Abstract
Newborns have despite of low clotting factors and an in vitro poor platelet function a good functioning hemostasis. The reason for that is still not completely clear. Platelet counts of healthy neonates are similar to those of normal adults, but their platelets react hyporesponsively to a variety of physiological agonists, resulting in decreased platelet activation and aggregation [1–4].
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References
Andrew M., Paes B., Miller R., Johnston M., Mitchell L., Tollefsen DM., Powers P., Development of the human coagulation system in the full-term infant. Blood, 1987; 70: 165–72.
Corrigan JJ. (1989) Neonatal coagulation disorders. In: Alter BP (ed). Perinatal hematology. Churchill Livingstone, New York, pp 165–193.
Hathaway WE., (1987) Haemostatic disorders in the newborn. In: Bloom AL, Thomas DP., (eds) Haemostasis and thrombosis. Churchill Livingstone, Edinburgh, pp 554–569.
Israels SJ., Daniels M., McMillan EM. Deficient collagen-induced activation in the newborn platelet. Pediatr Res, 1990; 27: 337–43.
Stuart MCA., Bevers EM., Comfurius P., Zwaal RFA., Reutelingsperger CPM., Frederik PM. Ultrastructural detection of surface exposed phosphatidylserine on activated blood platelets. Thromb. Haemost, 1995,74(4): 1145–51.
Andrew M, Vegh P, Johnston M, Bowker J, Ofosu F, Mitchell L: Maturation of the hemostatic system during childhood. Blood, 1992; 8:1998–2005.
Andrew M, Castle V, Mitchell L, Paes B. Modified bleeding time in the infant. AM J Haematol 1989; 30: 190–1.
Andrew M, Schmidt B, Mitchell L, Paes B, Ofosu F: Thrombin generation in newborn plasma is critically dependent on the concentration of prothrombin. Thromb Haemost 1990,63: 27–30.
Rajasekhar D, Kestin AS, Bednarek F J, et al. Neonatal platelets are less reactive than adult platelets to physiological agonists in whole blood. Thromb Haemost 1994; 72: 957–963.
Gelman B, Setty BNY, Chen D, AMin-Hanjani S, Stuart MJ. IMpaired Mobilization of intracellular calcium in neonatal platelets. Pediatr Res, 1996; 39: 692–696.
Bevers EM, Tilly RHJ, Senden JMG, Comfurius P, Zwaal RFA. Exposure of endogenous phosphatidylserine at the outer surface of stimulated platelets is reversed by restoration of aminophospholipid translocase activity. Biochemistry, 1989; 28: 2382–2387.
Bevers EM, Comfurius P, Van Rijn JLML, Hemker HC, Zwaal RFA. Eur. J. Biochem. 1982; 122: 429–436
Pressman BC: Properties of ionophores with broad range of cation selectivity. Fed Proc 32: 1698–1703, 1973
Hamill RL, Gorman M, Gale RM, Higgins CE, Hoehn MM. A23187, a new ionophor for divalent cations. I. Discovery, isolation and properties. Twelfth Interscience Conference on Antimicrobial Agents and Chemotherapy. 1972, p 32 (Abstr).
Reed PW, Lardy HA: A23187: a divalent cation ionophor. J Biol Chem. 1972; 247: 6970–6973.
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Petritsch, M., Cvirn, G., Leschnik, B., Köstenberger, M., Muntean, W. (2003). Influence of Phospholipids of the Platelet Membrane of Newborns on the Thrombin Generation. In: Scharrer, I., Schramm, W. (eds) 32nd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18150-4_35
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DOI: https://doi.org/10.1007/978-3-642-18150-4_35
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