Abstract
Acute disseminated encephalomyelitis (ADEM) is an autoimmune inflammatory and demyelinating disease of the CNS. Although the mechanism by which demyelination occurs is unclear, several theories have been suggested. In approximately 50–75% of cases, symptoms arise 4–15 days after an upper respiratory tract infection or after vaccination.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsFurther Reading
Books
Atlas SW (2004) RM de cabeza y columna. Ed. Marban, Madrid
Barkovich JA (2005) Pediatric neuroimaging. Lippincott Williams & Wilkins, Philadeplphia, PA
Cinalli G, Maixner WJ, Sainte-Rose C (ed) (2005) Pediatric hydrocephalus, vol 27. Springer, Milan pp 397–405
Harrison (2010) Principios de medicina interna. 17º edición, vol II. Ed. Interamericana McGraw-Hill, p 2308
Ketonen LM, Hiwatashi A, Sidhu R, Westesson P-L (2005) Pediatric brain and spine. An atlas of MRI and spectroscopy, vol 4. Springer, New York, pp 160–161
Mann I (1957) Abnormalities affecting the eye as a whole. In: Mann I (ed) Developmental abnormalities of the eye. Lippincott, Philadelphia, PA, pp 60–66
Mukherji CM (1996) Imaging of the pediatric head, neck and spine. Lippincott-Raven, Philadelphia, PA, 17.12,698
Osborn A et al (2004a) Diagnostic imaging: Brain. AMIRSYS, Salt Lake City, UT
Osborn A et al (2004) Diagnostic imaging: brain. Amirsys, Salt Lake City, UT, 10: I-10-24
Raine CS (2000) Esclerosis múltiple. Bases clínicas y patogénicas. ISBN: 84-7714-186-X, 2000. Editores Médicos S.A
Web Link
Articles
Abdel Razek et al (2009) Disorders of cortical formation: MR imaging features. AJNR Am J Neuroradiol 30:4–11
Ahn KJ, You WJ, Jeong SL, Lee JW, Kim BS, Lee JH et al (2004) Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping. Neuroradiology 46:978–983
Albernaz VS, Castillo M, Hudgins PA, Mukherji SK (1997) Imaging findings in patients with clinical anophtalmos. AJNR Am J Neuroradiol 18:555–561
Alehan F, Erol I, Agildere AM, Ozcay F, Baskin E, Cengiz N et al (2007) Posterior leukoencephalopathy syndrome in children and adolescents. J Child Neurol 22:406–413
Arend WP, Michel BA, Bloch DA, Hunder GG, Calabrese LH, Edworthy SM et al (1990) The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 33:1129–1134
Auletta J, John CC (2001) Spinal epidural abscesses in children: A 15 year experience and review of the literature. Clin Infect Dis 32:9–16
Bair-Merrit M, Chung C, Collier A (2000) Spinal epidural abscess in a young child. Pediatrics 106(3):E39
Bakshi R, Thompson AJ, Rocca MA, Pelletier D, Dousset V, Barkhof F et al (2008) MRI in multiple sclerosis: current status and future prospects. Lancet Neurol 7:615–625
Bargalló N, Olondo L, García AI, Capurro S, Caral L, Rumia J (2005) Functional analysis of third ventriculostomy patency by quantification of CSF stroke volume by using cine phase-contrast MR imaging. AJNR Am J Neuroradiol 26:2514–2521
Bernaerts A, Vanhoenacker FM, Parizel PM, Van Goethem JW, Van Altena R, Laridon A et al (2003) Tuberculosis of the central nervous system: overview of neuroradiological findings. Eur Radiol 13:1876–1890
Bilaniuk LT, Farber M (1992) Imaging of developmental anomalies of the eye and the orbit. AJNR Am J Neuroradiol 13:793–804
Bilginer B, Oguz KK, Akalan N (2009) Endoscopic third ventriculostomy for malfunction in previously shunted infants. Childs Nerv Syst 25:683–688
Blumberg HM, Burman WJ, Chaisson RE, Daley CL, Etkind SC, Friedman LN et al (2003) American Thoracic Society/Centers for Disease Control and Prevention/Infectious Diseases Society of America: treatment of tuberculosis. Am J Respir Crit Care Med 167:603–662
Bronen RA, Vives KP, Kim JH, Fulbright RK, Spencer SS, Spencer DD (1997) Focal cortical dysplasia of Taylor, ballon cell subtype: MR differentiation from low grade tumors. AJNR Am J Neuroradiol 18:1141–1151
Callen DJ, Shroff MM, Branson HM, Li DK, Lotze T, Banwell DS (2009) Role of MRI in the differentiation of ADEM from MS in children. Neurology 72:968–973
Casey SO, Sampaio RC, Michel E, Truwit CL (2000) Posterior reversible encephalopathy syndrome: utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol 21:1199–1206
Chan KH, Cheung RT, Fong CY et al (2003) Clinical releance of hydrocephalus as a presenting feature of tuberculous meningitis. QJM 96:643–648
Chan KH, Cheung RT, Lee R, Mak W, Ho SL (2005) Cerebral infarcts complicating tuberculous meningitis. Cerebrovasc Dis 19:391–395
Chaudhry IA, Arat YO, Shamsi FA, Boniuk M (2004) Congenital microphthalmos with orbital cysts: distinct diagnostic features and management. Ophthal Plast Reconstr Surg 20:452–457
Chavhan GB, Babyn PS, Jankharia BG, Cheng Hai-Ling M, Shroff MM (2008) Steady-state MR imaging sequences: physics, classification, and clinical applications. Radiographics 28:1147–1160
Chen WC, Wang JL, Wang JT, Chen YC, Chang SC (2008) Spinal epidural abscess due to Staphylococcus aureus: clinical manifestations and outcomes. J Microbiol Immunol Infect 41:215–221
Colliot O et al (2006) Individual voxel-based analysis of gray matter in focal cortical dysplasia. Neuroimage 29:162–171
Colombo N et al (2003) Focal cortical dysplasias: MR imaging, histopathologic and clinical correlations in surgically treated patients with epilepsy. AJNR Am J Neuroradiol 24:724–733
Covarrubias DJ, Luetmer PH, Campeau NG (2002) Posterior reversible encephalopathy syndrome: prognostic utility of quantitative diffusion-weighted MR images. AJNR Am J Neuroradiol 23:1038–1048
Dale RC, De Sousa C, Chong WK, Cox TC, Harding B, Neville BG (2000) Acute disseminated encephalomyelitis, multiphasic disseminated encephalomyelitis and multiple sclerosis in children. Brain 123:2407–2422
Dale RC, Brilot F, Banwell B (2009) Pediatric central nervous system inflammatory demyelination: acute disseminated encephalomyelitis, clinically isolated syndromes, neuromyelitis optica, and multiple sclerosis. Curr Opin Neurol 22:233–240
Daxecker F, Felber S (1993) Magnetic resonance imaging features of congenital anophtalmia. Ophtalmologica 206:139–142
Di Carlo P, Cabibi D, Casuccio A, Mazzola A, Romano A, Titone L et al (2008) Features in tubercular meningoencephalitis diagnosis: 18 childhood cases. Am J Infect Dis 4:187–192
Donmez FY, Aslan H, Coskun M (2009) Evaluation of possible prognostic factors of fulminant acute disseminated encephalomyelitis (ADEM) on magnetic resonance imaging with fluid-attenuated inversion recovery (FLAIR) and diffusion-weighted imaging. Acta Radiol 50(3):334–339
Doris D et al (2003) Proton MR spectroscopy in the diagnostic evaluation of suspected mitochondrial disease. AJNR Am J Neuroradiol 22:33–41
Druhan SM, Shiels WE, Kang DR, Elton SW, Koranyi K (2006) Successful sonographically guided drainage of epidural abscess. AJR Am J Roentgenol 187:512–514
Duchowny M (2009) Et al Clinical, functional, and neurophysiologic assessment of dysplastic cortical networks: implications for cortical functioning and surgical management. Epilepsia 50:19–27
Enberg RN, Kaplan RJ (1974) Spinal epidural abscess in children:early diagnosis and inmediate surgical drainage is essential to forestall paralysis. Clin Pediatr 13:247–253
Farinha NJ, Razali KA, Holzel H, Morgan G, Novelli VM (2000) Tuberculosis of the central nervous system in children: a 20-year survey. J Infect 41:61–68
Filippi M (2008) Multiple sclerosis, Part I: Background and conventional MRI. Preface. Neuroimaging Clin N Am 18:XV–XVI
Fischer EG, Greene CS, Winston KR (1981) Spinal epidural abscess in children. Neurosurgery 9:257–260
Fok W, Sun L, Wong N, Lau P, Cheung H (2007) Spontaneous spinal epidural haematoma in a 15-month-old boy presenting with a wry neck: a case report. J Orthop Surg (Hong Kong) 15:373–375
Goto Y, hoarai S, Matsuoka T et al (1992) Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation. Neurology 42:545–550
Gotway MB, Araoz PA, Macedo TA, Stanson AW, Higgins ChB, Ring EJ et al (2005) Imaging findings in Takayasu´s arteritis. AJR Am J Roentgenol 184:1945–1950
Gundlach KK, Guthoff RF, Hingst VH, Schittkowski MP, Bier UC (2005) Expansion of the socket and orbit for congenital clinical anophthalmia. Plat Reconstr Surg 116:1214–1222
Hailong F, Guangfu H, Haibin T, Hong P, Yong C, Weidong L, Dongdong Z (2008) Endoscopic third ventriculostomy in the management of communicating hydrocephalus: a preliminary study. J Neurosurg 109:923–930
Hoffmann M, Corr P, Robbs J (2000) Cerebrovascular findings in Takayasu disease. J Neuroimaging 10:84–90
Honkaniemi J, Dastidar P, Kähärä V, Haapasalo H (2001) Delayed MR imaging changes in acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 22:1117–1124
Hopper K, Sherman JL, Boal DK, Eggli KD (1992) CT and MR imaging of the pediatric orbit. Radiographics 12:485–503
Huynh W, Cordato DJ, Kehdi E, Masters LT, Dedousis C (2008) Post-vaccination encephalomyelitis: literature review and illustrative case. J Clin Neurosci 15:1315–1322
Inglese M, Salvi F, Lannucci G, Mancardi GL, Mascalchi M, Filippi M (2002) Magnetization transfer and diffusion tensor MR imaging of acute disseminated encephalomyelitis. AJNR Am J Neuroradiol 23:267–272
Jacobsen FS, Sullivan B (1994) Spinal epidural abscess in children. Orthopedics 17:1131–1134
Jones BP, Ganesan V, Saunders DE, Chong WK (2010) Imaging in childhood arterial ischaemic stroke. Neuroradiology 52:577–589
Kaltreider SA (2000) The ideal ocular prosthesis: analysis of prosthetic volume. Ophthal Plast Reconstr 16:388–392
Kaltreider SA, Jacobs JL, Hughes MO (1999) Predicting the ideal implant size before enucleation. Ophthal Plast Reconstr 15:37–43
Katrak SM, Shembalkar PK, Bijwe SR, Bhandarkar LD (2000) The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human inmunodeficiency virus infection. J Neurol Sci 181:118–126
Kiminobu Y et al (2001) