Skip to main content

HPV Diagnostik als Voraussetzung zu neuen Präventions-und Therapiekonzepten beim Zervixkarzinom

  • Conference paper
54. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe
  • 299 Accesses

Zusammenfassung

Weltweit entwickeln ca. 1/2 Million Frauen ein Zervixkarzinom.Die Inzidenz ist in sogenannten Entwicklungsländern drei Mal höher als in Ländern, in denen eine Krebsfrüherkennung betrieben wird. Die ursächliche Beziehung zwischen der Infektion durch sogenannte high-risk (HR) Typen humaner Papillomviren (HPV 16, 18 und andere) und Zervixkarzinom gilt als gesichert.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 119.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bosch FX, Rohan T, Schneider A, Frazer I, Pfister H, Castellsague X, Puig Tintore LM, Munoz N, zur HH (2001) Papillomavirus Research: Updating results to the year 2000. Highlights of the HPV 2000 International Papillomavirus conference. J Clin Pathol 54: 0–13

    Article  Google Scholar 

  2. de Roda Husman AM, Walboomers JMM, van den Brule AJC, Meijer CLJM, Snijders PJF (1995) The use of general primers GP5 and GP6 elongated at their 3′ ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR. J Gen Virol 76:1057–1062

    Article  PubMed  Google Scholar 

  3. Elfgren K, Bistoletti P, Dillner L, Walboomers JM, Meijer CJ, Dillner J (1996) Conization for cervical intraepithelial neoplasia is followed by disappearance of human papillomavirus deoxyribonucleic acid and a decline in serum and cervical mucus antibodies against human papillomavirus antigens. Am J Obstet Gynecol 174:937–942

    Article  PubMed  CAS  Google Scholar 

  4. Goldstone, SE, Neefe JR, Winnett MT, Palefsky JM (2001 ) HSPE7 treatment of high grade anal dysplasia: Updated results of an ongoing open label trial. 19th International Papillomavirus Conference, Florianapolis (Brazil), Ludwig Institute for Cancer Research, p 68

    Google Scholar 

  5. Gravitt PE, Peyton CL, Alessi TQ, Wheeler CM, Coutlee F, Hildesheim A, Schiffman MH, Scott DR, Apple RJ (2000) Improved amplification of genital human papillomaviruses. J Clin Microbiol 38(1): 357–361

    PubMed  CAS  Google Scholar 

  6. Harro CD, Pang YY, Roden RB, Hildesheim A, Wang Z, Reynolds MJ, Mast TC, Robinson R, Murphy BR, Karron RA, Dillner J, Schiller JT, Lowy DR (2001) Safety and Immunogenicity Trial in Adult Volunteers of a Human Papillomavirus 16 L1 Virus-Like Particle Vaccine. J Natl Cancer Inst 93: 284–292

    Article  PubMed  CAS  Google Scholar 

  7. Hillemanns P (1999) Screening for cervical neoplasia by self-assessment for human papillomavirus DNA. Lancet

    Google Scholar 

  8. Josefsson AM, Magnusson PK, Ylitalo N, Sorensen P, Qwarforth-Tubbin P, Andersen PK, Melbye M, Adami HO, Gyllensten UB (2000) Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study. Lancet 355: 2189–2193

    Article  PubMed  CAS  Google Scholar 

  9. Kim JJ, Wright TC, Goldie SJ (2002) Cost-effectiveness of alternative triage strategies for atypical squamous cells of undetermined significance. JAMA 287: 2382–2390

    Article  PubMed  Google Scholar 

  10. Klaes R, Woerner SM, Ridder R, Wentzensen N, Duerst M, Schneider A, Lotz B, Melsheimer P, von Knebel-Doeberitz M (1999) Detection of high-risk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 59:6132–6136

    PubMed  CAS  Google Scholar 

  11. Knutson KL (2001) Technology evaluation: T-cell activator,Xenova. Curr Opin Mol Ther 3:585–588

    PubMed  CAS  Google Scholar 

  12. Mandelblatt JS, Lawrence WF, Womack SM, Jacobson D, Yi B, Hwang YT, Gold K, Barter J, Shah K (2002) Benefits and costs of using HPV testing to screen for cervical cancer. JAMA 287:2372–2381

