Skip to main content

Rubber Chemicals

  • Chapter
  • 385 Accesses

Abstract

Rubber-based products permeate our lives, forming part of the many materials used for personal, domestic and industrial purposes. Rubber may be natural, synthetic or a mixture of the two. Since the vast majority of rubberized materials are unlabeled, it is difficult to determine whether a product contains natural or synthetic rubber. The overlap between “rubber” and “plastic” further complicates the matter, since plastics contain many of the same catalysts, stabilizers, antioxidants and pigments/dyes present in rubber products. (1981) listed a number of naphthylamines, substituted para-phenylenediamines, alkylphenols, and hydro-quinone derivatives that are utilized in manufaeturing both rubber and plastic. Although completely cured plastics rarely sensitize, fully cured rubber products produce Allergic reactions because the allergens in rubber can leach out or “bloom” over time.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams RM (1974) Mercaptobenzothiazole in veterinary medications. Contact Dermatitis Newsletter 16:514

    Google Scholar 

  • Adams RM (1983) Occupational skin disease. New York: Grune-Stratton, pp 1–26, 289–312

    Google Scholar 

  • Alfonzo C (1979) Allergic contact dermatitis to isopropylaminodiphenylamine (IPPD). Contact Dermatitis 5:145–147

    Article  PubMed  CAS  Google Scholar 

  • Ancona A, Monroy F, Fernandez-Diez J (1982) Occupational dermatitis from IPPD in tyres. Contact Dermatitis 8:91–94

    Article  PubMed  CAS  Google Scholar 

  • Andersen KE (1983) Diethylthiourea contact dermatitis from an acidic detergent. Contact Dermatitis 9:146

    Article  PubMed  CAS  Google Scholar 

  • Blancas-Espinosa R, Ancona-Alayon A, Arevalo-Lopez A (2000) Allergic contact dermatitis to socks presenting as bleached rubber syndrome. Am J Contact Dermat 11:97–98

    Article  PubMed  CAS  Google Scholar 

  • Bourrain JL, Woodward C, Dumas V, et al (1996) Natural rubber latex contact dermatitis with features of erythema multiforme. Contact Dermatitis 35:55–56

    Article  PubMed  CAS  Google Scholar 

  • Brandão FM (1990) Rubber. In: Adams RM (ed). Occupational skin disease. Philadelphia, Saunders, pp 462–485

    Google Scholar 

  • Bruze M, Trulsson L, Bendsöe N (1992) Patch testing with ultrasonic bath extracts. Am J Contact Dermatitis 3:133–137

    Google Scholar 

  • Burrows D (1972) Thiuram dermatitis and purpura. Contact Dermatitis Newsletter 12:333

    Google Scholar 

  • Calnan CD (1971) Liehenoid dermatitis from isopropylaminodiphenylamine. Contact Dermatitis Newsletter 10:237

    Google Scholar 

  • Calnan CD (1978) Dermatology and industry. Prosser White Oration 1977. Clin Exp Dermatol 3:1–16

    Article  PubMed  CAS  Google Scholar 

  • Condé-Salazar L (1987) Dermatosis por gomas y derivados. In: Tratado de dermatosis profesionales. Garcia Perez A, Condé-Salazar L, Camarasa JM (eds). Madrid: Eudema, pp 157–181

    Google Scholar 

  • Condé-Salazar L (1990a) Sensibilidad profesional a componentes de las gomas. Doctoral thesis, University of Madrid

    Google Scholar 

  • Condé-Salazar L (1990b) Rubber dermatitis: Clinical forms. Dermatol Clin 8:49–55

    Article  PubMed  Google Scholar 

  • Condé-Salazar L, del Rio E, Guimaraens D, et al (1993) Type IV allergy to rubber additives. A 10-year study of 686 cases. J Am Acad Dermatol 29:176–180

    Article  PubMed  Google Scholar 

  • Condé-Salazar L, Guimaraens D, Villegas C, et al (1995) Occupational Allergic contact dermatitis in construction workers. Contact Dermatitis 33:226–230

    Article  PubMed  Google Scholar 

  • Cronin E (1980) Rubber. In: Cronin E (ed) Contact dermatitis. Churchill Livingstone, Edinburgh, pp 714–770

    Google Scholar 

  • de Groot AC (1994) Patch Testing: Test Concentrations and Vehicles for 3700 Chemicals, 2nd edn. Elsevier, Amsterdam

    Google Scholar 

  • de Meester C (1988) Genotoxic properties of 1,3-butadiene. Mutat Res 195:273–281

    Article  PubMed  Google Scholar 

  • Dooms-Goossens A, Loncke J, Miehiels JL, et al (1985) Pustular reactions to hexafluorosilicate in foam rubber. Contact Dermatitis 12:42–47

    Article  PubMed  CAS  Google Scholar 

  • Dooms-Goossens A, Debusschere KM, Gevers DM, et al (1986) Contact dermatitis caused by airborne agents: a review and case reports. J Am Acad Dermatol 15:1–10

    Article  PubMed  CAS  Google Scholar 

  • Duarte I, Terumi-Nakono J, Lazzarini R (1998) Hand eczema: evaluation of 250 patients. Am J Contact Dermat 9:216–223

    Article  PubMed  CAS  Google Scholar 

  • Estlander T (1990) Occupational skin disease in Finland. Observations made during 1974–1988 at the Institute of Occupational Health, Helsinki. Acta Derm Venereol Suppl (Stockh) 155:1–85

    CAS  Google Scholar 

  • Estlander T, Jolanki R, Kanerva L (1986) Dermatitis and urticaria from rubber and plastic gloves. Contact Dermatitis 14:20–25

    Article  PubMed  CAS  Google Scholar 

  • Eun HC, Park HB, Chun YH (1985) Occupational pitted keratolysis. Contact Dermatitis 12:122

    Article  PubMed  CAS  Google Scholar 

  • Fajen JM, Roberts DR, Ungers LJ, et al (1990) Occupational exposure of workers to 1,3-butadiene. Environ Health Perspect 86:11–18

    Article  PubMed  CAS  Google Scholar 

  • Feinman SE (1987) Sensitivity to rubber chemicals. J Toxicol Cut Ocular Toxicol 6:117–153

    Article  Google Scholar 

  • Fishbein L (1992) Exposure from occupational versus other sources. Scand J Work Environ Health 18 (Suppl 1):5–16

    PubMed  CAS  Google Scholar 

  • Fisher AA (1974) Allergic petechial and purpuric rubber dermatitis: The PPPP syndrome. Cutis 14:25–27

    Google Scholar 

  • Fisher AA (1975) “Hypoallergenic” surgical gloves and gloves for special situations. Cutis 15:797–811

    Google Scholar 

  • Foussereau J, Cavelier C, Protois JC, et al (1988) A case of erythema multiforme with allergy to isopropyl-p-phenylenediamine of rubber. Contact Dermatitis 18:183

    Article  PubMed  CAS  Google Scholar 

  • Fregert S (1975) Occupational dermatitis in a 10-year material. Contact Dermatitis 1:96–107

    Article  PubMed  CAS  Google Scholar 

  • Fregert S (1981) Manual of Contact Dermatitis, 2nd edn. Munksgaard, Copenhagen, pp 46–48

    Google Scholar 

  • Fregert S, Skog E (1962) Allergic contact dermatitis from mercaptobenzothiazole in cutting oil. Acta Derm Venereol (Stockh) 42:235–238

    CAS  Google Scholar 

  • Fregert S, Trulsson L, Zimerson E (1982) Contact allergic reactions to diphenylthiourea and phenylisothiocyanate in PVC adhesive tape. Contact Dermatitis 8:38–42

    Article  PubMed  CAS  Google Scholar 

  • Gibbon KL, McFadden JP, Rycroft RJ et al (2001) Changing frequency of thiuram allergy in healthcare workers with hand dermatitis. Br J Dermatol 144:347–350

    Article  PubMed  CAS  Google Scholar 

  • Hansson C (1994) Allergic contact dermatitis from N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine and from compounds in polymerized 2,2,4-trimethyl-l,2-dihydroquinoline. Contact Dermatitis 30:114–115

    Article  PubMed  CAS  Google Scholar 

  • Heese A, van Hintzenstern J, Peters KP, et al (1991) Allergic and irritant reactions to rubber gloves in medical health services. J Am Acad Dermatol 25:831–839

    Article  PubMed  CAS  Google Scholar 

  • Helland S, Nyfors A, Utne L (1983) Contact dermatitis to Synthaderm®. Contact Dermatitis 9:504–506

    Article  PubMed  CAS  Google Scholar 

  • Hervé-Bazin B, Gradiski D, Duprat P, et al (1977) Occupational eczema from N-isopropyl-N'-phenylparaphenylenediamine (IPPD) and N-dimethy-l,3-butyl-N'-phenylparaphenylenediamine (DMPPD) in tyres. Contact Dermatitis 3:1–15

    Article  PubMed  Google Scholar 

  • International Agency for Research on eancer (IARC, 1979) Some monomers, plastics and synthetie elastomers, and acrolein. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans 19:231

    Google Scholar 

  • International Agency for Research on cancer (IARC, 1986) Some chemicals used in plastics and elastomers. In: IARC monographs on the evaluation of carcinogenic risk of chemicals to humans 39:155

    Google Scholar 

  • Jordan WP Jr, Bourlas MC (1975) Allergic contact dermatitis to underwear elastic. Arch Dermatol 111:593–595

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Iolanki R, Plosila M, et al (1984) Contact dermatitis from dibutylthiourea. Contact Dermatitis 10:158–162

    Article  PubMed  CAS  Google Scholar 

  • Kanerva L, Estlander T, Jolanki R (1996) Allergic patch test reactions caused by the rubber chemieal cyclohexyl thiophthalimide. Contact Dermatitis 34:23–26

    Article  PubMed  CAS  Google Scholar 

  • Kaniwa MA, Isama K, Nakamura A, et al (1994a) Identification of causative chemicals of Allergic contact dermatitis using a combination of patch testing in patients and chemical analysis: Application to cases from rubber footwear. Contact Dermatitis 30:26–34

    Article  PubMed  CAS  Google Scholar 

  • Kaniwa MA, Isama K, Nakamura A, et al (1994b) Identification of causative chemicals of Allergic contact dermatitis using a combination of patch testing in patients and chemical analysis: Application to cases from rubber gloves. Contact Dermatitis 31:65–71

    Article  PubMed  CAS  Google Scholar 

  • Kilpikari I (1982) Occupational contact dermatitis among rubber workers. Contact Dermatitis 8:359–362

    Article  PubMed  CAS  Google Scholar 

  • Kilpikari I, Halme H (1983) Contact allergy to Hypalon® rubber. Contact Dermatitis 9:529

    Article  PubMed  CAS  Google Scholar 

  • Knudsen BB, Menne T (1996) Contact allergy and exposure patterns to thiurams and carbamates in consecutive patients. Contact Dermatitis 35:97–99

    Article  PubMed  CAS  Google Scholar 

  • Knudsen BB, Hametner C, Seycek O et al (2000) Allergologically relevant rubber accelerators in single-use medical gloves. Contact Dermatitis 43:9–15

    Article  PubMed  CAS  Google Scholar 

  • Ko D, Leow YH, Goh CL (2001) Occupational Allergic contact dermatitis in Singapore. Sci Total Environ 270:97–101

    Article  PubMed  CAS  Google Scholar 

  • Lammintausta K, Kalimo K (1985) Sensitivity to rubber. Study with rubber mixes and individual rubber chemicals. Dermatosen 33:204–208

    CAS  Google Scholar 

  • Lenane P, McKenna D, Murphy GM (1998) Pyoderma gangrenosum secondary to Allergic contact dermatitis from rubber. Contact Dermatitis 38:238

    Article  PubMed  CAS  Google Scholar 

  • Magnusson B, Möller H (1979) Contact allergy without skin disease. Acta Derm Venereol (Stockh) 59 (Suppl):113–115

    CAS  Google Scholar 

  • Marks JG, Belsito DV, DeLeo VA, et al (1995) North American Contact Dermatitis Group standard tray patch test results (1992 to 1994). Am J Cont Derm 6:160–165

    Article  Google Scholar 

  • Marks JG, Belsito DV, DeLeo VA, et al (1998) North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. J Am Acad Dermatol 38:911–918

    Article  PubMed  CAS  Google Scholar 

  • Marks JG, Belsito DV, DeLeo, VA et al (2000) North American ontact Dermatitis Group Patch Test Results: 1996–1998. Arch Dermatol 136:272–273

    Article  PubMed  Google Scholar 

  • Mitchell JM, Rook A (1979) Botanical dermatology. Vancouver, Greengrass, p 286

    Google Scholar 

  • Nater JP, Terpstra H, Bleumink F (1979) Allergic contact sensitization to the fungicide Maneb. Contact Dermatitis 5:24–26

    Article  PubMed  CAS  Google Scholar 

  • National Institute for Occupational Safety and Health (NIOSH, 1984) 1,3-Butadiene. In: Current Intelligence Bulletin; no 41, publieation no 84-105. Cincinnati, OH. US Department of Health and Human Services, NIOSH

    Google Scholar 

  • Nethercott JR (1982) Results of routine patch testing of 200 patients in Toronto. Contact Dermatitis 8:389–395

    Article  PubMed  CAS  Google Scholar 

  • Nethercott JR, Holness DL, Adams RM, et al (1991) Patch testing with a routine screening tray in North America, 1985 through 1989: I. Frequency of response. Am J Contact Dermatitis 2:122–129

    Google Scholar 

  • Norris P, Storrs FJ (1990) Allergic contact dermatitis to adhesive bandages. Dermatol Clin 8:147–152

    PubMed  CAS  Google Scholar 

  • Nurse DS (1979) Rubber sensitivity. Austr J Dermatol 20:31–33

    Article  CAS  Google Scholar 

  • Nutter AF (1979) Contact urticaria to rubber. Br J Dermatol 101:597–598

    Article  PubMed  CAS  Google Scholar 

  • Oliver EA, Schwartz L, Warren LH (1939) Occupational leukoderma: Preliminary report. JAMA 113:927–928

    Article  Google Scholar 

  • Pecegueiro S, Brandão F (1984) Contact plantar pustulosis. Contact Dermatitis 11:126–127

    Article  PubMed  CAS  Google Scholar 

  • Plotnick HB (1978) Carcinogenesis in rats of combined ethylene dibromide and disulfiram. JAMA 239:1609

    Article  PubMed  CAS  Google Scholar 

  • Plotnick H, Birmingham DJ (1993) Disulfiram alcohol facial flush in rubber industry. Abstracts: American Contact Dermatitis Society Annual Meeting, Washington, DC, p 11

    Google Scholar 

  • Rich P, Belozer ML, Norris P, et al (1991) Allergic contact dermatitis to two antioxidants in latex gloves: 4,4'-thiobis(6-tert-butyl-meta-cresol) (Lowinox 44S36) and butylhydroxyanisole: Allergic alternatives for glove-allergic patients. J Am Acad Dermatol 24:37–43

    Article  PubMed  CAS  Google Scholar 

  • Rietschel RL (1984) Role of socks in shoe dermatitis. Arch Dermatol 120:398

    Article  PubMed  CAS  Google Scholar 

  • Rietschel RL, Fowler JF, Jr, (2001) Fisher’s contact dermatitis, 5th edn. Lippincott William and Wilkins, Philadelphia

    Google Scholar 

  • Rodriguez E, Reynolds GW, Thompson JA (1981) Potent contact allergen in the rubber plant guayule (Parthenium argentatum). Science 21:1444–1445

    Article  Google Scholar 

  • Rogers TH, Jr (1974) Natural Rubber. In: Chemieal and process technology encydopedia. Considine DM (ed), New York, McGraw-Hill. p 984

    Google Scholar 

  • Romaguera C, Grimalt F (1977) PPPP syndrome. Contact Dermatitis 3:102–103

    Article  PubMed  CAS  Google Scholar 

  • Rubber World Magazine’s Blue Book (2001). Lippincott and Peto, Inc., Philadelphia. PA

    Google Scholar 

  • Rudner EJ, Clendenning WE, Epstein E, et al (1975) The frequency of contact sensitivity in North America 1972–1974. Contact Dermatitis 1:277–280

    Article  Google Scholar 

  • Rudzki E, Napiorkowska T, Czerwinska-Dihm I (1981) Dermatitis from 2-mercaptobenzothiazole in photographie films. Contact Dermatitis 7:43

    Article  PubMed  CAS  Google Scholar 

  • Shackelford KE, Belsito DV (2002) The etiology of allergic-appearing foot dermatitis: a 5-year retrospective study. J Am Acad Dermatol 47:715–721

    Article  PubMed  Google Scholar 

  • Shelley WB (1964) Golf-course dermatitis due to thiram fungicide. JAMA 188:415–417

    Article  PubMed  CAS  Google Scholar 

  • Sidi E, Hincky M (1954) Les eczemas aux gants de caout. Presse Med 62:1305–1307

    PubMed  CAS  Google Scholar 

  • Stankevieh VV, Vlasiuk MG, Prokof’eva LG (1980) Hygienic assessment of organosulfur accelerators for vuleanization of rubbers for the food industry. Gig Sanit 10:88–89

    Google Scholar 

  • Storrs FJ, Rosenthai LE, Adams RM, et al (1989) Prevalence and relevance of allergic reactions in patients patch tested in North America — 1984 to 1985. J Am Acad Dermatol 20:1038–1045

    Article  PubMed  CAS  Google Scholar 

  • Taylor JS (1986) Rubber. In: Contact Dermatitis. Fisher AA (ed). Lea and Febiger, Philadelphia, pp 603–643

    Google Scholar 

  • Themido R, Brandão FM (1984) Contact allergy to thiurams. Contact Dermatitis 10:251

    Article  PubMed  CAS  Google Scholar 

  • Turjanmaa K, Alenius H, Mäkinen-Kiljunen S, Reunala T, Palosuo T (2000) Natural rubber latex allergy. In: Kanerva L, Elsner P, Wahlberg JE, Maibach HI (eds) Handbook of occupational dermatology. Springer, Heidelberg Berlin New York, pp 719–729

    Google Scholar 

  • Toeppen-Sprigg B (1999) Management of dermatitis in the rubber manufacturing industry. Occup Med 14:797–818

    PubMed  CAS  Google Scholar 

  • van der Leun JC, de Kreek EJ, Deenstra-vanLeeuwen M, et al (1977) Photosensitivity owing to thiourea. Arch Dermatol 113:1611

    PubMed  Google Scholar 

  • Varigos GA, Dunt DR (1981) Occupational dermatitis. An epidemiological study in the rubber and cement industries. Contact Dermatitis 7:105–110

    Article  PubMed  CAS  Google Scholar 

  • Vestey JP, Gawkrodger DJ, Wong WK, et al (1986) An analysis of 501 consecutive contact clinic consultations. Contact Dermatitis 15:119–125

    Article  PubMed  CAS  Google Scholar 

  • von Hintzenstern J, Heese A, Koch HU, et al (1991) Frequency, spectrum and occupational relevance of type IV allergics to rubber chemicals. Contact Dermatitis 24:244–252

    Article  Google Scholar 

  • White IR (1988) Dermatitis in rubber manufacturing industries. Dermatologic Clinies 6:53–59

    CAS  Google Scholar 

  • Wilkinson SM, Beck MH (1993) Allergic contact dermatitis from sealants containing polysulphide polymers (Thiokol®). Contact Dermatitis 29:273–274

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson SM, Beck MH (1996) Allergic contact dermatitis from latex rubber. Br J of Dermatol 134:910–914

    Article  CAS  Google Scholar 

  • Wilson HT (1960) Rubber-glove dermatitis. Br Med J 2:21–23

    Article  PubMed  CAS  Google Scholar 

  • World Health Organization (WHO 1983). Styrene. In: Environmental Health Criteria; no 26, WHO, Geneva

    Google Scholar 

  • Wyss M, Elsner P, Wuthrich B, et al (1993) Allergic contact dermatitis from natural latex without contact urticaria. Contact Dermatitis 28:154–156

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Belsito, D.V. (2004). Rubber Chemicals. In: Kanerva, L., Elsner, P., Wahlberg, J.E., Maibach, H.I. (eds) Condensed Handbook of Occupational Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18556-4_39

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18556-4_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-44348-3

  • Online ISBN: 978-3-642-18556-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics