Abstract
In colorectal cancer and other malignancies, thymidine phosphorylase (TP) activates 5-fluorouracil (5-FU) while promoting tumor angiogenesis at the same time via the generation of 2-deoxy-D-ribose (dRib). Here, we show that addition of rapamycin, an immunosuppressive agent with newly discovered antiangiogenic properties, to 5-FU cytotoxic chemotherapy strongly suppresses orthothopic and metastatic colon tumor growth in mice. Moreover, in vitro results from Boyden chamber and aortic ring experiments demonstrate that rapamycin inhibits different steps of TP/dRib-induced angiogenesis. Taken together, the combination of 5-FU with rapamycin may be a promising approach in advanced colorectal cancer.
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Seeliger, H., Guba, M., Koehl, G., Bruns, C.J., Jauch, K.W., Geissler, E.K. (2004). Rapamycin potenziert die Wirkung von 5-FU beim Thymidinphosphorylase exprimierenden kolorektalen Karzinom durch Inhibition 2-deoxy-D-Ribose vermittelter Angiogenese. In: Ulrich, B., Jauch, KW., Bauer, H., Menger, M.D., Laschke, M., Slotta, J. (eds) Chirurgisches Forum 2004. Deutsche Gesellschaft für Chirurgie, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18547-2_10
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DOI: https://doi.org/10.1007/978-3-642-18547-2_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-20027-7
Online ISBN: 978-3-642-18547-2
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