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Pränatale Diagnostik: Molekularbiologische Methoden

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Die Geburtshilfe

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Zusammenfassung

In den letzten Jahren hat durch den raschen und gezielten Einsatz von innovativen molekularbiologischen Methoden wie der Polymerasekettenreaktion (PCR) und der Fluoresenz-in-situ-Hybridisierung (FISH) ein rasanter Fortschritt in der Pränataldiagnostik stattgefunden. Mittels dieser Methoden ist es möglich geworden, Chromosomenstörungen und monogene Erkrankungen auch in einzelnen Zellen zu eruieren, eine Prozedur, die eine Präimplantationsdiagnostik ermöglicht. Auch sind große Fortschritte in der nichtinvasiven und somit risikofreien Diagnostik von fetalen genetischen Merkmalen erzielt worden, vor allem durch die PCR-Untersuchung von zellfreier fetaler DNS im mütterlichen Plasma, womit jetzt die ersten kommerziellen klinischen Tests für das Erfassen des fetalen Rhesusstatus in Schwangerschaften mit einer Rhesuskonstellation angeboten werden.

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Authors
  1. S. Hahn
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  2. W. Holzgreve
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Editor information

Editors and Affiliations

  1. Ehem. Direktor der Universitätsfrauenklinik am Inselspital Bern, Ahornweg 4, 3122, Kehrsatz, Schweiz

    Henning Schneider

  2. Abteilung für Geburtshilfe und Gynäkologie, Universitätsklinik für Frauenheilkunde, Währinger Gürtel 18-20, 1090, Wien, österreich

    Peter Husslein

  3. Abteilung für Perinatalmedizin Frauenklinik und Poliklinik des Klinikums rechts der Isar, Universität der Technischen Universität München, Ismaninger Straße 22, 81675, München

    Karl-Theo M. Schneider

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© 2004 Springer-Verlag Berlin Heidelberg

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Hahn, S., Holzgreve, W. (2004). Pränatale Diagnostik: Molekularbiologische Methoden. In: Schneider, H., Husslein, P., Schneider, KT.M. (eds) Die Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18574-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-18574-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-30522-4

  • Online ISBN: 978-3-642-18574-8

  • eBook Packages: Springer Book Archive

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