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32nd Hemophilia Symposium pp 103–110Cite as

First thromboembolic Onset in Children carrying either the heterozygeous Factor V G1691A Mutation or the Prothrombin G20210A Variant

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Abstract

Disorders of the hemostatic system are Major causes of thrombophilia in adults. Various genetic defects in the regulation of blood coagulation and fibrinolysis predispose to thromboembolic events [1–5]. The factor V (FV) G1691A Mutation and the prothrombin (Fil) G20210A variant appear to be relevant not only in adult thromboembolism. However, due to the low incidence of thromboembolic events in childhood, the role of hereditary prothrombotic risk factors is still a Matter of discussion [6–12]. There is still a lack of data concerning the exogenous triggering factors associated with a first thromboembolic event. Furthermore, a significantly higher incidence of thrombosis — especially renal venous thrombosis — in Male neonates and infants compared to females has been described [13–15]. Therefore, a possible impact of age and gender on thromboembolic Manifestations in pediatric patients is of interest.

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Authors
  1. A. Kosch
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  2. S. Becker
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  3. K. Kurnik
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  4. K. Sudbrak
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  5. R. Schobess
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  6. R. Junker
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  7. M. Käse
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  8. U. Nowak-Göttl
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Editor information

Editors and Affiliations

  1. Hemophilia Center, Dept. of Internal Medicine, University Hospital, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Inge Scharrer

  2. Dept. of Hemostasiology, University Hospital, Ziemssenstr. 1a, D-80336, München, Germany

    Wolfgang Schramm

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© 2003 Springer-Verlag Berlin Heidelberg

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Kosch, A. et al. (2003). First thromboembolic Onset in Children carrying either the heterozygeous Factor V G1691A Mutation or the Prothrombin G20210A Variant. In: Scharrer, I., Schramm, W. (eds) 32nd Hemophilia Symposium. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18150-4_13

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  • DOI: https://doi.org/10.1007/978-3-642-18150-4_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43884-7

  • Online ISBN: 978-3-642-18150-4

  • eBook Packages: Springer Book Archive

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