Skip to main content
SpringerLink
Log in

CD7+ and CD56+ Acute Myelogenous Leukemia is a Distinct Biologic and Clinical Disease Entity

  • Conference paper
Acute Leukemias VIII

Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 40))

  • 107 Accesses

Abstract

The rapid progress of diagnostic tools contributes to better understanding of biology and management of acute myelogenous leukemia. Some reports described a high incidence of extramedullary manifestation and a significant shorter survival in patients (pts.) with CD7+ and CD56+ co-expression of AML-blasts. Thus, retrospectively 12 cases of myeloid/natural killer cell precursor phenotype AML diagnosed between 7/95-3/98 were analysed (5 men and 7 women varying from 30 to 85 years of age, median 57,9 years). Extramedullary involvement was evident at initial presenting in 4 cases (one pts. sulcus coronaris penis, three involvement of CNS). Six of the pts. had a high leukocytes concentration (> 30 Gpt/1). At time of presentation the majority (11 pts.) of pts. had circulating blasts. According to the FAB classification 5 cases were classified as FAB M0 or Ml. Expression of CD13/CD33/ CD38/CD56/CD7 and HLA-DR without other NK-, T-cell and B-cell marker as well as MPO+/LF- was observed. Five out of the 12 pts. presented a germline configuration of the T-cell receptor β, γ, δ, and Ig heavy chain and Ig k gene by Southern blotting. Only five pts. were successfully treated with aggressive induction chemotherapy (cytarabine and anthracycline) and achieved complete or partial remission, whereas 7 pts. were refractory to induction chemotherapy. Median overall survival for the group was 4,5 month. The data presented suggest that the myeloid/natural killer cell precursor phenotype AML constitute a distinct biologic and clinical disease entity with worse clinical prognosis. It seems to be important to distinguish CD7/CD56 positive AML from other subtypes for the development of novel therapeutic approaches for this entity.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Baer MR, Stewart CC, Lawrence D, Arthur DC, Mrozek K, Strout MP, Davey FR, Schiffer CA, Bloomfield CD (1998) Acute myeloid leukemia with 11q23 translocations: myelomonocytic immunophenotype by multiparameter flow cytometry. Leukemia 12(3), 317–325

    Article  PubMed  CAS  Google Scholar 

  2. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick M, Sultan C (1985) Proposed revised criteria for the classification of the acute leukemia: a report of the French-American-British group. Ann Intern Med 103:626–629

    Google Scholar 

  3. Bradstock KF, Kirk J, Grimsey PG, Karbral A, Hughes WG (1989). Unusual immunophenotypes in acute leukemias: Incidence and clinical correlations. Br J Haematol 72: 512–518

    Article  PubMed  CAS  Google Scholar 

  4. Breit TM, Wolvers-Tettero IL, Beishuizen A, Verhoeven MA, van Wering ER, van Dongen JJ 1993 Southern blot patterns, frequencies, and junctional diversity of T-cell receptor-delta gene rearrangements in acute lymphoblastic leukemia. Blood 82: 3063–3074

    Google Scholar 

  5. Byrd JC, Edenfield WJ, Shields DJ, Dawson NA (1995). Extramedullary meyloid cell tumors in acute nonlymphocytic leukemia: A clinical review. J Clin Oncol 13:1800–1816

    PubMed  CAS  Google Scholar 

  6. Cadwell FJ, Burns P, Dick FR, Jones MP, Heckman KD, Weiner GJ, Goeken JA (1993) Minimally differentiated acute leukemia. Leuk Res 17: 199–208

    Article  PubMed  CAS  Google Scholar 

  7. Gale RP, Bassat IB (1988) Hybride acute leukemia. Br J Haematol 65: 261–264

    Google Scholar 

  8. Hatano Y, Miura I, Horiuchi T, Hoshi N, Nanjou, Masuda H, Miura AB (1997) Cerebellar myeloblastoma formation in CD7-positive, neural cell adhesion molecule (CD56)-positive acute myelogenous leukemia (Ml). Ann Hematol 75:125–128

    Article  PubMed  CAS  Google Scholar 

  9. Hieter PA, Minzel JV, Leder P (1982) Evolution of human immunoglobulin k J region genes. J Biol Chem 257: 1516–1522

    PubMed  CAS  Google Scholar 

  10. Iizuka Y, Aiso M, Kanemaru M, Kawamura M, Takeuchi J, Horikoshi A, Ohsima T, Mizoguchi H, Horie T (1992) Myeloblastoma formation in acute myeloid leukemia. Leuk Res 16: 665–671

    Article  PubMed  CAS  Google Scholar 

  11. Jennings CD, Foon KA. Recent advances in Flow Cytometry (1997) Application to the diagnostis of hematologic malignancy. Blood 90: 2863–2892

    PubMed  CAS  Google Scholar 

  12. Kern WF, Spier CM, Hannemann EH, Miller TP, Matzner M, Grogan TM. Neural cell adhesion molecule-positive peripheral T-cell lymphoma (1992) A rare variant with a propensitiy for unusual sides of involvement. Blood 79: 2432–2437

    PubMed  CAS  Google Scholar 

  13. Kita K, Miwa H, Nakase K, Kawakami K, Kobayashi T, Shirakawa S, Tanaka I, Ohta C, Tsutani H, Oguma S, Kyo T, Dohy H, Kamada N, Nasu K, Uchino H (1993) Clinical importance of CD7 expression in acute myelogenous leukemia. Blood 81:2399–2405

    PubMed  CAS  Google Scholar 

  14. Knapp W, Majdic O, Strobl H. Flow cytometric analysis of intracellular myeloperoxidase and lactoferrin in leukemia diagnosis. In: Recent Advances in Cell Biology of Acute Leukemia—Impact on Clinical Diagnosis and Therapy. Ludwig WD, Thiel E eds. Recent Results in Cancer Research, Springer Verlag Berlin Heidelberg; 131: 31–40

    Google Scholar 

  15. Kurtzberg J, Waldmann TA, Davey MP, Bigner SH, Moore JO, Hershfield MS, Haynes BF (1989) CD7+, CD4-, CD8-acute leukemia: A syndrome of malignant pluripotent lymphohematopoetic cells. Blood 73:381–390

    PubMed  CAS  Google Scholar 

  16. Lo-Coco F, De Rossi G, Pasqualetti D, Lopez M, Diverio D, Latagliata R, Fenu S, Mangelli F (1989) CD7-positive acute myelogenous leukemia: a subtype associated with cell immaturity. Br J Haematol 73: 480–485

    Article  PubMed  CAS  Google Scholar 

  17. Loughran TP (1993) Clonal disease of large granular lymphocytes. Blood 82: 1–14

    PubMed  Google Scholar 

  18. Reust-Borst MA, Steinke B, Waller HD, Buhring HJ, Muller CA (1992) Phenotypic and clinical heterogeneity of CD56-positive acute-non-lymphoblastic leukemia. Ann Hematol 64: 78–82

    Article  Google Scholar 

  19. Scott AA, Head DR, Kopecky KJ, Appelbaum FR, Theil KS, Grever MR, Whittaker MH, Griffith BB, Licht JD, Grogan TM, Willmann CL (1994) HLA-DR-, CD33+, CD56+, CD 16-myeloid/natural killer cell acute leukemia: A previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood 84: 244–255

    PubMed  CAS  Google Scholar 

  20. Second MIC Cooperative Study Group (1988) Morphologic, immunologic and cytogenetic (MIC) working classification of the acute myelogenous leukemias. Cancer Gen Cytogen 30:1–15

    Article  Google Scholar 

  21. Seymour JF, Pierce SA, Kantarjian HM, Keating MJ, Estey EH (1993) Neural cell adhesion molecule (CD56) is associated with FAB subtyp, cytogenetic and skin infiltration in acute myelogenous leukemia (AML). Blood 82(suppl.l), 126a

    Google Scholar 

  22. Seymour JF, Pierce SA, Kantarjian HM, Keating MJ, Estey EH (1994) Investigation of karyotypic, morphological and clinical features in patients with Acute Myeloid Leukemia blast cells expressing the neural cell adhesion molecule (CD56). Leukemia 8: 823–826

    PubMed  CAS  Google Scholar 

  23. Suzuki R, Yamamoto K, Seto M, Kagami Y, Ogura M, Yatabe Y, Suchi T, Kodera Y, Morishima Y, Takahashi T, Saito H, Ueda R, Nakamura S (1997) CD7+ and CD56+ myeloid/natural killer cell precursor acute leukemia: A distinct hematolymphoid disease entity. Blood 90: 2417–2427

    PubMed  CAS  Google Scholar 

  24. Takahashi N, Nakai S, Honjo T (1980) Cloning of human immunoglobulin u gene and comparison with mouse μ gene. Nucl Acids Res 8: 5983–5991

    Article  PubMed  CAS  Google Scholar 

  25. Thomas X, Vila L, Campos L, Sabido O, Archimbaud E (1995) Expression of N-CAM (CD56) on acute leukemia cells: Relationship with disease characteristics and outcome. Leuk Lymph 19: 295–300

    Article  CAS  Google Scholar 

  26. Vendetti A, Poetea GD, Stasi R, Buccisano F, Aronica G, Bruno A, Cox C, Maffei L, Tamburini A, Papa G, Amadori (1996) Biological profile of 23 cases of minimally differntiated acute myeloid leukemia (AML-M0) and its clinical implications. Blood 87: 418–420 (letter)

    Google Scholar 

  27. Vidriales MB, Orfano A, Gonzales M, Hernandez JM, Lopez-Berges MC, Garcia MA, Canizo MC, Cabarello MD, Macedo A, Landolfi C (1993) Expression of NK and lymphoid-associated antigens in blast cells of acute myeloblastic leukemia. Leukemia 7: 2026–2029.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Hematology/Oncology, Department of Medicine, Otto-von-Guericke-University of Magdeburg, Germany

    C. Kahl, A. Florschütz, S. Leuner, K. Jentsch-Ullrich, A. Franke & H.-G. Höffkes

  2. Institute of Humangenetics, University of Heidelberg, Germany

    C. R. Bartram

Authors
  1. C. Kahl
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Florschütz
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Leuner
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. Jentsch-Ullrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. A. Franke
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. C. R. Bartram
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. H.-G. Höffkes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Internal Medicine A, Germany

    T. Büchner

  2. Department of Internal Medicine III, University Hospital Großhadern Ludwig-Maximilians-University, Marchioninistr. 15, 81377, München, Germany

    W. Hiddemann

  3. Dept. of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    B. Wörmann

  4. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    G. Schellong , J. Ritter  & U. Creutzig ,  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kahl, C. et al. (2001). CD7+ and CD56+ Acute Myelogenous Leukemia is a Distinct Biologic and Clinical Disease Entity. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18156-6_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62109-3

  • Online ISBN: 978-3-642-18156-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation