Skip to main content

Psychoendokrinologie und Psychoimmunologie in der Onkologie

  • Chapter
Psychoendokrinologie und Psychoimmunologie

Zusammenfassung

Die Diagnose und Behandlung einer Krebserkrankung wird von vielen Patienten als belastend erlebt. Ungeachtet dessen unterscheiden sich die Betroffenen im Hinblick auf derartige Herausforderungen erheblich in den in ihnen hervorgerufenen psychologischen Reaktionen sowie in ihrer Fahigkeit, sich davon zu erholen. Neben der Angst vor Rezidiven und Nebenwirkungen einer adjuvanten Th erapie geht die Krebserkrankung oft einher mit der Besorgnis, das Heranwachsen der eigenen Kinder zu versaumen, vorzeitig sterben zu mussen und nur noch wenig Zeit mit dem Lebenspartner verbringen zu konnen. Aber auch um den Verlust von sozialen Bindungen und vertrauten Aktivitaten, sexueller Attraktivitat und Sexualempfinden sorgen sich viele der Krebspatienten. Von Bedeutung ist, dass das wahrend der Behandlung von den Patienten geau.erte Ausma. an Disstress einen Pradiktor fur deren Anpassung an die Krankheit einige Jahre spater darstellen kann. Demzufolge konnen sowohl chronischer Stress als auch eine verminderte Lebensqualitat uber viele Jahre der Krebserkrankung bestehen bleiben.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 119.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Abercrombie HC, Giese-Davis J, Sephton S, Epel ES, Turner-Cobb JM, Spiegel D (2004) Flattened cortisol rhythms in metastatic breast cancer patients. Psychoneuroendocrinology 29: 1082–1092

    Article  CAS  PubMed  Google Scholar 

  • Andersen BL, Farrar WB, Golden-Kreutz D et al. (1998) Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst 90: 30–36

    Article  CAS  PubMed  Google Scholar 

  • Andersen BL, Farrar WB, Golden-Kreutz DM et al. (2004) Psychological, behavioral, and immune changes after a psychological intervention: A clinical trial. J Clin Oncol 22: 3570–3580

    Article  PubMed  Google Scholar 

  • Andersen BL, Farrar WB, Golden-Kreutz D et al. (2007) Distress reduction from a psychological intervention contributes to improved health for cancer patients. Brain Behav Immun 21: 953–961

    Article  PubMed  Google Scholar 

  • Andersen BL, Yang HC, Farrar WB et al. (2008) Psychologic intervention improves survival for breast cancer patients: a randomized clinical trial. Cancer113: 3450–3458

    Article  PubMed  Google Scholar 

  • Antoni MH (2003) Stress management intervention for women with breast cancer. American Psychological Association Press, Washington DC

    Google Scholar 

  • Antoni MH, Schneiderman N, Penedo F (2006a) Behavioral interventions: Immunologic mediators and disease outcomes. In: Ader R, Glaser R, Cohen N, Irwin M (eds), Psychoneuroimmunology (4th Ed) Academic, New York, pp 675–703

    Google Scholar 

  • Antoni MH, Lutgendorf S, Cole S et al. (2006b) The influence of biobehavioral factors on tumor biology, pathways and mechanisms. Nat Rev Cancer 6: 240–248

    Article  CAS  Google Scholar 

  • Antoni MH, Pereira DB, Marion I et al. (2008) Stress management effects on perceived stress and cervical neoplasia in low-income HIV-infected women. J Psychosom Res 65: 389–401

    Article  PubMed  Google Scholar 

  • Antoni MH, Lechner S, Diaz A et al. (2009) Cognitive behavioral stress management effects on psychosocial and physiological adaptation in women undergoing treatment for breast cancer. Brain Behav Immun 23: 580–591

    Article  CAS  PubMed  Google Scholar 

  • Antonova L, Mueller CR (2008) Hydrocortisone down-regulates the tumor suppressor gene BRCA1 in mammary cells: a possible molecular link between stress and breast cancer. Genes Chromosomes Cancer 47: 341–352

    Article  CAS  PubMed  Google Scholar 

  • Baxevanis CN, Reclos GJ, Gritzapis AD, Dedousis GV, Missitzis I, Papamichail M (1993) Elevated prostaglandin e2 production by monocytes is responsible for the depressed levels of natural killer and lymphokine-activated killer cell function in patients with breast cancer. Cancer 72(2): 491–501

    Article  CAS  PubMed  Google Scholar 

  • Ben-Eliyahu S (2003) The promotion of tumor metastasis by surgery and stress: Immunological basis and implications for Psychoneuroimmunology. Brain Behavior Immun 17: 27–38

