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Hormonwirkungen und Hormontherapie

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Book cover Männersprechstunde

Zusammenfassung

Im Alter sinken die Testosteronspiegel des Mannes schleichend. Bei einem nicht unerheblichen Anteil der älteren Männer fallen die Testosteronwerte in einen hypogonadalen Bereich. Dieser altersassoziierte Hypogonadismus ist von anderen Formen des Hypogonadismus abzugrenzen.

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Literatur

  • Abe H, Yamada N, Kamata K et al. (1998) Hypertension, hypertrigIyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. J Clin Invest 101: 1784–1788

    Article  PubMed  CAS  Google Scholar 

  • Barrett-Connor E, Von Muhlen DG, Kritz-Silverstein D (1999) Bioavailable testosterone and depressed mood in older men: The Ranch Bernardo Study. J Clin Endocrinol Metab 84: 573–577

    Article  PubMed  CAS  Google Scholar 

  • Basaria S, Dobs AS (2001) Hypogonadism and androgen replacment therapy in elderly men. Am J Med 110: 563–572

    Article  PubMed  CAS  Google Scholar 

  • Behre HM, Nieschlag E (2000) Testosteronsubstitution beim alternden Mann. Urologe A 39: 421–424

    Article  PubMed  CAS  Google Scholar 

  • Behre HM, Kliesch S, Leifke E, Link TM, Nieschlag E (1997) Long-term effect of testosterone therapy on bone mineral density in hypogonadal men. J Clin Endocrinol Metab 82: 2386–2390

    Article  PubMed  CAS  Google Scholar 

  • Bhasin S, Buckwalter JG (2001) Testosterone supplementation in older men: a rational idea whose time has not yet come. J Androl 22: 718–731

    PubMed  CAS  Google Scholar 

  • Boyanov MA, Boneva Z, Christov VG (2003) Testosterone supplementation in men with type 2 diabetes, visceral obesity and partial androgen deficiency. Aging Male 6: 1–7

    PubMed  CAS  Google Scholar 

  • Bross R, Javanbakht M, Bhasin S (1999) Anabolic interventions for aging-associated sarcopenia. J Clin Endocrinol Metab 84: 3420–3430

    Article  PubMed  CAS  Google Scholar 

  • Buena F, Swerdloff RS, Steiner BS et al. (1993) Sexual function does not change when serum testosterone levels are phamacologically varied within the normal male range. Fertil Steril 59: 1118–1123

    PubMed  CAS  Google Scholar 

  • English KM, Steeds RP, Jones TH, Diver MJ, Channer KS (2000) Lowdose transdermal testosterone therapy improves angina threshold in men with chronic stable angina: A randomized, doubleblind, placebo-controlled study. Circulation 102: 1906–1911

    Article  PubMed  CAS  Google Scholar 

  • Feldman H (2002) Age trends in the levels of serum testosterone and other hormones in the middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87: 589–598

    Article  PubMed  CAS  Google Scholar 

  • Froguel P, Velho G, Passa P, Cohen D (1993) Genetic determinants of type 2 diabetes mellitus: lessons learned from family studies. Diabete Metab 19: 1–10

    PubMed  CAS  Google Scholar 

  • Fukui M, Kitagawa Y, Nakamura N et al. (2003) Association between serum testosterone concentration and carotid atherosclerosis in men with type 2 diabetes. Diabetes Care 26: 1869–1873

    Article  PubMed  CAS  Google Scholar 

  • Gagnon DR, Zhang TJ, Brand FN, Kannel WB (1994) Hamatocrit and the risk of cardiovascular disease. The Framingham Study: 34-year follow-up. Am Heart J 127: 674–682

    Article  PubMed  CAS  Google Scholar 

  • Granata AR, Rochira V, Lerchl A, Marrama P, Carani C (1997) Relationship between sleep-related erections and testosterne levels in men. J Androl 18: 522–527

    PubMed  CAS  Google Scholar 

  • Guillausseau PJ, Tielmans D, Virally-Monod M, Assayag M (1997) Diabetes: from phenotypes to genotypes. Diabetes Metab 23 (Suppl2): 14–21

    PubMed  Google Scholar 

  • Haffner SM (1998) Epidemiology of type 2 diabetes: risk factors. Diabetes Care 21 (Suppl3): C3–6

    Article  PubMed  Google Scholar 

  • Haffner SM, Lehto S, Ronnemaa T, Pyorala K, Laakso M (1998) Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 339: 229–234

    Article  PubMed  CAS  Google Scholar 

  • Hajjar RR, Kaiser FE, Morley JE (1997) Outcomes of long-term testosterone replacment in older hypogonadale males: a retrospective analysis. J Clin Endocrinol Metab 82: 3793–3796

    Article  PubMed  CAS  Google Scholar 

  • Hamm L (1942) Testosterone propionate in the treatment of angina pectoris. J Clin Endocrinol 2: 325–328

    Article  Google Scholar 

  • Heinemann LAJ, Saad F, Thiele K, Wood-Dauphinee (2001) The aging males’ symptoms rating scale: cultural and linguistic validation into English. Aging Male 4: 14–22

    Google Scholar 

  • Jackson JA, Riggs MW, Spiekerman AM (1992) Testosterone deficiency as a risk factor for hip fractures in men: A case-control study. Am J Med Sci 304: 4–8

    Article  PubMed  CAS  Google Scholar 

  • Jaffe MD (1977) Effect of testosterone cypionate on postexercise ST segment depression. Br Heart J 39: 1217–1222

    Article  PubMed  CAS  Google Scholar 

  • Jockenhovel F (1996) Mannlicher Hypogonadismus. In: Allolio B, Schulte HM (Hrsg) Praktische Endokrinologie. Urban & Schwarzenberg, Miinchen, S 361–380

    Google Scholar 

  • Jockenhovel F (2001a) Androgenmangel des alteren Mannes — Was bringt die Testosteron-Substitution? Dtsch Med Wochenschr 126: 247–252

    Article  PubMed  CAS  Google Scholar 

  • Jockenhovel F (2001b) Diagnostik des mannlichen Hypogonadismus. J Lab Med 25: 365–372

    Google Scholar 

  • Jockenhovel F, Vogel E, Kreutzer M, Reinhardt W, Lederbogen S, Reinwein D (1996) Pharmacokinetics and pharmacodynamiCS of subcutaneous testosterone implants in hypogonadal men. Clin Endocrinol (Oxf) 45: 61–71

    Article  CAS  Google Scholar 

  • Jockenhovel F, Blum WF, Vogel E et al. (1997) Testosterone substitution normalizes elevated serum leptin levels in hypogonadal men. J Clin Endocrinol Metab 82: 2510–2513

    Article  PubMed  CAS  Google Scholar 

  • Kahn CR, Flier JS, Bar RS et al. (1976) The syndromes of insulin resistance and acanthosis nigricans. Insulin-receptor disorders in man. N Engl J Med 294: 739–745

    Article  PubMed  CAS  Google Scholar 

  • Katznelson L, Finkelstein JS, Schoenfeld DA, Rosenthal DI, Anderson EJ, Klibanski A (1996) Increase in bone density and lean body mass during testosterone administration in men with acquired hypogonadism. J Clin Endocrinol Metab 81: 4358–4365

    Article  PubMed  CAS  Google Scholar 

  • Kramer D, Raji A, Plutzky J (2003) Prediabetes mellitus and its links to atherosclerosis. Curr Diab Rep 3: 11–18

    Article  PubMed  Google Scholar 

  • Lamberts SW, van den Beld AW, van der Lely AJ (1997) The endocrinology of aging. Science 278: 419–424

    Article  PubMed  CAS  Google Scholar 

  • Lesser MA (1946) Testosterone propionate therapy in one hundred cases of angina pectoris. J Clin Endocrinol 19: 549–557

    Article  Google Scholar 

  • Maas D, Jochen A, Lalande B (1997) Age-related changes in male gonadal function. Drugs Aging 11: 45–60

    Article  PubMed  CAS  Google Scholar 

  • Marin P (1995) Testosterone and regional fat distribution. Obes Res 3 (Suppl4): 609S–612S

    PubMed  CAS  Google Scholar 

  • Marin P, Arver S (1998) Androgens and abdominal obesity. Baillieres Clin Endocrinol Metab 12: 441–451

    Article  PubMed  CAS  Google Scholar 

  • Marin P, Holmang S, Jonsson L et al. (1992) The effects oftestosterone treatment on body composition and metabolism in middle-aged obese men. Int JObes Relat Metab Disord 16: 991–997

    CAS  Google Scholar 

  • Marin P, Holmang S, Gustafsson C et al. (1993) Androgen treatment of abdominally obese men. Obes Res 1: 245–251

    PubMed  CAS  Google Scholar 

  • Marin P, Lonn L, Andersson B et al. (1996) Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosterone. J Clin Endocrinol Metab 81: 1018–1022

    Article  PubMed  CAS  Google Scholar 

  • Medici F, Hawa M, Lanari A, Pyke DA, Leslie RD (1999) Concordance rate for type diabetes mellitus in monozygotic twins: actuarial analysis. Diabetologia 42: 146–150

    Article  PubMed  CAS  Google Scholar 

  • Miralpeix M, Sun XJ, Backer JM, Myers MG Jr, Araki E, White MF (1992) Insulin stimulates tyrosine phosphorylation of mUltiple high molecular weight substrates in Fao hepatoma cells. Biochemistry 31: 9031–9039

    Article  PubMed  CAS  Google Scholar 

  • Morales A, Heaton JP, Carson CC (2000) Andropause: A misnomer for a true clinical entity. J Uro 1163: 705–712

    Google Scholar 

  • Morley JE, Perry HM (2000) Androgen deficiency in aging men: role of testosterone replcacment therapy. J Lab Clin Med 135: 370–378

    Article  PubMed  CAS  Google Scholar 

  • Morley JE, Perry HM 3rd, Kaiser FE et al. (1993) Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study. J Am Geriatr Soc 41: 149–152

    PubMed  CAS  Google Scholar 

  • Nieschlag E, Simoni M, Gromoll J, Weinbauer GF (1999a) Role ofFSH in regulation of spermatogenesis: clinical aspects. Clin Endocrinol 51: 139–146

    Article  CAS  Google Scholar 

  • Nieschlag E, Buchter D, von Eckardstein S, Abshagen K, Simoni M, Behre HM (1999b) Repeated intramuscular injections of testosterone undecanoate for substitution therapy in hypogonadal men. Clin Endocrinol (Oxf) 51: 757–763

    Article  CAS  Google Scholar 

  • O’Carroll R, Bancroft J (1984) Testosterone therapy for low sexual interest and erectile dysfunction in men: A controlled study. Br J Psychiatry 145: 146–151

    Article  PubMed  Google Scholar 

  • Oh JY, Barrett-Connor E, Wedick NM, Wingard DL (2002) Endogenous sex hormones and the development of type 2 diabetes in older men and women: the Rancho Bernardo study. Diabetes Care 25: 55–60

    Article  PubMed  CAS  Google Scholar 

  • Rolf C, Nieschlag E (2001) Reproductive functions, fertility and genetic risks of ageing men. Exp Clin Endocrinol Diabetes 109: 68–74

    Article  PubMed  CAS  Google Scholar 

  • Rosano GMC, Leonardo F, Pagnotta P et al. (1999) Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 99: 1666–1670

    Article  PubMed  CAS  Google Scholar 

  • Rudman D, Drinka PJ, Wilson CR, Mattson DE, Scherman F, Cuisinier MC, Schultz S (1994) Relations of endogenous anabolic hormones and physical activity to bone mineral density and lean body mass in elderly men. Clin Endocrinol 40: 653–661

    Article  CAS  Google Scholar 

  • Scidman SN, Araujo AB, Roose SP, McKinlay JB (2001) Testosterone level, androgen receptor polymorphism, and depressive symptoms in middle-aged men. Biol Psychiatry 50: 371–376

    Article  Google Scholar 

  • Short KR, Nair KS (1999) Mechanisms of sarcopenia of aging. J Endocrinol Invest 22: 95–105

    PubMed  CAS  Google Scholar 

  • Sih R, Morley JE, Kaiser FE, Perry HM, Patrik P, Ross C (1997) Testosterone replacment in older hypogonadal men: a 12 month randomized controlled trial. J Clin Endocrinol Metab 82: 1661–1667

    Article  PubMed  CAS  Google Scholar 

  • Snyder PJ, Peachey H, Hannoush P et al. (1999) Effect of testosterone treatment on body composition and muscle strength in men over 65 years of age. J Clin Endocrinol Metab 84: 2647–2653

    Article  PubMed  CAS  Google Scholar 

  • Snyder PJ, Peachey H, Berlin JA et al. (2001) Effects of transdermal testosterone treatment on serum lipids and apolipoprotein levels in men more than 65 years of age. Am J Med 111: 255–260

    Article  PubMed  CAS  Google Scholar 

  • Stefansson E, Bek T, Porta M, Larsen N, Kristinsson JK, Agardh E (2000) Screening and prevention of diabetic blindness. Acta Ophthalmol Scand 78: 374–385

    Article  PubMed  CAS  Google Scholar 

  • Stellato RK, Feldman HA, Hamdy O, Horton ES, McKinlay JB (2000) Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care 23: 490–494

    Article  PubMed  CAS  Google Scholar 

  • Swerdloff RS, Wang C, Cunningham G et al. (2000) Long-term pharmacokinetics of transdermal testosterone gel in hypogonadal men. J Clin Endocrinol Metab 85: 4500–4510

    Article  PubMed  CAS  Google Scholar 

  • Tenover JL (1999) Testosterone replacment therapy in older adult men. Int J Androl 22: 300–206

    Article  PubMed  CAS  Google Scholar 

  • Tenover JS (1992) Effects of testosterone supplementation in the aging male. J Clin Endocrinol Metab 75: 1092–1098

    Article  PubMed  CAS  Google Scholar 

  • Thompson PD, Ahlberg AW, Moyna NM et al. (2002) Effect of intravenious testosterone on myocardial ischemia in men with coronary artery disease. Am Heart J 143: 249–255

    Article  PubMed  CAS  Google Scholar 

  • Tripathy D, Shah P, Lakshmy R, Reddy KS (1998) Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res 30: 642–645

    Article  PubMed  CAS  Google Scholar 

  • Urban RJ, Bodenburg YH, Gilkison C, Foxworth-Coggan AR, Wolfe RR, Ferrando (1995) A Testosterone adminsitration to elderly men increases muscel strength and protein synthesis. Am J Physiol 269: E820–E826

    PubMed  CAS  Google Scholar 

  • Veldhuis JD (2000) Recent neuroendocrine facts of male reproductie aging. Exp Geront 35: 1281–1308

    Article  CAS  Google Scholar 

  • Vermeulen A (2002) Ageing, hormones, body composition, metabolic effects. World J Urol 20: 23–27

    Article  PubMed  CAS  Google Scholar 

  • Vermeulen A, Rubens R, Verdonck L (1972) Testosterone secretion and metabolism in male senescence. J Clin Endocrinol Metab 34: 730–735

    Article  PubMed  CAS  Google Scholar 

  • Walker TC (1942) The use of testosterone propionate and estrogenic substance in the treatment of essential hypertension, angina pectoris and peripheral vascular disease. J Clin Endocrinol 2: 560–568

    Article  CAS  Google Scholar 

  • Wang C, Alexander G, Berman N et al. (1996) Testosterone replacement therapy improves mood in hypogonadal men-a clinical research center study. J Clin Endocrinol Metab 81: 3578–3583

    Article  PubMed  CAS  Google Scholar 

  • Wang C, Swedloff RS, Iranmanesh A et al. (2000) Transdermal testosterone gel improves sexual function, mood, muscle strength, and body composition parameters in hypogonadal men. Testosterone Gel Study Group. J Clin Endocrinol Metab 85: 2839–2853

