Skip to main content
SpringerLink
Log in

Cardiac and cerebral Manifestations of the Antiphospholipid Syndrome

  • Conference paper
32nd Hemophilia Symposium

  • 101 Accesses

Abstract

Arterial or venous thrombosis, fetal loss and thrombocytopenia characterize the clinical trias of the antiphospholipid syndrome (APS) [1]. It has been reported that a history of thrombosis is present in approximately 40–50% of the patients with antiphospholipid (aPL) antibodies and that 70% of the events are venous and 30% are arterial [2]. Deep vein thrombosis and pulmonary embolism are the Most common venous events whereas the cerebral and cardiac system is Most commonly affected on the arterial site [3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Schmidt R, Scheuermann RH, Viertel A, Geiger H, Scharrer I. Antiphospholipid antibody syndrome. med Klin 1999; 94:93–100.

    Article  CAS  Google Scholar 

  2. McNeil HP, Chestermann CN, Krilis SA. IMMunology and clinical importance of antiphospholipid antibodies. Adv IMMunol 1991; 49:193–280.

    Article  PubMed  CAS  Google Scholar 

  3. Laraki R, Bletry 0, Wechsler B, Piette JC, de Zuttere D, Godeau P. The heart and antiphospholipid antibodies. Rev Med Interne 1996; 17:46–57.

    Article  PubMed  CAS  Google Scholar 

  4. AMes PR, Tommasino R, Iannaccone L, Brillante M, Cimino R, Brancaccio V. Coagulation activation and fibrinolytic imbalance in subjects with idiopathic antiphospholipid antibodies — a crucial role for acquired free protein S deficiency. Thromb Haemost 1996; 76:190–4.

    PubMed  CAS  Google Scholar 

  5. Rand JH, Wu XX. Antibody Mediated disruption of the annexin V antithrombotic shield: a new Mechanism for thrombosis in the antiphospholipid syndrome. Thromb haemost 1999; 82:649–55.

    PubMed  CAS  Google Scholar 

  6. Ducceschi V, Sarubbi B, Iacono A. Primary antiphospholipid syndrome and cardiovascular disease. Eur Heart J 1995; 16:441–5.

    PubMed  CAS  Google Scholar 

  7. Takeuchi, Obayashi T, Toyama J. Primary antiphospholipid syndrome with acute Myocardial infarction recanalized by PTCA. Heart 1998; 79:96–8.

    PubMed  CAS  Google Scholar 

  8. Asherson RA, Khamashta MA, Ordi-Ros J, Derksen RH, Machin SJ, Barquinero J, Outt HH, Harris EN, Vilardell-Torres M, Hughes GR. The »primary« antiphospholipid syndrome: Major clinical and serological features. medicine (Baltimore) 1989; 68:366–74.

    CAS  Google Scholar 

  9. Galve E, Ordi J, Barquinero J, Evangelista A, Vilardell M, Soler-Soler J. Valvular heart disease in the primary antiphospholipid syndrome. Ann Intern Med 1992; 116: 293–8.

    PubMed  CAS  Google Scholar 

  10. Garcia-Torres R, AMigo MC, de la Rosa A, Moron A, Reyes PA. Valvular heart disease in primary antiphospholipid syndrome: clinical and Morphological findings. Lupus 1996; 5: 56–61.

    PubMed  CAS  Google Scholar 

  11. Levine SR, Brey RL. Neurological aspects of antiphospholipid antibody syndrome. Lupus 1996; 5: 347–53.

    PubMed  CAS  Google Scholar 

  12. Kenet G, Sadetzki S, Murad H, Martinowitz U, Rosenberg N, Gitel S, Rechavi G, Inbal A. Factor V Leiden and antiphospholipid antibodies are significant risk factors for ischemic stroke in children. Stroke 2000; 31:1283–8.

    Article  PubMed  CAS  Google Scholar 

  13. Levine SR, Brey RL, Sawaya KL, Salowich-Palm L, Kokkinos J, Kostrzema B, Perry M, Havstad S, Carey J. Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. Ann Neurol 1995; 38: 119–24.

    Article  PubMed  CAS  Google Scholar 

  14. Asherson RA, Mercey D, Phillips G, Sheehan N, Gharavi AE, Harris EN, Hughes GR. Recurrent stroke and Multi-infarct dementia in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 1987; 46: 605–11.

    Article  PubMed  CAS  Google Scholar 

  15. Christopher R, Nagaraja D, Dixit NS, Narayanan CP. Anticardiolipin antibodies: a study in cerebral vein thrombosis. Acta Neurol Scand 1999; 99: 121–4.

    Article  PubMed  CAS  Google Scholar 

  16. Asherson RA, Piette JC. The catastrophic antiphospholipid syndrome: acute Multiorgan failure associated with antiphospholipid antibodies: a review of 31 patients. Lupus 1996; 5: 414–7.

    PubMed  CAS  Google Scholar 

  17. Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulans: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardization Committee of the ISTH. Thromb Haemost. 1995;74: 1185–90.

    PubMed  CAS  Google Scholar 

  18. Hamsten A, Norberg R, Bjorholm M, de Faire U, Holm G. Antibodies to cardiolipin in young survivors of Myocardial infarction: an association with recurrent cardiovascular events. Lancet 1986; 1:113–6.

    Article  PubMed  CAS  Google Scholar 

  19. Vaarala O, Manttari M, Manninen V, Tenkanen L, Puurunen M, Aho K, Palpsuo T. Anti-cardiolipin antibodies and risk of Myocardial infarction in a prospective cohort of Middleaged Men. Circulation 1995; 91:23–7.

    Article  PubMed  CAS  Google Scholar 

  20. Kattwinkel N, Villanueva AG, Labib SB, Aretz HT, Walek JW, Burns DL, Klenz JT. Myocardial infarction caused by cardiac Microvasculopathy in a patient with the primary antiphospholipid syndrome. Ann Intern Med 1992; 116:974–6.

    PubMed  CAS  Google Scholar 

  21. Nihoyannopoulos P, Gomez PM, Joshi J, Loizou S, Walport MJ, Oakley CM. Cardiac abnormalities in systemic lupus erythematosus. Association with raised anticardiolipin antibodies Circulation 1990; 82:369–75.

    CAS  Google Scholar 

  22. Galve E, Candell-Riera J, Permanyer-Miralda G, Vilardell M, Soler-Soler J. Valvular heart disease in systemic lupus erythematosus. N Engl J Med 1989; 320: K739–41.

    Google Scholar 

  23. Galve E OJ, Candell-Riera J, Piegrau C, Permanyer-Miralda G, Garcia-Del-Castillo H, Soler-Soler J. Prevalence, Morphological types and evolution of cardiac valvular disease in systemic lupus erythematosus. N Engl J Med 1988; 319:817–23.

    Article  PubMed  CAS  Google Scholar 

  24. Nesher G, Ilany J, Rosenmann D, Abraham AS. Valvular dysfunction in antiphospholipid syndrome: prevalence, clinical features and treatment. Semin Arthritis Rheum 1997; 27:27–53.

    Article  PubMed  CAS  Google Scholar 

  25. Harris EN, Gharavi AE, Asherson RA, Boey ML, Hughes GR. Cerebral infarction in systemic lupus: association with anticardiolipin antibodies. Clin Exp Rheumatol 1984; 2:47–51.

    PubMed  CAS  Google Scholar 

  26. Barbut D, Borer JS, Wallerson D, AMeisen O, Lockshin M. Anticardiolipin antibody and stroke: possible relation of valvular heart disease and embolic events. Cardiology 1991; 79:99–109.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. Miesbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. F. Jung
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Th. Vigh
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. Scharrer
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Inge Scharrer

  2. Dept. of Hemostasiology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    Wolfgang Schramm

Rights and permissions

Reprints and permissions

Copyright information

© 2003 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Miesbach, W., Jung, F., Vigh, T., Scharrer, I. (2003). Cardiac and cerebral Manifestations of the Antiphospholipid Syndrome. In: Scharrer, I., Schramm, W. (eds) 32nd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18150-4_41

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-18150-4_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43884-7

  • Online ISBN: 978-3-642-18150-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation