophys Res Commun 280:513–517

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Neurology and Neuroscience Program, University of Cincinnati and Divisions of Molecular Developmental Biology and Informatics, Cincinnati, Ohio, 45267, USA

    Y. Tang, A. Lu & K. R. Wagner

  2. Children`s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio, 45267, USA

    B. J. Aronow

  3. Department of Neurology • Neuroscience Program, University of Cincinnati, Vontz Center for Molecular Studies, Room 2327, 3125 Eden Avenue, Cincinnati, OH, 45267-0536, USA

    F. R. Sharp

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  1. Y. Tang
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  2. A. Lu
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  3. B. J. Aronow
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  4. K. R. Wagner
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  5. F. R. Sharp
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Editors and Affiliations

  1. Office of Stroke Research, Foothills Medical Centre, Rm 1162, 1403-29 Street N.W., Calgary, Alberta, T2N 2T9, Canada

    Alastair M. Buchan

  2. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shu, Tokyo, 180-0023, Japan

    Umeo Ito

  3. Department of Psychology, University of Alberta, Edmonton, Alberta, T6G 2E9, Canada

    Fred Colbourne

  4. Department of Neuropathology Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku 113, Tokyo, Japan

    Toshihiko Kuroiwa

  5. Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, National Institutes of Health, Bethesda, Maryland, 20892-4128, USA

    Igor Klatzo

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Tang, Y., Lu, A., Aronow, B.J., Wagner, K.R., Sharp, F.R. (2004). Brain Genomic Responses to Ischemic Stroke, Hemorrhage, Seizures, Hypoglycemia and Hypoxia. In: Buchan, A.M., Ito, U., Colbourne, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia V. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18713-1_2

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  • DOI: https://doi.org/10.1007/978-3-642-18713-1_2

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  • Print ISBN: 978-3-540-40874-1

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