Abstract
Despite of low concentrations of clotting factors, newborns have an excellent hemostasis. Neonates have good wound heeling and show no increased bleeding during surgery. Thus, it was the aim of our study to investigate whether low concentrations of the anticoagulatory proteins tissue factor pathway inhibitor (TFPI) and antithrombin (AT) compensate for low levels of procoagulatory proteins. In contrast to the routine determinations of clotting parameter, clotting was initiated by applying low concentrations of lipidated tissue factor (TF).
This study was supported by a grant from the »Gesellschaft zur Förderung der Gesundheit des Kindes (INVITA)«.
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Cvirn, G., Gallistl, S., Leschnik, B., Giradi, L., Muntean, W. (2003). Effects of Tissue Factor Pathway Inhibitor and Antithrombin on Thrombin Generation in Tissue Factor-activated Cord Plasma. In: Scharrer, I., Schramm, W. (eds) 32nd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18150-4_18
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DOI: https://doi.org/10.1007/978-3-642-18150-4_18
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