    Article  PubMed  Google Scholar 

  13. Manos MM, Kinney WK, Hurley LB, Sherman ME, Shieh NJ, Kurman RJ, Ransley JE, Fetterman BJ, Hartinger JS, McIntosh KM, Pawlick GF, Hiatt RA (1999) Identifying women with cervical neoplasia: using human papillomavirus DNA testing for equivocal Papanicolaou results. JAMA 281: 1605–1610

    Article  PubMed  CAS  Google Scholar 

  14. Manos MM, Ting Y, Wright DK, Lewis AJ, Broker TR, Wolinsky SM (1989) The use of polymerase chain reaction amplification for the detection of genital human papillomaviruses. Cancer Cells 7: 209–214

    CAS  Google Scholar 

  15. Muderspach L, Wilczynski S, Roman L, Bade L, Felix J, Small LA, Kast WM, Fascio G, Marty V, Weber J (2000) A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive. Clin Cancer Res 6: 3406–3416

    PubMed  CAS  Google Scholar 

  16. Nindl I, Rindfleisch K, Lotz B, Schneider A, Durst M (1999) Uniform distribution of HPV 16 E6 and E7 variants in patients with normal histology, cervical intra-epithelial neoplasia and cervical cancer. Int J Cancer 82: 203–207

    Article  PubMed  CAS  Google Scholar 

  17. Nobbenhuis MAE, Walboomers JMM, Helmerhorst TJM, Rozendaal L, Remmink AJ, Risse EKJ, van der Linden HC, Voorhorst F J, Kenemans P, Meijer CJLM (1999) Relation of human papillomavirus status to cervical lesions and consequences for cervical-cancer screening: a prospective study. Lancet 354: 20–25

    Article  PubMed  CAS  Google Scholar 

  18. Peyton CL, Schiffman M, Lörincz AT, Hunt WC, Mielzynska I, Bratti C, Eaton S, Hildesheim A, Morea LA, Rodriguez AC, Herrero R, Sherman ME, Wheeler CM (1998) Comparison of PCR-and Hybrid Capture-Based Human Papillomavirus Detection Systems Using Multiple Cervical Specimen Collection Strategies. J Clin Microbiol 36: 3248–3254

    PubMed  CAS  Google Scholar 

  19. Ratnam S, Franco EL, Ferenczy A (2000) Human papillomavirus testing for primary screening of cervical cancer precursors. Cancer Epidemiol Biomarkers Prev 9: 945–951

    PubMed  CAS  Google Scholar 

  20. Schneider A, Hoyer H, Lotz B, Leistritz S, Kühne-Heid R, Nindl I, Müller B, Haerting J, Dürst M (2000) Screening for high grade cervical intraepithelial neoplasia and cancer by testing for high risk HPV, routine cytology or colposcopy. Int J Cancer 89: 529–534

    Article  PubMed  CAS  Google Scholar 

  21. Schneider A (1994) Natural history of genital papillomavirus infections. Intervirology 37:201–214

    PubMed  CAS  Google Scholar 

  22. Solomon D, Schiffman M, Tarone R (2001) Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial. J Natl Cancer Inst 93: 293–299

    Article  PubMed  CAS  Google Scholar 

  23. Wright-TC J, Denny L, Kuhn L, Pollack A, Lorincz A (2000) HPV DNA testing of self-collected vaginal samples compared with cytologic screening to detect cervical cancer. JAMA 283: 81–86

    Article  PubMed  Google Scholar 

  24. http://www.stressgen.com 2002

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schneider, A., Gissmann, L. (2003). HPV Diagnostik als Voraussetzung zu neuen Präventions-und Therapiekonzepten beim Zervixkarzinom. In: Bender, H.G., Dall, P. (eds) 54. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18257-0_27

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18257-0_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62125-3

  • Online ISBN: 978-3-642-18257-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics