Abstract
A previous study demonstrated that suramin reduces the proliferation of human pancreatic cancer cells in vitro and also reduces the secretion of the proangiogenic key factor VEGF This study examined the effect of suramin on tumor growth, metastasis and angiogenesis in vivo in an orthotopic nude mouse model.
1 mm3 fragments from 3 human pancreatic cancer cell lines (MIAPaCa-2, AsPC-1 and Capan 1) were orthotopically implanted in the pancreas of the nude mice. Volume of primary tumor, local infiltration, metastasis and microvascular density (MVD) were determined at autopsy. To assess the effect of suramin on angiogenesis, other tumor bearing animals were treated with a specific inhibitor of angiogenesis (TNP-470).
Suramin at low concentrations (10 mg/kg) had no influence on tumor growth, metastasis or angiogenesis in MIAPaCa-2 tumors. At high concentrations (60 mg/kg) Suramin reduced primary tumor growth and dissemination in all 3 pancreatic carcinomas. Suramin inhibited the MVD, but not as strong as the specific angiogenesis inhibitor TNP-470.
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Literatur
Porebski A, Hotz HG, Hotz B, Buhr HJ (2003) Suramin hemmt das Wachstum des humanen Pankreaskarzinoms in vitro und in vivo. Forum-Band 120. Kongress der DGCH
Hotz HG, Reber HA, Hotz B, Sanghavi PC, Yu T, Foitzik T, Buhr HJ, Hines OJ (2001) Angiogenesis inhibitor TNP-470 reduces human pancreatic cancer growth. J Gastrointest Surg. 5:131–138
Hotz HG, Reber HA, Hotz B, Yu T, Foitzik T, Buhr HJ, Cortina G, Hines OJ (2003) An orthotopic nude mouse model for evaluating pathophysiology and therapy of pancreatic cancer. Pancreas 26:E89–E98
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© 2004 Springer-Verlag Berlin Heidelberg
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Porebski, A., Hotz, B., Buhr, H.J., Hotz, H.G. (2004). Suramin hemmt neben Tumorwachstum und Metastasierung auch die Angiogenese beim experimentellen Pankreaskarzinom. In: Ulrich, B., Jauch, KW., Bauer, H., Menger, M.D., Laschke, M., Slotta, J. (eds) Chirurgisches Forum 2004. Deutsche Gesellschaft für Chirurgie, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18547-2_9
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DOI: https://doi.org/10.1007/978-3-642-18547-2_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20027-7
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