    Article  Google Scholar 

  • Black PH (2002) Stress and the inflammatory response: a review of neurogenic inflammation. Brain Behav Immun 16: 622–653

    Article  CAS  PubMed  Google Scholar 

  • Blomberg BB, Alvarez JP, Diaz A et al. (2009) Psychosocial adaptation and cellular immunity in breast cancer patients in the weeks after surgery: An exploratory study. J Psychosom Res 67: 369–376

    Article  PubMed  Google Scholar 

  • Bower JE (2007) Cancer-related fatigue: Links with inflammation in cancer patients and survivors. Brain Behav Immun 21: 863–871

    Article  CAS  PubMed  Google Scholar 

  • Bower JE, Ganz PA, Aziz N, Olmstead R, Irwin MR, Cole SW (2007) Inflammatory responses to psychological stress in fatigued breast cancer survivors: Relationship to glucocorticoids. Brain Behav Immun 21: 251–258

    Article  CAS  PubMed  Google Scholar 

  • Capuron L, Dantzer R (2003) Cytokines and depression: The need for a new paradigm. Brain Behav Immun 17(1 Suppl): 119–124

    Article  Google Scholar 

  • Carrico A, Antoni MH (2008) The effects of psychological interventions on neuroendocrine hormone regulation and immune status in HIV-positive persons: A review of randomized controlled trials. Psychosom Med: 70, 575–584

    Article  CAS  Google Scholar 

  • Chrousos GP, Gold PW (1992) The Concepts of Stress and Stress System Disorders. Overview of Physical and Behavioral Homeostasis. J Amer Med Assoc 267(9): 1244– 1252

    Article  CAS  Google Scholar 

  • Chuang LT, Lotzova E, Cook KR, Cristoforoni P, Morris M, Wharton JT (1993) Effect of new investigational drug taxol on oncolytic activity and stimulation of human lymphocytes. Gynecol Oncol 49(3): 291–298

    Article  CAS  PubMed  Google Scholar 

  • Costanzo ES, Lutgendorf SK, Sood AK, Anderson B, Sorosky J, Lubaroff DM (2005) Psychosocial factors and interleukin- 6 among women with advanced ovarian cancer. Cancer 104: 305–313

    Article  PubMed  Google Scholar 

  • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420: 860–867

    Article  CAS  PubMed  Google Scholar 

  • Fawzy FI, Fawzy NW, Hyun CS, Elashoff R, Guthrie D, Fahey JL, Morton DL (1993) Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry 50(9): 681–689

    CAS  PubMed  Google Scholar 

  • Fidler IJ (2003) The pathogenesis of cancer metastasis: the ‚seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453–458

    Article  CAS  PubMed  Google Scholar 

  • Fischer JR, Schindel M, Bulzebruck H, Lahm H, Krammer PH, Drings P (1997) Decrease of interleukin-2 secretion is a new independent prognostic factor associated with poor survival in patients with small-cell lung cancer. Ann Oncol 8: 457–461

    Article  CAS  PubMed  Google Scholar 

  • Garzetti G, Cignitti M, Ciavattini A et al. (1993) Natural Killer Cell Activity and Progression-Free Survival in Ovarian Cancer. Gynecol Obstet Invest 35: 118–120

    Article  CAS  PubMed  Google Scholar 

  • Goodwin PJ, Leszcz M, Ennis M (2001)The effect of group psychosocial support on survival in metastatic breast cancer. N Engl J Med 345: 1719–1726

    Article  CAS  PubMed  Google Scholar 

  • Imai K, Matsumaya S, Miyake S, Suga I, Nakachi K (2000) Natural cytotoxic activity of peripheral-blood lymphocytes and cancer incidence, an 11 year follow-up study of a general population. Lancet 356: 1795–1799

    Article  CAS  PubMed  Google Scholar 

  • Jehn CF, Kuehnhardt D, Bartholomae A et al. (2006) Biomarkers of depression in cancer patients. Cancer 107: 2723–2729

    Article  CAS  PubMed  Google Scholar 

  • Kang D, Fox C (2001) Th1 and Th2 cytokine responses to academic stress. Res Nurs Health 24: 245–257

    Article  CAS  PubMed  Google Scholar 

  • Khong HT, Restifo NP (2002) Natural selection of tumor variants in the generation of »tumor escape« phenotypes. Nat Immunol 3: 999–1005