    Article  PubMed  CAS  Google Scholar 

  • Webb CM, Adamson DL, Ziegler D, Collins P (1999a) Effect of acute testosterone administration on myocardial ischemia in men with coronary artery disease. Am J Cardiol 83: 437–439

    Article  PubMed  CAS  Google Scholar 

  • Webb CM, McNeill JG, Hayward CS, Ziegler D, Collins P (1999b) Effect of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 100: 1690–1696

    Article  PubMed  CAS  Google Scholar 

  • Winters SL (1994) Endocrine evaluation of testicular function. Endocrinol Metab Clin North Am 23: 709–724

    PubMed  CAS  Google Scholar 

  • Wu SZ, Weng XZ (1993) Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients. Chin Med J (Eng I) 106: 415–418

    CAS  Google Scholar 

  • Allolio B, Arlt W (2002) DHEA treatment: myth or reality? Trends Endocrinol Metab 13: 288–294

    Article  PubMed  CAS  Google Scholar 

  • Arlt W, Allolio B, Callies F et al. (1999a) Biotransformation of oral dehydroepiandrosterone in elderly men: significant increase in circulating estrogens. J Clin Endocrinol Metab 84: 2170–2176

    Article  PubMed  CAS  Google Scholar 

  • Arlt W, Allolio B, Callies F et al. (1999b) Dehydroepiandrosterone replacement in women with adrenal insufficiency. N Engl J Med 341: 1013–1020

    Article  PubMed  CAS  Google Scholar 

  • Arlt W, Allolio B, Callies F et al. (2001) Dehydroepiandrosterone (DHEA) supplementation in healthy men with an age-related decline of dehydroepiandrosterone secretion. J Clin Endocrinol Metab 86: 4686–4692

    Article  PubMed  CAS  Google Scholar 

  • Baulieu EE, Thomas G, Legrain S et al. (2000) Dehydroepiandrostero-2.3 ne (DHEA), DHEA sulfate, and aging: Contribution of the DHE Age Ostrogene Study to a sociobiomedical issue. Proc Natl Acad Sci USA 97: 4279–4284

    Article  PubMed  CAS  Google Scholar 

  • Bergeron R, de Montigny C, Debonnel G (1996) Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. J Neurosci 16: 1193–1202

    PubMed  CAS  Google Scholar 

  • Berr C, Lafont S, Debuire B, Dartigues JF, Baulieu EE (1996) Relationships of dehydroepiandrosterone sulfate in the elderly with functional, physiological, and mental status, and short-term mortality: a french community-based study. Proc Nat Acad Sci 93: 2605–2610

    Article  Google Scholar 

  • Bloch M, Schmidt PJ, Danaceau MA, Adams LF, Rubinow DR (1999) Dehydroepiandrosterone treatment of mid life dysthymia. Biol Psychiatry 45: 1533–1541

    Article  PubMed  CAS  Google Scholar 

  • Baulieu EE, Thomas G, Legrain S et al. (2000) Dehydroepiandrostero-2.3 ne (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Ostrogene Study to a sociobiomedical issue. Proc Natl Acad Sci USA 97: 4279–4284

    Article  PubMed  CAS  Google Scholar 

  • Bergeron R, de Montigny C, Debonnel G (1996) Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. J Neurosci 16: 1193–1202

    PubMed  CAS  Google Scholar 

  • Berr C, Lafont S, Debuire B, Dartigues JF, Baulieu EE (1996) Relationships of dehydroepiandrosterone sulfate in the elderly with functional, physiological, and mental status, and short-term mortality: a french community-based study. Proc Nat Acad Sci 93: 2605–2610

    Article  Google Scholar 

  • Bloch M, Schmidt PJ, Danaceau MA, Adams LF, Rubinow DR (1999) Dehydroepiandrosterone treatment of mid life dysthymia. Biol Psychiatry 45: 1533–1541

    Article  PubMed  CAS  Google Scholar 

  • Compagnone NA, Mellon SH (1998) Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development. Proc Natl Acad Sci USA 95: 4678–4683

    Article  PubMed  CAS  Google Scholar 

  • Hunt PJ, Gurnell EM, Huppert FA et al. (2000) Improvement in mood and fatigue following DHEA replacement in a randomised double-blind trial in Addison’s disease. J Clin Endocrinol Metab. 85: 4650–4656

    Article  PubMed  CAS  Google Scholar 

  • Liu D, Dillon JS (2002) Dehydroepiandrosterone activates endothelial cell nitric oxide synthase by a specific plasma membrane receptor coupled to G alpha i2,3. J Bioi Chem 277: 21379–21388

    Article  CAS  Google Scholar 

  • Mazat L, Lafont 5, Berr C, Debuire B, Tessier JF, Dartigues JF, Baulieu EE (2001) Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: relationship to gender, subjective health, smoking habits, and 10-year mortality. Proc Natl Acad Sci USA 98: 8145–8150

    Article  PubMed  CAS  Google Scholar 

  • Morales AJ, Nolan JJ, Nelson JE, Yen SS (1994) Effects of replacement dose of dehydroepiandrosterone in men and women of advanced age. J Clin Endocrinol Metab 78: 1360–1367

    Article  PubMed  CAS  Google Scholar 

  • Morales AJ, Haubrich RH, Hwang JY, Asakura H, Yen SS (1998) The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age-advanced men and women. Clin Endocrinol (Oxf) 49: 421–432

    Article  CAS  Google Scholar 

  • Orentreich N, Brind JL, Rizer RL, Vogelman JH (1984) Age changes and sex differences in serum dehydroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 59: 551–555

    Article  PubMed  CAS  Google Scholar 

  • Ravaglia G, Forti P, Maioli F et al. (1996) The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds. J Clin Endocrinol Metab 81: 1173–1178

    Article  PubMed  CAS  Google Scholar 

  • Reiter WJ, Pycha A, Schatzl G et al. (1999). Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study. Urology 53: 590–595

    Article  PubMed  CAS  Google Scholar 

  • Svec F, Porter JR (1998) The actions of exogenous dehydroepiandrosterone in experimental animals and humans. Proc Soc Exp Bioi Med 218: 174–191

    CAS  Google Scholar 

  • Trivedi DP, Khaw KT (2001) Dehydroepiandrosterone sulfate and mortality in elderly men and women. J Clin Endocrinol Metab 86: 4171–4177

    Article  PubMed  CAS  Google Scholar 

  • Wolkowitz OM, Reus VI, Keebler A et al. (1999) Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psych 156: 646–649

    CAS  Google Scholar 

  • Zwain IH, Yen SS (1999) Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain. Endocrinology 140: 3843–3852

    Article  PubMed  CAS  Google Scholar 

  • Barrett-Connor E, Mueller JE, von Muhlen DG, Laughlin GA, Schneider DL, Sartoris DJ (2000) Low levels of estradiol are associated with vertebral fractures in older men, but not women: the Rancho Bernardo Study. J Clin Endocrinol Metab. 85: 219–223

    Article  PubMed  CAS  Google Scholar 

  • Blumenthal RS, Heldman AW, Brinker JA (1997) Acute effects of conjugated estrogens on coronary blood flow response to acetylcholin in men. Am J Cardiol 80: 1021–1024

    Article  PubMed  CAS  Google Scholar 

  • Byers RJ, Hoyland JA, Braidman IP (2001) Osteoporosis in men: a cellular endocrine perspective of an increasingly common clinical problem. J Endocrinol 168: 353–362

    Article  PubMed  CAS  Google Scholar 

  • Carani C, Qin K, Simoni M et al. (1997) Effect of testosterone and estradiol in a men with aromatase deficiency. N Engl J Med 337: 91–95

    Article  PubMed  CAS  Google Scholar 

  • Carani C, Rochira R, Faustini-Fustini M, Balestieri A, Granata ARM (1999) Role of oestrogen in male sexual behaviour: insights from the natural model of aromatase deficiency. Clin Endocrinol 51: 517–524

    Article  CAS  Google Scholar 

  • Collins P, Rosano GMC, Sarrel PM (1995) 17-beta estradiol attenuates acetylcholine-induced coronary arterial vasoconstriction in women but not in men with coronary heart disease. Circulation 92: 24–30

