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Chronobiologie des Hormon- und des Immunsystems

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Psychoendokrinologie und Psychoimmunologie

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Zusammenfassung

Die Chronobiologie ist eine Wissenschaft , die erst seit der Mitte des 20. Jahrhunderts existiert und sich mit der Veränderung des Organismus als Funktion der Zeit beschäft igt. Viele dieser Veränderungen sind zyklisch wiederkehrend, weshalb im Zusammenhang mit der Chronobiologie häufig auch von biologischen Rhythmen gesprochen wird. Auf unterschiedlichsten Ebenen des Organismus können diese biologischen Rhythmen beobachten werden, von der Genexpression bis schließlich hin zum Verhalten. Dies mag mit ein Grund sein, weshalb nur selten zuvor ein Wissenschaft sbereich dermaßen interdisziplinär erforscht wurde. In den Anfängen der chronobiologischen Forschung waren insbesondere Verhaltensforscher damit beschäft igt, Sinn und Zweck solcher Rhythmen zu erkunden. Die Chronobiologie weckte zudem das Interesse von Physiologen, Endokrinologen, Immunologen, da schnell spezifische Rhythmen unterschiedlichster Parameter gefunden wurden. In jüngerer Zeit sind Forschungsgruppen aus den Bereichen der Molekularbiologie, den Neurowissenschaft en sowie der Genetik hinzugekommen. Auch bietet die Chronobiologie Stoff für Mathematiker und Neuroinformatiker, die nichts unversucht lassen, um solche Rhythmen in schlüssigen Formeln zu beschreiben oder mittels neuster Technik nachzubilden.

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Literatur

  • Abbruzzese EA, Birchler T, Ehlert U (in Vorbereitung). Psychosocial stress affects the gene expression of the Clock genes hPER1 and hPER2 in humans

    Google Scholar 

  • Antle MC, Foley NC, Foley DK, Silver R (2007) Gates and oscillators II: zeitgebers and the network model of the brain clock. J Biol Rhythms 22: 14–25

    Article  PubMed  Google Scholar 

  • Arjona A, Sarkar DK (2006) The circadian gene mPer2 regulates the daily rhythm of IFN-μ. J Interferon Cytokine Res 26: 645–649

    Article  CAS  PubMed  Google Scholar 

  • Aschoff J (1965) Circadian Rhythms in Man: A self-sustained oscillator with an inherent frequency underlies human 24-hour periodicity. Science 148: 1427–1432

    Article  CAS  PubMed  Google Scholar 

  • Bailey SL, Heitkemper MM (2001) Circadian rhythmicity of cortisol and body temperature: morningness-eveningness effects. Chronobiol Int 18: 249–261

    Article  CAS  PubMed  Google Scholar 

  • Balsalobre A, Brown SA, Marcacci L et al. (2000) Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling. Science 289: 2344–2347

    Article  CAS  PubMed  Google Scholar 

  • Buijs RM, van Eden CG, Concharuk VD, Kalsbeek A (2003) The biological clock tunes the organs oft he body: timing by hormones and the autonomic nervous system. J Endocrinol 177: 17–26

    Article  CAS  PubMed  Google Scholar 

  • Bunney JN, Potkin SG (2008) Circadian abnormalities, molecular clock genes and chonobiological treatments in depression. Br Med Bull 86: 23–32

    Article  CAS  PubMed  Google Scholar 

  • Burioka N, Takata M, Okana Y et al. (2005) Dexamethasone influences human clock gene expression in bronchial epithelium and peripheral blood mononuclear cells in vitro. Chronobiol Int 22: 585–590

    Article  CAS  PubMed  Google Scholar 

  • Czeisler CA, Shanahan TL, Klerman EB et al. (1995) Suppression of melatonin secretion in some blind patients by exposure to bright light. New England Journal of Medicine 332: 6–11

    Article  CAS  PubMed  Google Scholar 

  • Dallmann R, Touma C, Palme R, Albrecht U, Steinlechner S (2006) Impaired daily glucocorticoid rhythm in Per1Brd mice. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 192: 769–775

    Article  CAS  PubMed  Google Scholar 

  • Danilenko K V, Cajochen C, Wirz-Justice A (2003) Is sleep per se a zeitgeber in humans? J Biol Rhythms 18: 170–178

    Article  PubMed  Google Scholar 

  • Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-Olela F, Schibler U (2000) Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 14: 2950–2961

    Article  CAS  PubMed  Google Scholar 

  • Dickmeis T, Lahir, K, Nica G et al. (2007) Glucocorticoid Play a Key Role in Circadian Cell Cycle Rhythms. PLOS Biology 5: 854–864

    Article  CAS  Google Scholar 

  • Duffy JF, Rimmer DW, Czeisler CA (2001) Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase. Behav Neurosci 115: 895–899

    Article  CAS  PubMed  Google Scholar 

  • Duffy JF, Wright KP Jr (2005) Entrainment of the human circadian system by light. J Biol Rhythms 20: 326–338

    Article  PubMed  Google Scholar 

  • Dunlap JC, Loros J, DeCoursey P (eds) (2004) Chronobiology – Biological Timekeeping. Sinauer, Sunderland

    Google Scholar 

  • Frank, Swartz HA, Boland E (2007) Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder. Dialogues Clin Neurosci 9: 325–331

    PubMed  Google Scholar 

  • Freedman MS, Lucas RJ, Soni B, von Schantz M, Munoz M, David-Grey ZK, Foster RG (1999) Non-rod, non-cone ocular photoreceptors regulate the mammalian circadian behaviour. Science 284: 502–504

    Article  CAS  PubMed  Google Scholar 

  • Fu L, Pelicano H, Liu J, Huang P, Lee CC (2002) The circadian gene Period2 plays an important role in tumor suppression and DNA damage responses in vivo. Cell 111: 41– 50

    Article  CAS  PubMed  Google Scholar 

  • Gachon F, Nagoshi E, Brown SA, Rippberger J, Schibler U (2004) The mammalian circadian timing system: from gene expression to physiology. Chromosoma 113: 103– 112

    Article  PubMed  Google Scholar 

  • Granda TG, Liu XH, Smaaland R, Cermakian N, Filipski E, Sassone-Corsi P, Levi F (2004) Circadian regulation of cell cycle and apoptosis proteins in mouse bone marrow and tumor. The FASEB Journal 19: 304–306

    PubMed  Google Scholar 

  • www.ucsd.tv/evolutionmatters/lesson1/study.shtml. Gesehen 24 Aug 2010

  • Kohsaka A, Bass J (2007) A sense of time: how molecular clocks organize metabolism. Trends Endocrinol Metab 18: 4–11

    Article  CAS  PubMed  Google Scholar 

  • Konopka R, Benzer S (1971) Clock mutants of Drosophila melanogaster. Proc Natl Acad Sci U S A 68: 2112–2116

    Article  CAS  PubMed  Google Scholar 

  • Kriegsfeld RJ, Silver R (2006) The regulation of neuroendocrine function: Timing is everything. Horm Behav 49: 557–574

    Article  CAS  PubMed  Google Scholar 

  • Kudielka BM, Bellingrath S, Hellhammer DH (2007) Further support for higher salivary cortisol levels in »morning« compared to »evening« persons. J Psychosom Res 62: 595–596

    Article  PubMed  Google Scholar 

  • Levi F, Schibler U (2007) Circadian rhythms: mechanisms and therapeutic implications. Annu Rev Pharmacol Toxicol 47: 593–628

    Article  CAS  PubMed  Google Scholar 

  • Levi F, Focan C, Karaboue A et al. (2007) Implications of circadian clocks for the rhythmic delivery of cancer therapeutics. Adv Drug Deliv Rev 59: 1015–1035

    Article  CAS  PubMed  Google Scholar 

  • Lewy AJ, Rough J N, Songer JB, Mishra N, Yuhas K, Emens JS (2007) The phase shift hypothesis for the circadian component of winter depression. Dialogues Clin Neurosci 9: 291–299

    PubMed  Google Scholar 

  • Mediavilla MD, Cos S, Sanchez-Barcelo EJ (1999) Melatonin increases p53 and p21WAF1 expression in MCF-5 human breast cancer cells in vitro. Life Sci 65: 415–420

    Article  CAS  PubMed  Google Scholar 

  • Meyer-Bernstein EL, Jetton AE, Matsumoto SI, Markuns JF, Lehman MN, Bittman EL (1999) Effects of suprachiasmatic transplants on circadian rhythms of neuroendocrine function in golden hamsters. Endocrinology 140: 207–218

    Article  CAS  PubMed  Google Scholar 

  • Motzkus D, Albrecht U, Maronde E (2002) The human PER1 gene is inducible by interleukin-6. J Mol Neurosci 18: 105–109

    Article  CAS  PubMed  Google Scholar 

  • Partonen, T., Treutelein J., Alpman A et al. (2007) Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. Ann Med 39: 229–238

    Article  CAS  PubMed  Google Scholar 

  • Ralph MR, Foster RG, Davis FC, Menaker M (1990) Transplanted suprachiasmatic nucleus determines circadian period. Science 247: 975–978

    Article  CAS  PubMed  Google Scholar 

  • Rajaratnam SMW, Arendt J (2001) Health in a 24 hour society. Lancet 358: 999–1005

    Article  CAS  PubMed  Google Scholar 

  • Rimmer DW, Boivin DB, Shanahan TL, Kronauer RE, Duffy JF, Czeisler CA (2000) Dynamic resetting of the human circadian pacemaker by intermittent bright light. Am J Physiol Regul Integr Comp Physiol 279: R1574–1579

    CAS  PubMed  Google Scholar 

  • Roenneberg T, Merrow M (2002) Light reception: discovering the clock-eye in mammals. Curr Biol 12: R163–165

    Article  CAS  PubMed  Google Scholar 

  • Roenneberg T, Kuehnle T, Pramstaller PP, Ricken J, Havel M, Guth A, Merrow M (2004) A Marker fort he end of adolescence. Curr Biol 14: R1038–1039

    Article  CAS  PubMed  Google Scholar 

  • Roenneberg T, Kuehnle T, Juda M, Kantermann T, Allebrandt K, Gordijn M, Merrow M (2007) Epidemiology of the human circadian clock. Sleep Med Rev 11: 429–438

    Article  PubMed  Google Scholar 

  • Schernhammer ES, Laden F, Speizer FE, Willet, WC, Hunter DJ, Kawachi I, Colditz GA (2001) Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst 93: 1563–1568

    Article  CAS  PubMed  Google Scholar 

  • Smolensky MH (2001) Circadian Rhythms in Medicine. CNS Spectrum 6: 467–482

    CAS  Google Scholar 

  • Spork P (2005) Chronobiologie – Leben mit der Zeit. Rowohlt, Hamburg

    Google Scholar 

  • Stevens RG (2005) Circadian Disruption and Breast Cancer, From Melatonin to Clock Genes. Epidemiology 16: 254– 258

    Article  PubMed  Google Scholar 

  • Takahashi S, Yokota SI, Hara R, Kobayashi T, Akiyama M, Moriya T, Shibata S (2001) Physical and Inflammatory Stressors Elevate circadian Clock Gene mPer1 mRNA Levels in the Paraventricular Nucleus of the Mouse. Endocrinology 142: 4910–4917

    Article  CAS  PubMed  Google Scholar 

  • Vink JM, Groot AS, Kerkhof GA, Boomsma DI (2001) Genetic analysis of morningness and eveningness. Chronobiol Int 18: 809–822

    Article  CAS  PubMed  Google Scholar 

  • Vitaterna MH, Takahashi JS, Turek FW (2001) Overview of circadian rhythms. Alcohol Res Health 25: 85–93

    CAS  PubMed  Google Scholar 

  • Wirz-Justice A (2006) Biological rhythm disturbances in mood disorders. Int Clin Psychopharmacol 21: 11–15

    Article  Google Scholar 

  • Wright KP Jr, Hughes RJ, Kronauer RE, Dijk DJ, Czeisler CA (2001) Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans. Proc Natl Acad Sci U S A 98: 14027–14032

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto T, Nakahata Y, Tanaka M et al. (2005) Acute physical stress elevates mouse period1 mRNA expression in mouse peripheral tissues via a glucocorticoid-responsive element. J Biol Chem 280: 42036–42043

    Article  CAS  PubMed  Google Scholar 

  • Zeitzer JM, Dijk DJ, Kronauer R, Brown E, Czeisler C (2000) Sensitivity of the human circadian pacemaker to nocturnal light: melatonin phase resetting and suppression. J Physiol 526: 695–702

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Zheng T, Stevens RG, Zhang Y, Boyle P (2006) Does »clock« matter in prostate cancer? Cancer Epidemiol Biomarkers Prev 15: 3–5

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Klinische Psychologie und Psychotherapie, Universität Zürich, Binzmühlestraße14/26, 8050, Zürich, Schweiz

    Dr. des. Elvira Abbruzzese

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  1. Dr. des. Elvira Abbruzzese
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Editors and Affiliations

  1. Klinische Psychologie und Psychotherapie, Psychologisches Institut, Universität Zürich, Binzmühlestraße 14/26, 8050, Zürich, Schweiz

    Ulrike Ehlert

  2. Universitätsklinik für Allgemeine Innere Medizin, Kompetenzbereich für Psychosomatische Medizin, Universitätsspital, Inselspital, 3010, Bern, Schweiz

    Roland von Känel

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Abbruzzese, E. (2011). Chronobiologie des Hormon- und des Immunsystems. In: Ehlert, U., von Känel, R. (eds) Psychoendokrinologie und Psychoimmunologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16964-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-16964-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-16963-2

  • Online ISBN: 978-3-642-16964-9

  • eBook Packages: Medicine (German Language)

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