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Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes

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Book cover Diabetes - Perspectives in Drug Therapy

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 203))

Abstract

Interleukin-1β (IL-1β) is a key regulator of the body’s inflammatory response and is produced after infection, injury, and an antigenic challenge. Cloned in 1984, the single polypeptide IL-1β has been shown to exert numerous biological effects. It plays a role in various diseases, including autoimmune diseases such as rheumatoid arthritis, inflammatory bowel diseases, and Type 1 diabetes, as well as in diseases associated with metabolic syndrome such as atherosclerosis, chronic heart failure, and Type 2 diabetes. The macrophage is the primary source of IL-1β, but epidermal, epithelial, lymphoid, and vascular tissues also synthesize IL-1. Recently, IL-1β production and secretion have also been reported from pancreatic islets. Insulin-producing β-cells within the pancreatic islets are specifically prone to IL-β-induced destruction and loss of function. Macrophage-derived IL-1β production in insulin-sensitive organs leads to the progression of inflammation and induction of insulin resistance in obesity. This chapter explains the mechanisms involved in the inflammatory response during diabetes progression with specific attention to the IL-1β signal effects influencing insulin action and insulin secretion . We highlight recent clinical studies, rodent and in vitro experiments with isolated islets using IL-1β as a potential target for the therapy of Type 2 diabetes.

The online version of the erratum chapter can be found under DOI http://dx.doi.org/10.1007/978-3-642-17214-4_16

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Acknowledgments

This work was supported by the German Research Foundation (DFG, Emmy Noether Programm, MA4172/1-1), the Juvenile Diabetes Research Foundation (JDRF 26-2008-861), and the European Foundation for the Study of Diabetes (EFSD)/Merck Sharp & Dohme (MSD) European Studies on Beta Cell Function and Survival. The authors thank the members of the Islet Biology laboratory in Bremen for critical discussion.

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  1. Centre for Biomolecular Interactions Bremen, University of Bremen, Leobener Straße NW2, Room B2080, 330440, 28334, 28359, Bremen, Germany

    Kathrin Maedler & Gitanjali Dharmadhikari

  2. Boehringer-Ingelheim, Cardiometabolic Diseases Research, Biberach, Germany

    Desiree M. Schumann

  3. Hagedorn Research Institute, Gentofte, Denmark

    Joachim Størling

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  1. Kathrin Maedler
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  2. Gitanjali Dharmadhikari
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  3. Desiree M. Schumann
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  4. Joachim Størling
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Correspondence to Kathrin Maedler .

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  1. Fakultät Lebenswissenschaften Molekulare Pharmakologie und Toxikologie, Technische Universität Braunschweig, Beethovenstraße 55, 38106, Braunschweig, Germany

    Mathias Schwanstecher

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Maedler, K., Dharmadhikari, G., Schumann, D.M., Størling, J. (2011). Interleukin-Targeted Therapy for Metabolic Syndrome and Type 2 Diabetes. In: Schwanstecher, M. (eds) Diabetes - Perspectives in Drug Therapy. Handbook of Experimental Pharmacology, vol 203. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-17214-4_11

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