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Calciumantagonisten

  • Thomas Eschenhagen
  • Hasso Scholz

Zusammenfassung

Hauptgruppen der Calciumantagonisten sind die Dihydropyridine und die relativ stärker kardiodepressiv wirkenden Substanzen Verapamil und Diltiazem.

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Literatur

  1. Agodoa LY, Appel L, Bakris GL, Beck G, Bourgoignie J, Briggs JP et al for the African American Study of Kidney Disease and Hypertension (AASK) Study Group (2001): Effect of ramipril vs amlodipine on renal outcomes in hypertensive nephrosclerosis. A randomized controlled trial. JAMA 285:2719–2728.PubMedCrossRefGoogle Scholar
  2. Arzneimittelkommission der deutschen Ärzteschaft (1997): Calciumantagonisten vom 1,4-Dihydropyridin-Typ. Dtsch Ärztebl 22: C-1122–C-1123.Google Scholar
  3. Blood Pressure Lowering Treatment Trialists’ Collaboration (2000): Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Lancet 356: 1955–1964.CrossRefGoogle Scholar
  4. Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL et al and the National High Blood Pressure Education Program Coordinating Committee (2003): The seventh report on the joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. JAMA 289: 2560–2572.PubMedCrossRefGoogle Scholar
  5. Cohn JN, Ziesche SM, Loss LE, Anderson GF, V-HeFT Study Group (1995): Effect of felodipine on short-term exercise and neurohormone and long-term mortality in heart failure: Results of V-HeFT VIII. Circulation 92:1–143.CrossRefGoogle Scholar
  6. European Society of Cardiology (1997): Management of stable angina pectoris: recommendations of the Task Force of the European Society of Cardiology. Eur Heart J 18: 394–413.CrossRefGoogle Scholar
  7. Furberg C, Psaty BM, Meyer JS (1995): Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 92:1326–1331.PubMedCrossRefGoogle Scholar
  8. Heidenreich PA, McDonald KM, Hastie T, Fadel B, Hagan V, Lee BK, Hlatky MA (1999): Meta-analysis of trials comparing β-blockers, calcium antagonists, and nitrates for stable angina. JAMA 281:1927–1936.PubMedCrossRefGoogle Scholar
  9. Jørgensen B, Simonsen S, Endresen K, Forfang K, Vatne K, Hansen J et al (2000): Restenosis and clinical outcome in patients treated with amlodipine after angioplasty: results from the Coronary Angioplasty Amlodipine REStenosis Study (CAPARES). J Am Coll Cardiol 35: 592–599.PubMedCrossRefGoogle Scholar
  10. Lewis EJ, Hunsicker LG, Clarke WR, Berl T, Pohl MA, Leiws JB et al (2001): Renopro-tective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 345:851–60.PubMedCrossRefGoogle Scholar
  11. Lüscher TF, Wenzel RR, Noll G (1996): Calciumantagonisten in der Kontroverse: Gibt es eine rationale Differentialtherapie? Dtsch Med Wochenschr 121:532–538.PubMedCrossRefGoogle Scholar
  12. North of England Stable Angina Guideline Development Group (1996): North of England evidence based guidelines development project. BMJ 312: 827–832.CrossRefGoogle Scholar
  13. Packer M (1989): Combined beta-adrenergic and calcium-entry blockade in angina pectoris. N Engl J Med 320:709–718.PubMedCrossRefGoogle Scholar
  14. Packer M, O’Connor CM, Ghali JK, Pressler ML, Carson PE et al (1996): Effect of amlodipine on morbidity and mortality in severe chronic heart failure. N Engl J Med 335:1107–1114.PubMedCrossRefGoogle Scholar
  15. Pahor M, Psaty BM, Furberg CD (1998): Treatment of hypertensive patients with diabetes. Lancet 351:689–690.PubMedCrossRefGoogle Scholar
  16. Pahor M, Psaty BM, Alderman MH, Applegate WB, Williamson JD, Cavazzini C, Furberg CD (2000): Health outcomes associated with calcium antagonists compared with other first-line antihypertensive therapies: a meta-analysis of randomised controlled trials. Lancet 356:1949–1954.PubMedCrossRefGoogle Scholar
  17. Pitt B, Byington RP, Furberg CD, Hunninghake DB, Mancini J, Miller ME, Riley W for the PREVENT Investigators (2000): Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. Circulation 102:1503–1510.PubMedCrossRefGoogle Scholar
  18. Psaty BM, Heckbert SR, Koepsell TD, Siscovick DS, Raghunathan TE et al (1995): The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA 274: 620–625.PubMedCrossRefGoogle Scholar
  19. Scholz H (1987): Wechselwirkungen zwischen Beta-Rezeptorenblockern und Anti-arrhythmika. In: Grosdanoff P et al (Hrsg): Beta-Rezeptoren und Beta-Rezepto-renblocker, Walter de Gruyter & Co, Berlin New York: S. 255–271.Google Scholar
  20. Staessen JA, Fagard R, Thijs L, Celis H, Arabidze GG et al (1997): Randomised double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension. The Systolic Hypertension in Europe (Syst-Eur) Trial Investigators. Lancet 350: 757–764.PubMedCrossRefGoogle Scholar
  21. Tatti P, Pahor M, Byington RP, Di Mauro P, Guarisco R, Strollo G, Strollo F (1998): Outcome results of the Fosinopril Versus Amlodipine Cardiovascular Events Randomized Trial (FACET) in patients with hypertension and NDDM. Diabetes Care 21: 597–603.PubMedCrossRefGoogle Scholar
  22. The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002): The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 288: 2981–2997.Google Scholar
  23. The Defiant-II Research Group (1997): Doppler flow and echocardiography in functional cardiac insufficiency: Assessment of nisoldipine therapy. Results of the DEFIANT-II study. Eur Heart J 18: 31–40.CrossRefGoogle Scholar
  24. Tuomilehto J, Rastenyte D, Birkenhäger WH, Thjs L, Antikainen R et al (1999): Effects of calcium-channel blockade in older patients with diabetes and systolic hypertension. N Engl J Med 340: 677–684.PubMedCrossRefGoogle Scholar
  25. Viberti G, Wheeldon NM for the MicroAlbuminuria Reduction With VALsartan (MARVAL) Study Investigators (2002): Microalbuminuria reduction with valsartan in patients with typ 2 diabetes mellitus. Circulation 106: 672–678.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2004

Authors and Affiliations

  • Thomas Eschenhagen
    • 1
  • Hasso Scholz
    • 1
  1. 1.Institut für Experimentelle und Klinische PharmakologieUniversitäts-Krankenhaus EppendorfHambury

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