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Environmental Studies as a Tool for Detecting Epigenetic Mechanisms in Schizophrenia

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Brain, Behavior and Epigenetics

Part of the book series: Epigenetics and Human Health ((EHH))

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Abstract

Epigenetic mechanisms may play an important role in the etiological pathways of schizophrenia. Since the epigenetic status of the genome partly depends on environmental factors in pre- and postnatal environments, exposure to such factors should be taken into account in epigenetic studies of schizophrenia. Prenatal famine and childhood ethnic minority status have been identified as environmental risk factors for schizophrenia. These exposures can be used to investigate epigenetic effects on schizophrenia, since environmental exposure can be measured with sufficient precision, homogeneously exposed populations are available for study, and plausible biological pathways have been suggested (albeit less specific for migration). This chapter shows that epidemiological studies of famine and migration can help to detect epigenetic mechanisms in schizophrenia, by comparing the epigenome of exposed and unexposed schizophrenia cases and controls. The results of the comparisons will be different depending on the mechanism involved in the interplay between environment and epigenome. If these epidemiological designs are not applied, the overall result of epigenetic schizophrenia studies may well continue to be inconclusive.

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Authors and Affiliations

  1. Parnassia Center for Early Psychosis, Lijnbaan 4, 2512 VA, The Hague, The Netherlands

    Wim Veling

  2. Department of Epidemiology, Columbia University, Mailman School of Public Health, 722 West 168 Street, New York, NY, 10032, USA

    L. H. Lumey & Ezra Susser

  3. Department of Molecular Epidemiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands

    Bas Heijmans

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  1. Wim Veling
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  2. L. H. Lumey
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  3. Bas Heijmans
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  4. Ezra Susser
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Correspondence to Ezra Susser .

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Editors and Affiliations

  1. , The Krembil Family Epigenetics Laborator, Centre for Addiction and Mental Health, College Street 250, Toronto, M5T 1R8, Ontario, Canada

    Arturas Petronis

  2. , Institute of Psychiatry, King's College London, De Crispigny Park, London, SE5 8AF, United Kingdom

    Jonathan Mill

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Veling, W., Lumey, L.H., Heijmans, B., Susser, E. (2011). Environmental Studies as a Tool for Detecting Epigenetic Mechanisms in Schizophrenia. In: Petronis, A., Mill, J. (eds) Brain, Behavior and Epigenetics. Epigenetics and Human Health. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17426-1_6

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