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Acute Leukemias VIII pp 72–77Cite as

CD10 Expression in T-Lineage Adult Acute Lymphoblastic Leukemia

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 40))

Abstract

Fifty-five adult patients with newly diagnosed T-lineage acute lymphoblastic leukemia (ALL) were analysed for CD10 expression on leukemic cells. CD10 was expressed on 18/55 (33%) cases. There were no differences between CD10+ and CD10- cases in clinical features or karyotypic patterns, except for white blood cell (WBC) counts that were higher in CD10+ patients. CD10 positivity was significantly associated with the expression of CD1 (p = 0.0001), and tend to be associated with that of CD4 and CD8. CD10 negativity tend to be associated with CD34 expression. After intensive induction chemotherapy according to LALA protocols, 50 of the 55 patients (91%, 95% confidence interval [CI]: 80-97%) achieved a complete remission (CR). The median disease-free survival (DFS) and the median overall survival were 26 and 36 months respectively with 2-year survival rates of 40% and 47%. Relapse was observed in 21 cases (42% of patients achieving CR). Despite better results in CD10+ cases, no statistical differences were seen between CD10+ and CD10- patients in terms of CR rates, DFS and overall survival. We conclude that this lack of statistical difference could be related to the use of adapted therapy involving cytarabine and cyclophosphamide. However, a trend for a better outcome in CD10+ patients warrants a more intensive form of therapy in patients with CD10- expression.

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Authors and Affiliations

  1. Service d’Hématologie, Hôpital Edouard Herriot, Lyon, France

    X. Thomas & D. Fière

  2. Laboratoire Central d’Hématologie et de Cytogénétique, Hôpital Edouard Herriot, Lyon, France

    C. Charrin & J.-P. Magaud

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  1. X. Thomas
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  2. C. Charrin
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  3. J.-P. Magaud
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  4. D. Fière
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Editor information

Editors and Affiliations

  1. Department of Internal Medicine A, Germany

    T. Büchner

  2. Department of Internal Medicine III, University Hospital Großhadern Ludwig-Maximilians-University, Marchioninistr. 15, 81377, München, Germany

    W. Hiddemann

  3. Dept. of Internal Medicine, University of Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany

    B. Wörmann

  4. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48149, Münster, Germany

    G. Schellong , J. Ritter  & U. Creutzig ,  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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Thomas, X., Charrin, C., Magaud, JP., Fière, D. (2001). CD10 Expression in T-Lineage Adult Acute Lymphoblastic Leukemia. In: Büchner, T., Hiddemann, W., Wörmann, B., Schellong, G., Ritter, J., Creutzig, U. (eds) Acute Leukemias VIII. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 40. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18156-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-18156-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-62109-3

  • Online ISBN: 978-3-642-18156-6

  • eBook Packages: Springer Book Archive

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