Zusammenfassung
Der Typ-1-Diabetes ist Folge einer selektiven Zerstörung der insulinproduzierenden Zellen des endokrinen Pankreas. Die Ätiologie der Erkrankung ist noch nicht geklärt, wahrscheinlich handelt es sich um eine Immunerkrankung mit genetischem Hintergrund. Diese Annahme steht auf vier Grundpfeilern:
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mononukleäre Infiltration der Pankreasinseln (Insulitis) bei neu entdecktem Typ-1-Diabetes,
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Nachweis inselzellspezifischer humoraler und zellulärer Autoimmunreaktionen,
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spezifische Assoziation mit Genen des Immunsystems,
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Veränderung des natürlichen Verlaufs der Erkrankung durch Behandlung mit Immunsuppressiva (Cyclosporin A).
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Scherbaum, W.A., Kolb, H. (2004). Diabetes mellitus Typ 1: Ätiologie und Pathogenese. In: Waldhäusl, W.K., Gries, F.A., Scherbaum, W.A. (eds) Diabetes in der Praxis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18571-7_3
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DOI: https://doi.org/10.1007/978-3-642-18571-7_3
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