    Article  PubMed  CAS  Google Scholar 

  • Coronary Drug Project Research Group (1970) Initial findings leading to modifications of its research protocol. J Am Med Ass 214: 1303–1313

    Article  Google Scholar 

  • Coronary Drug Project Research Group (1973) The coronary drug project: Findings leading to discontinuation of the 2.5 mg/day estrogen group. J Am Med Ass 226: 652–657

    Article  Google Scholar 

  • Deladoey J, Flock C, Bex M, Yoshimura N, Harada N, Mullis PE (1999) Aromatase deficiency caused by anovel P450,com gene mutation: impact of absent estrogen production on serum gonadotropin concentration in a boy. J Clin Endocrinol Metab 84: 4050–4054

    Article  PubMed  CAS  Google Scholar 

  • Feldman HA (2002) Age trends in the levels of serum testosterone and other hormones in the middle-aged men: longitudinal results from the Massachusetts Male Aging Study. J Clin Endocrinol Metab 87: 589–598

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein JS, O’Dea LSTL, Whitcomb RW, Crowley WF (1991a) Sex steroid control of gonadotropin secretion in the human male. II. Effects of estradiol administration in normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 73: 621–628

    Article  PubMed  CAS  Google Scholar 

  • Finkelstein JS, Whitcomb RW, O’Dea LSTL, Longcope C, Schoenfeld DA, Crowley WF (1991b) Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men. J Clin Endocrinol Metab 73: 609–620

    Article  PubMed  CAS  Google Scholar 

  • Giri S, Thompson PD, Taxel P et al. (1998) Oral estrogen improves serum lipids, homocysteine and fibrinolysis in elderly men. Atherosclerosis 137: 359–366

    Article  PubMed  CAS  Google Scholar 

  • Gooren L (2001) Significance ofoestrogens in male (patho)physiology. In: Gooren L, Lim PHC (eds) The aging male. Meditech, Singapore

    Google Scholar 

  • Gorski RA (1996a) Androgen: effects on the brain: cognitive, sexual, and aggressive behavior — an overview. In: Bhasin S, Gabelnick HL, Spieler JM et al. (eds) Pharmacology, biology, and clinical applications of androgens. John Wiley, New York, pp 157–158

    Google Scholar 

  • Gorski RA (1996b) Androgens and sexual differentiation of the brain. In: Bhasin S, Gabelnick HL, Spieler JM et al. (eds) Pharmacology, biology, and clinical applications of androgens. John Wiley, New York, pp 159–168

    Google Scholar 

  • Gray A, Feldman HA, McKinlay JB, Longcope C (1991) Age, disease, and changing sex hormone levels in middle-aged men: results of the Massachusetts male aging study. J Clin Endocrinol Metab 73: 1016–1025

    Article  PubMed  CAS  Google Scholar 

  • Grohe C, Kahlert S, Lobbert K (1997) Cardiac myocytes and fibroblasts contain functional estrogen receptors. FEBS Letters 416: 107–112

    Article  PubMed  CAS  Google Scholar 

  • Henriksson P, Edhag O, Eriksson A, Johansson SE (1989) Patients at high riskof cardiovascular complications in oestrogen treatment of prostatic cancer. Br J Uro 163: 186–190

    Article  Google Scholar 

  • Herrmann BL, Saller B, Janssen OE et al. (2002) Impact of estrogen replacement therapy in a male with congenital aromatase deficiency caused by a novel mutation in the CYP19 gene. J Clin Endocrinol Metab 87: 5476–5484

    Article  PubMed  CAS  Google Scholar 

  • Hierl T, Borcsok I, Ziegler R, Kasperk C (1999) Osteo-anabolic estrogen therapy in a transsexual man. Dtsch Med Wochenschr 124: 519–522

    Article  PubMed  CAS  Google Scholar 

  • Hiraga T, Shimokawa K, Murase T, Yokoyama M (1993) Reduction of serum lipoprotein(a) by estrogen in men with prostatic cancer. Endocr J 40: 507–513

    Article  PubMed  CAS  Google Scholar 

  • Hodges LK, Tung L, Graham JD, Yan XD, Horwitz KB, Horwitz LD (1998) Heterogeneity of estrogen receptor expression and function in human vascular smooth muscle. Circulation 98: 1–799

    Article  Google Scholar 

  • Hulley S, Grady D, Bush T (1998) Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and estrogen/progestin replacement study (HERS) Research Group. J Am Med Ass 280: 605–613

    Article  CAS  Google Scholar 

  • International Prostate Health Council Study Group (2000) Estrogens and prostatic disease. Prostate 45: 87–100

    Article  Google Scholar 

  • Jakob HR. Wolf L, Budde R, Romalo G, Schweikert HU (1992) Androstendione metabolism in cultured human osteoblast-like cells. J Clin Endocrinol Metab 75: 101–105

    Article  Google Scholar 

  • Jakob F, Siggelkow H, Homann D, Kiihrle J, Adamski J, SchOtze N (1997) Local estradiol metabolism in osteoblast-and osteoclastlike cells. J Steroid Biochem Mol Bio 161: 167–174

    Article  Google Scholar 

  • Jockenhiivel F (2001a) Androgenmangel des alteren Mannes — Was bringt die Testosteron-Substitution? Dtsch Med Wochenschr 126: 247–252

    Article  Google Scholar 

  • Jockenhiivel F (2001b) Was ist gesichert in der Diagnostik und Therapie des partiellen Androgendefizits (PADAM)? Urologe B 41: 325–330

    Article  Google Scholar 

  • Jockenhiivel F, Lerchl A, Allolio B (2001) Hormone gegen das Altern — Miiglichkeiten und Grenzen. Dtsch Arztebl 98: A2041–A2045

    Google Scholar 

  • Lauber ME, Sarasin A, Lichtensteiger W (1997) Sex differences and androgen-dependent regulation of aromatase (CYP19) mRNA expression in the developing and adult rat brain. J Steroid Biochem Mol Bio 161: 359–364

    Article  Google Scholar 

  • Leifke E, Gorenoi V, Wichers C, von zur Mlihlen A, von Buren E, Brabant G (2000) Age-related changes of serum sex hormones, insulin like growth factor-l and sex-hormone binding globulin levels in men: cross sectional data from a healthy male cohort. Clin Endocrinol 53: 689–695

    Article  CAS  Google Scholar 

  • Lindner V, Kim SK, Karas RH, Kuiper GGJM, Gustaffsson JA, Mendelsohn ME (1998) Increased expression of estrogen receptorbeta mRNA in male blood vessels after vascular injury. Circ Res 83: 224–229

    Article  PubMed  CAS  Google Scholar 

  • Kerrigan JR, Rogol AD (1992) The impact of gonadal steroid hormone action on growth hormone secretion during childhood and adolescence. Endocr Rev 13: 281–298

    PubMed  CAS  Google Scholar 

  • Mauras N, Rogol AD, Veldhuis JD (1990) Increased hGH production rate after low-dose estrogen therapy in prepubertal girls with Turner’s syndrome. Pediatr Res 28: 626–630

    Article  PubMed  CAS  Google Scholar 

  • Mauras N (2001) Growth hormone and sex steroids. Interactions in puberty. Endocrinol Metab Clin North Am 30: 529–544

    Article  PubMed  CAS  Google Scholar 

  • Mikkola AK, Ruutu ML, Aro JL, Ranniko SA, Salo JO (1998) Parenteral polyoestradiol phosphate vs orchidectomy in the treatment of advanced prostatic cancer. Efficacy and cardiovascular complications: a 2-year follow-up report of a national, prospective prostatic cancer study. Finnprostate Group. Br J Uro 182: 63–68

    Article  Google Scholar 

  • Morishima A, Grumbach MM, Simpson ER, Fisher C. Qin K (1995) Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens. J Clin Endocrinol Metab 80: 3689–3698

    Article  PubMed  CAS  Google Scholar 

  • O’Donnell L, Robertson KM, Jones ME, Simpson ER (2001) Estrogen and spermatogenesis. Endocr Rev 22: 289–318

    Article  PubMed  Google Scholar 

  • Oettel M, Hubler B, Winkelmann BR (2002) Ober das therapeutische Potential von Estrogenen beim Mann. J Menopause 2: 37–45

    Google Scholar 

  • Oliver MF, Boyd GS (1961) Influence of reduction of serum lipids on prognosis of coronary heart disease. Lancet 2: 499–505

    Article  PubMed  CAS  Google Scholar 

  • Ongphiphadhanakul B, Thamprajamchit S, Chanprasertyothin S, Chailurkit L, Rajatanavin R (2002) Effect of estrogen replacement on insulin sensitivity, serum lipid and bone resorption marker in hypogonadal males. Maturitas 42: 85–89

    Article  PubMed  CAS  Google Scholar 

  • Phillips GB, Castelli WP, Abbott RD, McNamara PM (1983) Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort. Am J Med 74: 863–869

    Article  PubMed  CAS  Google Scholar 

  • Phillips GB (1993) Relationship of serum sex hormones to coronary heart disease. Steroids 58: 286–290

    Article  PubMed  CAS  Google Scholar 

  • Phillips GB, Pinkernell BH, Jing TY (1996) The association of hyperestrogenemia with coronary thrombosis in men. Arterioscler Thromb 16: 1383–1387

    Article  CAS  Google Scholar 

  • Reis SE, Holubkov R, Zell KA (1998a) Conjugated estrogens acutely abolish abnormal cold-induced coronary vasoconstriction in male cardiac allografts. Circulation 97: 23–25

    Article  PubMed  CAS  Google Scholar 

  • Reis SE, Holubkov R, Zell KA (1998b) Estrogen acutely abolishes abnormal cold-induced coronary constriction in men. Chest 114: 1556–1561

    Article  PubMed  CAS  Google Scholar 

  • Reutrakul S, Ongphiphadhanakul B, Piaseu N, Krittiyawong S, Chanprasertyothin S, Bunnag P, Rajatanavin R (1998) The effects of oestrogen exposure on bone mass in male to female transsexuals. Clin Endocrinol (Oxf) 49: 811–814

    Article  CAS  Google Scholar 

  • Rubanyi GM, Freay AD, Kauser K (1997) Vascular estrogen receptors and endothelium-derived nitric oxide production in the mouse aorta. J Clin Invest 99: 2429–2437

    Article  PubMed  CAS  Google Scholar 

  • Schoch HK (1969) The U.S. veterans administration cardiology druglipid study: an interim report. In: Holmes WL, Carlson LA, Paoletti R (eds) Drugs affecting lipid metabolism. Plenum, New York, pp 405–420

    Chapter  Google Scholar 

  • Signoretti S, Loda M (2001) Estrogen receptor b in prostate cancer: brake pedal or accelerator? Am J Pathol 159: 13–16

    Article  PubMed  CAS  Google Scholar 

  • Smith EP, Boyd J, Frank GR, Takahashi H et al. (1994) Estrogen resistence caused by a mutation in the estrogen receptor gene in a man. N Engl J Med 331: 1056–1061

    Article  PubMed  CAS  Google Scholar 

  • Sudhir K, Chou TM, Messina LM (1997) Endothelial dysfunction in a man with disruptive mutation in oestrogen-receptor gene. Lancet 349: 1146–1147

    Article  PubMed  CAS  Google Scholar 

  • Taxel P, Kennedy DG, Fall PM, Willard AK, Clive JM, Raisz LG (2001) The effect of aromatase inhibition on sex steroids, gonadotropins, and markers of bone turnover in older men. J Clin Endocrinol Metab 86: 2869–2874

    Article  PubMed  CAS  Google Scholar 

  • Ulloa-Aguirre A, Blizzard RM, Garcia-Rubi E et al. (1990) Testosterone and oxandrolone, a nonaromatizable androgen, specifically amplify the mass and rate of growth hormone (GH) secreted per burst without altering GH secretory burst duration or frequency or the GH half-life. J Clin Endocrinol Metab 71: 846–854

    Article  PubMed  CAS  Google Scholar 

  • Ushiyama T, Ueyama H, Inoue K, Ohkubo I, Hukuda S (1999) Expression of genes for estrogen receptors alpha and beta in human articular chondrocytes. Osteoarthritis Cartilage 7: 560–566

    Article  PubMed  CAS  Google Scholar 

  • Van den Beld A, de Jong FH, Grobbee DE, Pols HAP, Lamberts SJW (2000) Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men. J Clin Endocrinol Metab 85: 3276–3282

    Article  PubMed  Google Scholar 

  • Van Kesteren PJM, Asscheman H, Megens JAJ, Gooren LJG (1997) Mortality and morbidity in transsexual subjects treated with cross-sex hormones. Clin Endocrinol 47: 337–342

    Article  Google Scholar 

  • Vermeulen A, Kaufman JM, Goemaere S, van Pottelberg I (2002) Estradiol in elderly men. Aging Male 5: 98–102

    PubMed  CAS  Google Scholar 

  • Abdu TA, Neary R, Elhadd TA, Akber M, Clayton RN (2001) Coronary risk in growth hormone deficient hypopituitary adults: increased predicted risk is due largely to lipid profile abnormalities. Clin Endocrinol 55: 209–216

    Article  CAS  Google Scholar 

  • Bates AS, Bullivant B (1997) Increased mortality in hypopituitarism is not due to an increased in vascular mortality. J Endocrinol 152 (Suppl): OC9

    Article  CAS  Google Scholar 

  • Bates AS, Van Hoff W, Jones PJ, Clayton RN (1996) The effect of hypopituitarism on life expectancy. J Clin Endocrinol Metab 81: 1169–1172

    Article  PubMed  CAS  Google Scholar 

  • Berelowitz M, Szabo M, Frohman LA, Firestone S, Chu L, Hintz RL (1981) Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science 212: 1279–1281

    Article  PubMed  CAS  Google Scholar 

  • Bulow B, Hagmar L, Mikoczy Z, Nordstrom CH, Erfurth EM (1997) Increased cerebrovascular mortality in patients with hypopituitarism. Clin Endocrinol 46: 75–81

    Article  CAS  Google Scholar 

  • Colao A, di Somma C, Cuocolo A et al. (2001) Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. J Clin Endocrinol Metab 86: 1874–1881

    Article  PubMed  CAS  Google Scholar 

  • Colao A, di Somma C, Pivonello R et al. (2002) The cardiovascular risk of adult GH deficiency (GHD) improved after GH replacement and worsened in untreated GHD: a 12-month prospective study. J Clin Endocrinol Metab 87: 1088–1093

    Article  PubMed  CAS  Google Scholar 

  • Cook DM (2002) Shouldn’t adults with growth hormone deficiency be offered growth hormone replacement therapy? Ann Intern Med. 137: 197–201

    PubMed  Google Scholar 

  • Cutfield WS, Wilton P, Bennmarker H, Albertson-Wikland K, Chatelain P, Ranke MB, Price DA (2000) Incidence of diabetes mellitus and impaired glucose tolerance in children and adolescents receiving growth-hormone treatment. Lancet 355: 610–613

    Article  PubMed  CAS  Google Scholar 

  • De Boer H, Blok GJ, Van der Veen EA (1995) Clinical aspects of growth hormone deficiency in adults. Endocr Rev 16: 63–86

    Article  PubMed  Google Scholar 

  • D’Ercole AJ, Applewhite GT, Underwood LE (1980) Evidence that somatomedin is synthesized by mUltiple tissues in the fetus. Dev Bioi Mar 75: 315–328

    Article  Google Scholar 

  • Green H, Morikawa M, Nixon T (1985) A dual effector theory of growth-hormone action. Differentiation 29: 195–198

    Article  PubMed  CAS  Google Scholar 

  • Growth Hormone Research Society (1998) Consensus guidelines for the diagnosis and treatment of adults with growth hormone deficiency: Summary statement of the Growth Hormone Research Society workshop on adult growth hormone deficiency. J Clin Endocrinol Metab 83: 379–381

