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Angiotensin-(1–7). Its Contribution to Arterial Pressure Control Mechanisms

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Book cover Angiotensin Vol. I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 163 / 1))

Abstract

A formidable body of evidence accumulated to date reveals the pleio-tropic actions of the renin-angiotensin system and its role in cardiovascular medicine. The characterization of the biological actions of angiotensin-(1-7) expanded knowledge of the endogenous control mechanisms regulating the actions of angiotensin II and revealed alternate enzymatic pathways for the processing of angiotensin I and angiotensin II. The following chapter reviews the tissue-specific pathways for formation and metabolism of this member of the renin-angiotensin system as well as its localization within brain, renal, and cardiac tissue. The unique actions of angiotensin-(1-7) in general oppose those of angiotensin II, and the preponderance of data identifies the regulation of the balance between the two peptides as important to overall cardiovascular health. We emphasize the physiological actions of the peptide in vascular, neural, and renal systems and provide a comprehensive review of its trophic and signaling mechanisms. The current status of the receptors mediating the actions of the peptide and the potential for non-receptor mechanisms are also presented. Finally, we discuss the significance of angiotensin-(1-7) in human disease, based on evidence emerging from recent studies suggesting that deficits in angiotensin-(1-7) are associated with hypertension in specific subpopulations of patients.

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Authors and Affiliations

  1. Hypertension and Vascular Disease Center, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA

    C. M. Ferrario, D. B. Averill, K. B. Brosnihan, M. C. Chappell, D. I. Diz, P. E. Gallagher & E. A. Tallant

Authors
  1. C. M. Ferrario
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  2. D. B. Averill
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  3. K. B. Brosnihan
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  4. M. C. Chappell
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  5. D. I. Diz
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  6. P. E. Gallagher
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  7. E. A. Tallant
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Editors and Affiliations

  1. Center for Cardiovascular Research (CCR) Institut für Pharmakologie und Toxikologie Charité Campus Mitte, Charité — Universitätsmedizin Berlin, Hessische Strasse 3-4, 10115, Berlin, Germany

    Thomas Unger

  2. Drug Innovation & Approval, Aventis Pharma Deutschland GmbH, Bldg. H 831, Room C 320, 65926, Frankfurt/Main, Germany

    Bernward A. Schölkens

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© 2004 Springer-Verlag Berlin Heidelberg

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Ferrario, C.M. et al. (2004). Angiotensin-(1–7). Its Contribution to Arterial Pressure Control Mechanisms. In: Unger, T., Schölkens, B.A. (eds) Angiotensin Vol. I. Handbook of Experimental Pharmacology, vol 163 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18495-6_21

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  • DOI: https://doi.org/10.1007/978-3-642-18495-6_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-40640-2

  • Online ISBN: 978-3-642-18495-6

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