Abstract
The continuous infusion (CI) of coagulation factor-VIII (FVIII) concentrates has been used since the early 1990s. Compared to the traditional way of factor application by episodic bolus infusions (BI) the CI had several advantages:
Steady level of missing coagulation factor, avoiding of unnecessary high peaks of FVIII, saving of 30% FVIII concentrate and reduction in treatment costs [1]. Reports of the occurrence of an inhibitor after treatment with CI have raised concerns about this method of factor application.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Batorova A, Martinowitz U. Continuous infusion of coagulation factors. Haemophilia 2002; 8: 170–177
Oldenburg J, El-Maarri O, Schwaab R. Inhibitor development in correlation to FVIII genotypes. Haemophilia, 2002; 8(Suppl.2): 23–29
Hermans C, Thyn Ye e T, Perry D, Lee C. Development of inhibitor in hemophilia patients treated with continuous infusion. Haemophilia 2002; 8: 541
Koestenberger M, Raith W, Muntean W. High titre inhibitor after continuous factor VIII administration for surgery in a young infant. Haemophilia 2000; 6: 120
White B, Cotter M, Byrne M, O’Shea E, Smith OP. High responding factor VIII inhibitors in mild hemophilia — is there a link with recent changes in clinical practice? Haemophilia, 2000; 6: 113–115
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2004 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Auer, C.v. et al. (2004). A Retrospective Study on the Development of Inhibitors after Continuous Infusion of Factor VIII. In: Scharrer, I., Schramm, W. (eds) 33rd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18260-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-18260-0_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-00902-3
Online ISBN: 978-3-642-18260-0
eBook Packages: Springer Book Archive