    Article  CAS  PubMed  Google Scholar 

  • Kissane D, Grabsch B, Clarke D (2007) Supportive-expressive group therapy for women with metastatic breast cancer: Survival and psychosocial outcomes from a randomized controlled trial. Psycho-Oncol 16: 277–286

    Article  Google Scholar 

  • Kobilka B (1992) Adrenergic receptors as models for G protein- coupled receptors. Annu Rev Neurosci 15: 87–114

    Article  CAS  PubMed  Google Scholar 

  • Lee J, Shahzad M, Lin Y et al. (2009) Surgical stress promotes tumor growth in ovarian carcinomas. Clin Cancer Res 15: 2695–2702

    Article  PubMed  Google Scholar 

  • Lutgendorf SK, Johnsen EL, Cooper B et al. (2002) Vascular endothelial growth factor and social support in patients with ovarian carcinoma. Cancer 95: 808–815

    Article  CAS  PubMed  Google Scholar 

  • Lutgendorf SK, Cole S, Costanzo E et al. (2003) Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9: 4514–4521

    CAS  PubMed  Google Scholar 

  • Lutgendorf S, Sood AK, Anderson B et al. (2005) Social support, psychological distress, and natural killer cell activity in ovarian cancer. Journal of Clinical Oncology 23: 7105– 7113

    Article  PubMed  Google Scholar 

  • Lutgendorf SK, Weinrib AZ, Penedo F et al. (2008a) Interleukin- 6, Cortisol, and Depressive Symptoms in Ovarian Cancer Patients. J Clin Oncol 26: 4820–4827

    Article  CAS  Google Scholar 

  • Lutgendorf SK, Lamkin DM, Jennings et al. (2008b) Biobehavioral Influences on Matrix Metalloproteinase Expression in Ovarian Carcinoma. Clin Cancer Res 14: 6839–6846

    Article  CAS  Google Scholar 

  • Lutgendorf SK, DeGeest K, Sung CY et al. (2009) Depression, Social Support, and Beta-Adrenergic Transcription Control in Human Ovarian Cancer. Brain Behav Immun 23: 176–183

    Article  CAS  PubMed  Google Scholar 

  • McEwen BS (2007) Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87: 873– 904

    Article  PubMed  Google Scholar 

  • McGregor B, Antoni MH (2009) Psychological intervention and health outcomes among women treated for breast cancer: a review of stress pathways and biological mediators. Brain Behav Immun 23:159–166

    Article  CAS  PubMed  Google Scholar 

  • Menard JY, Blay C, Borg S et al. (2009) Natural killer cell IFNgamma levels predict long-term survival with imatinib mesylate therapy in gastrointestinal stromal tumor-bearing patients. Cancer Res 69: 3563–3569

    Article  CAS  PubMed  Google Scholar 

  • Miller J, Tessmer-Tuck J, Pierson B et al. (1997) Low dose subcutaneous interleukin-2 after autologous transplantation generates sustained in vivo natural killer cell activity. Biological Blood Marrow Transplantation 3: 34–44

    CAS  Google Scholar 

  • Moran TJ, Gray S, Mikosz CA, Conzen SD (2000) The glucocorticoid receptor mediates a survival signal in human mammary epithelial cells. Cancer Res 60: 867–872

    CAS  PubMed  Google Scholar 

  • Nelson E, Wenzel L, Osann K et al. (2008) Stress, immunity and cervical cancer: biobehavioral outcomes of a randomized clinical trial. Clin Cancer Res 14, 27: 2111–2118

    Article  PubMed  Google Scholar 

  • Newell, S, Sanson-Fisher, R, Savolainen, N (2002) Systematic review of psychological therapies for cancer patients: Overview and recommendations for future research. J NCI 94: 558–584

    Google Scholar 

  • Nilsson MB, Armaiz-Pena G, Takahashi R et al. (2007) Stress hormones regulate IL-6 expression by human ovarian carcinoma cells through a SRC-dependent mechanism. J Biol Chem 282: 29919–29926

    Article  CAS  PubMed  Google Scholar 

  • Pang D, Kocherginsky M, Krausz T, Kim SY, Conzen SD (2006) Dexamethasone decreases xenograft response to Paclitaxel through inhibition of tumor cell apoptosis. Cancer Biol Ther 5: 933–940

    Article  CAS  PubMed  Google Scholar 

  • Phillips RE (2002) Immunology taught by Darwin. Nat Immunol 3: 987–989

    Article  CAS  PubMed  Google Scholar 

  • Pollard JW (2004) Tumour-educated macrophages promote tumour progression and metastasis. Nature Reviews Cancer 4: 71–78

    Article  CAS  PubMed  Google Scholar 

  • Rohleder N, Wolf J, Kirschbaum C (2003) Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects. Stress 6: 207–222

    Article  CAS  PubMed  Google Scholar 

  • Roussel E, Gingras MC, Grimm EA, Bruner JM, Moser RP (1996) Predominance of a type 2 intratumoral immune response in fresh tumour-infiltrating lymphocytes from human gliomas. Clin Exp Immunol 105: 344

    Article  CAS  PubMed  Google Scholar 

  • Schantz SP, Goepfert H (1987) Multimodality therapy and distant metastases. The impact of natural killer cell activity Arch Otolaryngol Head Neck Surg 113(11): 1207–1213

    CAS  Google Scholar 

  • Sephton S, Sapolsky RM, Kraemer HC, Speigel D (2000) Early mortality in metastatic breast cancer patients with absent of abnormal diurnal cortisol rhythms. J Nat Cancer Inst 92: 994–1000

    Article  CAS  PubMed  Google Scholar 

  • Sephton SE, Dhabhar FS, Keuroghlian AS et al. (2009) Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer. Brain Behav Immun Jul 28

    Google Scholar 

  • Sood AK, Bhatty R, Kamat AA et al. (2006) Stress hormone mediated invasion of ovarian cancer cells. Clin Cancer Res 12: 369–375

    Article  CAS  PubMed  Google Scholar 

  • Spannuth WA, Sood AK, Coleman RL (2008) Angiogenesis as a strategic target for ovarian cancer therapy. Nat Clin Pract Oncol 5: 194–204

    Article  CAS  PubMed  Google Scholar 

  • Spiegel D, Bloom JR, Kraemer HC, Gottheil E (1989) Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet 2(8668): 888–891

    Article  CAS  PubMed  Google Scholar 

  • Spiegel D, Butler LD, Giese-Davis J et al. (2007) Effects of Supportive- Expressive Group Therapy on Survival of Patients with Metastatic Breast Cancer: A Randomized Prospective Trial. Cancer 110: 1130

    Article  PubMed  Google Scholar 

  • Stefanek M, Palmer S, Thombs B, Coyne J (2009) Finding what there is not: Unwarranted claims of an effects of psychosocial intervention on recurrence and survival. Cancer 115: 5612–5616

    Article  PubMed  Google Scholar 

  • Subleski J, Wiltrout R, Weiss J (2009) Application of tissuespecific NK and NKT cell activity for tumor immunotherapy. J of Autoimmunity 33: 275–281

    Article  CAS  Google Scholar 

  • Tartour E, Gey A, Sastre-Garau X, Lombard SI, Mosseri V, Fridman WH (1998) Prognostic value of intratumoral interferon gamma messenger RNA expression in invasive cervical carcinomas. J Natl Cancer Inst 90: 287–294

    Article  CAS  PubMed  Google Scholar 

  • Thornton L, Andersen B, Carson W (2008) Immune, endocrine, and behavioral precursors to breast cancer recurrence: a case-control analysis. Cancer Immunol Immunother 57: 1471–1481

    Article  CAS  PubMed  Google Scholar 

  • Thornton L, Andersen B, Scholer T, Carson W (2009) A psychological intervention reduces inflammatory markers by alleviating depressive symptoms: secondary analysis of a randomized controlled trial. Psychosomatic Medicine 71: 715–724

    Article  CAS  PubMed  Google Scholar 

  • Tsutsui S, Yasuda K, Suzuki K, Tahara K, Higashi H, Era S (2005) Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol Rep 14: 425–431

    CAS  PubMed  Google Scholar 

  • Trinchieri G, Scott P (1995) Interleukin-12: a proinflammatory cytokine with immunoregulatory functions. ResImmunol 146: 423–431

    CAS  Google Scholar 

  • Turner-Cobb JM, Sephton SE, Koopman C, Blake-Mortimer J, Spiegel D (2000) Social support and salivary cortisol in women with metastatic breast cancer. Psychosom Med 62: 337–345

    CAS  PubMed  Google Scholar 

  • Yamasaki S, Kan N, Harada T et al. (1993) Relationship between immunological parameters and survival of patients with liver metastases from breast cancer given immuno-chemotherapy. Breast Cancer Res Treat 26(1): 55–65

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Antoni, M.H., Lutgendorf, S. (2011). Psychoendokrinologie und Psychoimmunologie in der Onkologie. In: Ehlert, U., von Känel, R. (eds) Psychoendokrinologie und Psychoimmunologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16964-9_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-16964-9_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-16963-2

  • Online ISBN: 978-3-642-16964-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics