Abstract
Variable gene expression patterns of the tissue inhibitor of metallo-proteinase 1 and 2 (TIMP1 and TIMP2) in the wall of spontaneous aortic aneurysms suggest that the phenotype may be associated with functional genetic variants of those genes. Thus, we have analyzed the coding sequences of the TIMP1- and TIMP2-gene in a group of 50 patients with abdominal aortic aneurysm and in a control group of 48 healthy individuals. We have identified 3 new single nucleotide polymorphisms (SNP). An association described by Wang et al. [1] of the SNP TIMP2 nt 573 G/A with the phenotype could not be shown in our population.
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Wang X, Tromp G, Cole W, Verloes A, Sakalihasan N, Yoon S, Kuivaniemi H (1999) Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol 18:121–124
Campa JS, Greenhalgh RM, Powell JT (1987) Elastin degradation in abdominal aortic aneurysms. Atherosclerosis 65:13–21
Annabi B, Shédid D, Ghosn P, Kenigsberg RL, Desrosiers RR, Bojanowski MW, Beaulieu E, Nassif E, Moumdjian R, Béliveau R (2002) Differential regulation of matrix metalloproteinase activities in abdominal aortic aneurysms. J Vase Surg 35:539–546
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Hinterseher, I., Krex, D., Bergert, H., Kuhlisch, E., Saeger, H.D. (2004). Genomische Analyse der Tissue Inhibitors of Metalloproteinases 1 und 2 (TIMP1 und TIMP2) als potentielle ätiologische Faktoren spontaner Aortenaneurysmen. In: Ulrich, B., Jauch, KW., Bauer, H., Menger, M.D., Laschke, M., Slotta, J. (eds) Chirurgisches Forum 2004. Deutsche Gesellschaft für Chirurgie, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18547-2_30
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DOI: https://doi.org/10.1007/978-3-642-18547-2_30
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20027-7
Online ISBN: 978-3-642-18547-2
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