    Article  Google Scholar 

  • Growth Hormone Research Society (2001) Critical evaluation of the safety of recombinant human growth hormone administration: statement from the Growth Hormone Research Society. J Clin Endocrinol Metab 86: 1868–1870

    Article  Google Scholar 

  • Hansen PS, Kassem M, Brixen K, Klausen IC, Mosekilde L, Faergeman O (1995) Effect of short-term treatment with recombinant human growth hormone on lipids and lipoproteins in women and men without growth hormone disturbances. Metabolism 44: 725–729

    Article  PubMed  CAS  Google Scholar 

  • Jockenhovel F, Lerchl A, Allolio B (2001) Hormone gegen das Altern — Moglichkeiten und Grenzen. Dtsch Arztebl 98: A2041–A2045

    Google Scholar 

  • Johannsson G, Marin P, Lonn L et al. (1997) Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. J Clin Endocrinol Metab 82: 727–734

    Article  PubMed  CAS  Google Scholar 

  • Jorgensen JO, Pedersen SA, Thuesen L et al. (1989) Beneficial effects of growth hormone treatment in GH-deficient adults. Lancet 1 (8649): 1221–1225

    Article  PubMed  CAS  Google Scholar 

  • Kann P, Piepkorn B, Schehler B, Andreas J, Lotz J, Prellwitz W, Beyer J (1998) Effect of long-term treatment with GH on bone metabolism, bone mineral density and bone elasticity in GH-deficient adults. Clin Endocrinol (Oxf) 48: 561–568

    Article  CAS  Google Scholar 

  • Kozakowski J, Papierska L, Krassowski J, Zgliczynski S (1998) The effect of growth hormone replacement therapy on markers of bone formation and bone mineral density in elderly men. Pol Arch Med Wewn 100: 306–312

    PubMed  CAS  Google Scholar 

  • Le Roith D, Bondy C, Yakar S, Liu JL, Butler A (2001) The somatomedin hypothesis: 2001. Endocr Rev 22: 53–74

    Article  PubMed  Google Scholar 

  • Oscarsson J, Ottosson M, Wiklund O, Marin P, Vikman-Adolfsson K, Bjorntorp P, Eden S (1994) Low dose continuously infused growth hormone results in increased lipoprotein(a) and decreased low density lipoprotein cholesterol concentrations in middle-aged men. Clin Endocrinol 41: 109–116

    Article  CAS  Google Scholar 

  • Rosen T, Wilhelmsen L, Landin-Wilhelmsen K, Lappas G, Bengtsson B (1997) Increased fracture frequency in adult patients with hypopituitarism and GH deficiency. Eur J Endocrinol 137: 240–245

    Article  PubMed  CAS  Google Scholar 

  • Rudling M, Norstedt G, Olivercrona H, Reihner E, Gustafsson J-A, Angelin B (1992) Importance of growth hormone for the induction of hepatic low denstiy lipoprotein receptors. Proc Natl Acad Sci USA 89: 6983–6987

    Article  PubMed  CAS  Google Scholar 

  • Rudman D, Feller AG, Nagraj HS et al. (1990) Effects of human growth hormone in men over 60 years old. N Engl J Med 323: 1–6

    Article  PubMed  CAS  Google Scholar 

  • Rudman D, Feller AG, Cohn L, Shetty KR, Rudman IW, Draper MW (1991) Effects of human growth hormone on body composition in elderly men. Horm Res 36 (Suppl1): 73–81

    Article  PubMed  Google Scholar 

  • Salomon F, Cuneo RC, Hesp R, Sonksen PH (1989) The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321: 1797–1803

    Article  PubMed  CAS  Google Scholar 

  • Shi R, Berkel HJ, Yu H (2001) Insulin-like growth factor-I and prostate cancer: a meta-analysis. Br J Cancer 85: 991–996

    Article  PubMed  CAS  Google Scholar 

  • Span JP, Pieters GF, Sweep FG, Hermus AR, Smals AG (2001) Gender differences in rhGH-induced changes in body composition in GH-deficient adults. J Clin Endocrinol Metab 86: 4161–4165

    Article  PubMed  CAS  Google Scholar 

  • Strasburger CJ, Jaursch-Hancke C, Kann PH, Klingmuller D, Plockinger U, Petersenn S, Quabbe H-J (2002) Milebrauchlicher Einsatz von humanem Wachstumshormon in der Anti-Aging-Medizin. Dtsch Arztebl 99: A3177–3180

    Google Scholar 

  • Svensson J, Bengtsson BA, Taskinen MR, Wiklund O, Johannsson G (2000) A nine-month, placebo-controlled study of the effects of growth hormone treatment on lipoproteins and LDL size in abdominally obese men. Growth Horm IGF Res 10: 118–126

    Article  PubMed  CAS  Google Scholar 

  • Taaffe DR, Jin IH, Vu TH, Hoffman AR, Marcus R (1996) Lack of effect of recombinant human growth hormone (GH) on muscle morphology and GH-insulin-like growth factor expression in resistancetrained elderly men. J Clin Endocrinol Metab 81: 421–425

    Article  PubMed  CAS  Google Scholar 

  • Tomlinson JW, Holden N, Hills RK et al. (2001) Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet 357 (9254): 425–431

    Article  PubMed  CAS  Google Scholar 

  • Wu Y, Yakar S, Zhao L, Hennighausen L, Leroith D (2002) Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 62: 1030–1035

    PubMed  CAS  Google Scholar 

  • Woster C, Abs R, Bengtsson BA et al. (2001) The influence of growth hormone deficiency, growth hormone replacement therapy, and other aspects of hypopituitarism on fracture rate and bone mineral density. J Bone Miner Res 16: 398–405

    Article  Google Scholar 

  • Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, Le Roith D (1999) Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96: 7324–7329

    Article  PubMed  CAS  Google Scholar 

  • Biesalski HK (2002) Free radical theory of aging. Curr Opin Clin Nutr Metab Care 5: 5–10

    Article  PubMed  CAS  Google Scholar 

  • Cardinali DP, Brusco LI, Liberczuk C, Furio AM (2002) The use of melatonin in Alzheimer’s disease. Neuroendocrinol Lett 23 (SuppI1): 20–23

    PubMed  CAS  Google Scholar 

  • Chase JE, Gidal BE (1997) Melatonin: therapeutic use in sleep disorders. Ann Pharmacother 31: 1218–1226

    PubMed  CAS  Google Scholar 

  • Fauteck JD (2001) Melatonin: gibt es eine Rationale fur den klinischen Einsatz dieses Hormons in der Schlaftherapie? Z Arztl Fortbild Qualitatssich 95: 39–43

    PubMed  CAS  Google Scholar 

  • Grundman M, Delaney P (2002) Antioxidant strategies for Alzheimer’s disease. Proc Nutr Soc 61: 191–202

    Article  PubMed  CAS  Google Scholar 

  • Guardiola-Lemaitre B (1997) Toxicology of melatonin. J Bioi Rhythms 12:697–706

    Article  CAS  Google Scholar 

  • Hermann R, Podhajsky S, Jungnickel S, Lerchl A (2002) Potentiation of anti proliferative effects of tamoxifen and ethanol on mouse hepatoma cells by melatonin: possible involvement of mitogenactivated protein kinase and induction of apoptosis. J Pineal Res 33: 8–13

    Article  PubMed  CAS  Google Scholar 

  • Herxheimer A, Petrie KJ (2002) Melatonin for the prevention and treatment of jet lag. Cochrane Database Syst Rev: CD001520

    Google Scholar 

  • Leibenluft E, Feldman-Naim S, Turner EH, Schwartz PJ, Wehr TA (1996) Salivary and plasma measures of dim light melatonin onset (DLMO) in patients with rapid cycling bipolar disorder. Bioi Psychiatry 40: 731–735

    Article  CAS  Google Scholar 

  • Lerchl A, Partsch CJ (1994) Reliable analysis of individual human melatonin profiles by complex cosinor analysis. J Pineal Res 16: 85–90

    Article  PubMed  CAS  Google Scholar 

  • Lerchl A, Partsch CJ, Nieschlag E (1995) Circadian and ultradian variations of pituitary and pineal hormones in normal men: evidence for a link between melatonin, gonadotropin, and prolactin secretion. J Pineal Res 18: 41–48

    Article  PubMed  CAS  Google Scholar 

  • Lerner AB, Case JD, Takahashi Y, Lee TH, Mori W (1958) Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc 80: 2587

    Article  CAS  Google Scholar 

  • Luboshitzky R, Lavie P (1999) Melatonin and sex hormone interrelationships — a review. J Pediatr Endocrinol Metab 12: 355–362

    Article  PubMed  CAS  Google Scholar 

  • Luboshitzky R, Levi M, Shen-Orr Z, Blumenfeld Z, Herer P, Lavie P (2000a) Long-term melatonin administration does not alter pituitary-gonadal hormone secretion in normal men. Hum Reprod 15: 60–65

    Article  PubMed  CAS  Google Scholar 

  • Luboshitzky R, Shen-Orr Z, Ishai A, Lavie P (2000b) Melatonin hypersecretion in male patients with adult-onset idiopathic hypogonadotropic hypogonadism. Exp Clin Endocrinol Diabetes 108: 142–145

    Article  PubMed  CAS  Google Scholar 

  • Menaker M (2003) Circadian photoreception. Science 299: 213–214

    Article  PubMed  CAS  Google Scholar 

  • Noonan CW, Reif JS, Burch JB, Ichinose TY, Yost MG, Magnusson K (2002) Relationship between amyloid beta protein and melatonin metabolite in a study of electric utility workers. J Occup Environ Med 44: 769–775

    PubMed  CAS  Google Scholar 

  • Poeggeler B, Reiter RJ, Tan DX, Chen LD, Manchester LC (1993) Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesis. J Pineal Res 14: 151–168

    Article  PubMed  CAS  Google Scholar 

  • Redman JR (1997) Circadian entrainment and phase shifting in mammals with melatonin. J Bioi Rhythms 12: 581–587

    Article  CAS  Google Scholar 

  • Reiter RJ, Tan DX, Osuna C, Gitto E (2000) Actions of melatonin in the reduction of oxidative stress. A review. J Biomed Sci 7: 444–458

    Article  PubMed  CAS  Google Scholar 

  • Rohr UD, Herold J (2002) Melatonin deficiencies in women. Maturitas 41 (Suppl1): S85–104

    Article  PubMed  CAS  Google Scholar 

  • Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P (2002) Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 17: 1120–1127

    Article  PubMed  Google Scholar 

  • Tan DX, Manchester LC, Reiter RJ, Qi WB, Karbownik M, Calvo JR (2000) Significance of melatonin in antioxidative defense system: reactions and products. Bioi Signals Recept 9: 137–159

    Article  CAS  Google Scholar 

  • Thomas L, Purvis CC, Drew JE, Abramovich DR, Williams LM (2002) Melatonin receptors in human fetal brain: 2-[(125)lliodomelatonin binding and MTl gene expression. J Pineal Res 33: 218–224

    Article  PubMed  Google Scholar 

  • Waldhauser F, Kovacs J, Reiter E (1998) Age-related changes in melatonin levels in humans and its potential consequences for sleep disorders. Exp Gerontol 33: 759–772

    Article  PubMed  CAS  Google Scholar 

  • Zhdanova IV, Wurtman RJ (1997) Efficacy of melatonin as a sleep-promoting agent. J Bioi Rhythms 12: 644–650

    Article  CAS  Google Scholar 

  • Zhdanova IV, Lynch HJ, Wurtman RJ (1997) Melatonin: a sleep-promoting hormone. Sleep 20: 899–907

    PubMed  CAS  Google Scholar 

  • Zisapel N (1999) The use of melatonin for the treatment of insomnia. Bioi Signals Recept 8: 84–89

    Article  CAS  Google Scholar 

  • Zucconi M, Bruni O (2001) Sleep disorders in children with neurologic diseases. Semin Pediatr Neurol 8: 258–275

    Article  PubMed  CAS  Google Scholar 

  • Canaris GJ, Manowitz MR, Mayor G, Ridgway EC (2000) The Colorado thyreoid disease prevalence study. Arch Intern Med 160: 526–534

    Article  PubMed  CAS  Google Scholar 

  • Derwahl M, Studer H (2001) Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. Exp Clin Endocrinol Diabetes 109: 250–260

    Article  PubMed  CAS  Google Scholar 

  • Dumont JE, Maenhaut C, Baptist M, Roger PP (1991) Growth factors controlling the thyroid gland. Baillieres Clinical Endocrinol Metab 5: 727–754

    Article  CAS  Google Scholar 

  • Gartner R, Dugrillon A (1998) Vom Jodmangel zur Struma. Internist 39:566–573

    Article  PubMed  CAS  Google Scholar 

  • Lee MS, Kim SY, Lee MC et al. (1990) Negative correlation between the change in bone mineral density and serum osteocalcin in patients with hyperthyreodism. J Clin Endocrinol Metab 70: 766–770

    Article  PubMed  CAS  Google Scholar 

  • Roberts AB, Heine UI, Flanders KC, Sporn MB (1990) Transforming growth factor-b: Major role in regulation of extracellular matrix. Ann NY Acad Sci 580: 225–232

    Article  PubMed  CAS  Google Scholar 

  • Sawin CT, Bigos ST, Land S, Bacharach P (1985a) The aging thyreoid. Relationship between elevated serum thyrotropin level and thyreoid antibodies in elderly patients. Am J Med 79: 591–594

    Article  PubMed  CAS  Google Scholar 

  • Sawin CT, Castelli WP, Hershman JM et al. (1985b) The aging thyreoid. Thyreoid deficiency in the Framingham Study. Arch Intern Med 145: 1386–1388

    Article  PubMed  CAS  Google Scholar 

  • Sawin CT, Geller A, Wolf PA et al. (1994) Low serum thyreotropin concentrations as a risk factor for atrial fibrillation in older persons. N Engl J Med 331: 1249–1252

    Article  PubMed  CAS  Google Scholar 

  • Shen DHY, Kloos RT, Mazzaferri EL, Jhiang SM (2001) Sodium iodide symporter in health and disease. Thyroid 11: 415–425

    Article  PubMed  CAS  Google Scholar 

  • Siegel RD, Lee SL (1998) Toxic nodular goiter: toxic adenoma and toxic multinodular goiter. Endocrinol Metab Clin North Am 27: 151–168

    Article  PubMed  CAS  Google Scholar 

  • American Society for Reproductive Medicine (1998) Guidelines for therapeutic donor insemination: sperm. Fertil Steril 70 (SuppI3): 1S–3S

    Google Scholar 

  • Baccarelli A, Morpurgo PS, Corsi A et al. (2001) Activin A serum levels and aging of the pituitary-gonadal axis: a cross-sectional study in middle-aged and elderly healthy subjects. Exp Gerontol 36: 1403–1412

    Article  PubMed  CAS  Google Scholar 

  • Bertram L, Busch R, Spiegl M, Lautenschlager NT, Muller U, Kurz A (1998) Paternal age is a risk factor for Alzheimer disease in the absence of a major gene. Neurogenetics 1: 277–280

    Article  PubMed  CAS  Google Scholar 

  • Bordson BL, Leonardo VS (1991) The appropriate upper age limit for semen donors: a review of the genetic effects of paternal age. Fertil Steril 56: 397–401

    PubMed  CAS  Google Scholar 

  • British Andrology Society (1999) British Andrology Society guidelines for the screening of semen donors for donor insemination. Hum Reprod 14: 1823–1826

    Article  PubMed  CAS  Google Scholar 

  • Brown AS, Schaefer CA, Wyatt RJ et al. (2002) Paternal age and risk of schizophrenia in adult offspring. Am J Psychiatry 159: 1528–1533

    Article  PubMed  Google Scholar 

  • Bundesarztekammer (1998) Richtlinien zur pranatalen Diagnostik von Krankheiten und Krankheitsdispositionen. Dtsch Arztebl 95: A3236–3242

    Google Scholar 

  • De La Rochebrochard E, Thonneau P (2002) Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study. Hum Reprod 17: 1649–1656

    Article  PubMed  Google Scholar 

  • Dunson DB, Colombo B, Baird D (2002) Changes with age in the level and duration of fertility in the menstrual cycle. Hum Reprod 17: 1399–1403

    Article  PubMed  Google Scholar 

  • Erickson JD, Bjerkedal T (1981) Down syndrome associated with fathers’ age in Norway. J Med Genet 18: 22–28

    Article  PubMed  CAS  Google Scholar 

  • Ewing CK, Loffredo CA, Beaty TH (1997) Paternal risk factors for isolated membranous ventricular septal defects. Am J Med Genet 71: 42–46

    Article  PubMed  CAS  Google Scholar 

  • Ford WCL, North K, Taylor H, Farrow A, Hull MGR, Golding J (2000) Increasing paternal age is associated with delayed conception in a large population of fertile couples: evidence for declining fecundity in older men. Hum Reprod 15: 1703–1708

    Article  PubMed  CAS  Google Scholar 

  • Friedman JM (1981) Genetic disease in the offspring of older fathers. Obstet Gynecol 57: 745–749

    PubMed  CAS  Google Scholar 

  • Gallardo E, SimOn C, Levy M (1996) Effect of age on sperm fertility potential: oocyte donation as a model. Fertil Steril 66: 260–264

    PubMed  CAS  Google Scholar 

  • Gavrilov LA, Gavrilova NS, Kroutko VN et al. (1997) Mutation load and human longevity. Mutat Res 377: 61–62

    PubMed  CAS  Google Scholar 

  • Glaser RL, Jiang W et al. (2000) Paternal origin of FGFR2 mutations in sporadic cases of Crouzon syndrome and Pfeiffer syndrome. Am J Hum Genet 66: 768–777

    Article  PubMed  CAS  Google Scholar 

  • Haidl G, Jung A, Schill WB (1996) Ageing and sperm function. Hum Reprod 11: 558–560

    Article  PubMed  CAS  Google Scholar 

  • Handelsman DJ, Staraj S (1985) Testicular size: the effects of aging, malnutrition, and illness. J Androl 6: 144–151

    PubMed  CAS  Google Scholar 

  • Harlap S, Paltiel O, Deutsch L et al. (2002) Paternal age and preeclampsia. Epidemiology 13: 660–667

    Article  PubMed  Google Scholar 

  • Hassold T, Hunt P (2001) To err (meiotically) is human: the genesis of human aneuploidy. Nat Rev Genet 2: 280–291

    Article  PubMed  CAS  Google Scholar 

  • Hook EB, Regal RR (1984) A search for paternal-age effect upon cases of 47,+21 in which the extra chromosome is of paternal origin. Am J Hum Genet 36: 413–421

    PubMed  CAS  Google Scholar 

  • Johnson L, Grumbles JS, Bagheri A, Petty CS (1990) Increased germ cell degeneration during postprophase of meiosis is related to increased serum follicle-stimulating hormone concentrations and reduced daily sperm production in aged men. Bioi Reprod 42: 281–287

    Article  CAS  Google Scholar 

  • Jung A, Schuppe HC, Schill WB (2002) Comparison of semen quality in older and younger men attending an andrology clinic. Andrologia 34: 116–122

    Article  PubMed  CAS  Google Scholar 

  • Kazaura MR, Lie RT (2002) Down’s syndrome and paternal age in Norway. Paediatr Perinat Epidemiol 16: 314–319

    Article  PubMed  Google Scholar 

  • Kidd SA, Eskkenazi B, Wyrobek AJ (2001) Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril 75: 237–248

    Article  PubMed  CAS  Google Scholar 

  • Kluwe L, Mautner V, Parry DM, Jacoby LB, Baser M, Gusella J, Davis K, Stavrou D, MacCollin M (2000) The parental origin of new mutations in neurofibromatosis 2. Neurogenetics 3: 17–24

    Article  PubMed  CAS  Google Scholar 

  • Lian ZH, Zack MM, Erickson JD (1986) Paternal age and the occurrence of birth defects. Am J Hum Genet 39: 648–660

    PubMed  CAS  Google Scholar 

  • Lorda-Sanchez I, Binkert F, Maechler M, Robinson WP, Schinzel AA (1992) Reduced recombination and paternal age effect in Klinefelter syndrome. Hum Genet 89: 524–530

    Article  PubMed  CAS  Google Scholar 

  • Luetjens CM, Rolf C, Gassner P, Werny JE, Nieschlag E (2002) Sperm aneuploidy rates in younger and older men. Hum Reprod 17: 1826–1832

    Article  PubMed  CAS  Google Scholar 

  • MacDonald M, Hassold T, Harvey J, Wang LH, Morton NE, Jacobs P (1994) The origin of 47,XXY and 47,XXX aneuploidy: heterogeneous mechanisms and role of aberrant recombination. Hum Mol Genet 3: 1365–1371

    Article  PubMed  CAS  Google Scholar 

  • Malaspina D, Corcoran C, Fahim C et al. (2002) Paternal age and sporadic schizophrenia: evidence for de novo mutations. Am J Med Genet 114:299–303

    Article  PubMed  Google Scholar 

  • Mathieu C, Ecochard R, Bied V, Lornage J, Czyba JC (1995) Cumulative conception rate following intrauterine artificial insemination with husband’s spermatozoa: influence of husband’s age. Hum Reprod 10: 1090–1097

    PubMed  CAS  Google Scholar 

  • Mcintosh GC, Olshan AF, Baird PA (1995) Paternal age and the risk of birth defects in offspring. Epidemiology 6: 282–288

    Article  PubMed  CAS  Google Scholar 

  • Nieschlag E, Lammers U, Freischem CW, Langer K, Wickings EJ (1982) Reproductive functions in young fathers and grandfathers. J Clin Endocrinol Metab 55: 676–681

    Article  PubMed  CAS  Google Scholar 

  • Olshan AF, Schnitzer PG, Baird PA (1994) Paternal age and the risk of congenital heart defects. Teratology 50: 80–84

    Article  PubMed  CAS  Google Scholar 

  • Penrose LR (1955) Parental age and mutation. Lancet 269: 312–313

    Article  PubMed  CAS  Google Scholar 

  • Risch N, Reich EW, Wishnick MM, McCarthy JG (1987) Spontaneous mutation and parental age in humans. Am J Hum Genet 41: 218–248

    PubMed  CAS  Google Scholar 

  • Rolf C, Behre HM, Nieschlag E (1996) Reproductive parameters of older compared to younger men of infertile couples. Int J Androl 19: 135–142

    Article  PubMed  CAS  Google Scholar 

  • Rolf C, Kenkel S, Nieschlag E (2002) Age-related disease pattern in infertile men: increasing incidence of infections in older patients. Andrologia 34: 209–217

    Article  PubMed  CAS  Google Scholar 

  • Seymour FI, Duffy C, Koerner A (1935) A case of authenticated fertility in a man, aged 94. JAMA 105: 1423–1424

    Article  Google Scholar 

  • Spandorfer SD, Avrech OM, Colombero LT, Palermo GD, Rosenwaks Z (1998) Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection. Hum Reprod 13: 334–338

    Article  PubMed  CAS  Google Scholar 

  • Syed V, Hecht NB (2002) Disruption of germ cell-Sertoli cell interactions leads to spermatogenic defects. Mol Cell Endocrinol 186: 155–157

    Article  PubMed  CAS  Google Scholar 

  • Tiemann-Boege I, Navidi W, Grewal R, Cohn D, Eskenazi B, Wyrobek AJ, Arnheim N (2002) The observed human sperm mutation frequency cannot explain the achondroplasia paternal age effect.

    Google Scholar 

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Schubert, M. et al. (2004). Hormonwirkungen und Hormontherapie. In: Männersprechstunde. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18705-6_2

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