Abstract
Coagulation testing is currently gaining increasing importance in veterinary Medicine. This applies particularly to coagulation factor VIII and its associated diseases [1, 2, 5, 6, 9, 10]. It therefore appeared necessary to examine the Methods currently used for the determination of factor VIII activity with regard to their comparability and suitability for use in animals. The coagulometric and chromogenic assay Methods established for the determination of factor VIII activity in human Medicine were used.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Gentry PA, Feldman BF, O’Neill SL. An evaluation of the effect of the reagent Modification on routine laboratory coagulation tests. Equine Vet J 1992; 24: 30–32
Gopegui RR (ed). Hemostasis. In: Feldman BF, Zinkl JG, Jain NC (eds). Veterinary hematology. Lippincott Baltimore Philadelphia 2000; 517–593
Kasper CK. Laboratory diagnosis of factor VIII inhibitors. In: Kessler C, Garvey MB, Green D, Kasper C, Lusher J (eds). Acquired hemophilia. Excerpta Medica Princetown 1995; 9–23
Langdell RD, Wagner RH, Brinkhous KM. Effect of antihemophilic factor on one-stage clotting tests. J Lab Clin Med 1953; 41: 637–647
Lutze G, Breyer J, Naumann C, Zawta B. Useful facts about coagulation. Roche Diagnostics Mannheim 2000
Lutze G, Lutze GJR, Kutschmann K. Hämophilie A und B beim Hund. J Lab Med 2000; 24: 319–324
Lutze G, Schlote A, Mittler U. Untersuchungen zur Bestimmung des Gerinnungsfaktor VIII-Inhibitors. Z Ges Inn Med 1980; 35: 330–336
Lutze GJR. Untersuchungen zur Wirkung von Gerinnungsfaktor VIII-Inhibitoren bei angeborenem und erworbenem Faktor VIII-Mangel (Hemmkörperhämophilie A und spontane Hämophilie A) auf tierischen Faktor VIII. Otto-von-Guericke-Universität Magdeburg 2000; Inauguraldissertation
Mischke R. Optimization of coagulometric tests that incorporate human plasma for determination of coagulation factor activities in canine plasma. AM J Vet Res 2001; 62: 625–629
Stokol T, Trepanier L, Parry BW, Finnin BC. Pharmacokinetics of von Willebrand factor and factor VIII in canine von-Willebrand disease and haemophilia A. Res Vet Sci 1997; 63: 23–27
Wagenvoord RJ, Hendrix HH, Hemker HC. Development of a simple chromogenic factor VIII assay for clinical use. Haemostasis 1989; 19: 196–204
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Lutze, G., Aumann, V., Lutze, G., Kutschmann, K., Schröpel, M. (2003). Inactivation of Animal Factor VIII by human Factor VIII Inhibitors: Special Methodological Features in Performing the Factor VIII Assay and the Bethesda Assay. In: Scharrer, I., Schramm, W. (eds) 32nd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18150-4_42
Download citation
DOI: https://doi.org/10.1007/978-3-642-18150-4_42
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43884-7
Online ISBN: 978-3-642-18150-4
eBook Packages: Springer Book Archive