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Overcoming Insulin Resistance with Ciliary Neurotrophic Factor

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Diabetes - Perspectives in Drug Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 203))

Abstract

The incidence of obesity and related co-morbidities such as insulin resistance, dyslipidemia and hypertension are increasing at an alarming rate worldwide. Current interventions seem ineffective to halt this progression. With the failure of leptin as an anti-obesity therapeutic, ciliary neurotrophic factor (CNTF) has proven efficacious in models of obesity and leptin resistance, where leptin proved ineffective. CNTF is a gp130 ligand that has been found to act centrally and peripherally to promote weight loss and insulin sensitivity in both human and rodent models. Future research into novel gp130 ligands may offer new candidates for obesity-related drug therapy.

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Acknowledgements

The authors wish to thank Hi Le for assistance in producing this manuscript, the support of the National Health and Medical Research Council (NHMRC), the Australian Research Council and the Diabetes Australia Research Trust. VBM is supported in part by a Baker IDI Heart and Diabetes Institute Early Career Scientist Grant. MAF is supported by a Principal Research Fellowship from the NHMRC.

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  1. Cellular and Molecular Metabolism Laboratory, Baker IDI Heart and Diabetes Institute, 6492, St Kilda Road Central, Melbourne, 8008, VIC, Australia

    Tamara L. Allen, Vance B. Matthews & Mark A. Febbraio

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  1. Tamara L. Allen
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  2. Vance B. Matthews
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  3. Mark A. Febbraio
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Correspondence to Mark A. Febbraio .

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  1. Fakultät Lebenswissenschaften Molekulare Pharmakologie und Toxikologie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany

    Mathias Schwanstecher

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Allen, T.L., Matthews, V.B., Febbraio, M.A. (2011). Overcoming Insulin Resistance with Ciliary Neurotrophic Factor. In: Schwanstecher, M. (eds) Diabetes - Perspectives in Drug Therapy. Handbook of Experimental Pharmacology, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17214-4_9

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