Abstract
Treatment of the proximal stump of transected rat facial nerve with antibodies against NGF, BDNF, bFGF, IGF-I, CNTF, or GDNF increased the precision of reinnervation, as evaluated by multiple retrograde labeling of motoneurons, more than two times as compared to control animals. However, biometric analysis of vibrissae movements did not show positive effects on functional recovery suggesting that polyneuronal reinnervation of muscles – rather than collateral branching – may be the critical limiting factor for restoration of function.
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© 2011 Springer-Verlag Berlin Heidelberg
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Angelov, D.N. (2011). Conclusions. In: Physical Rehabilitation of Paralysed Facial Muscles: Functional and Morphological Correlates. Advances in Anatomy, Embryology and Cell Biology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18120-7_4
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DOI: https://doi.org/10.1007/978-3-642-18120-7_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-18119-1
Online ISBN: 978-3-642-18120-7
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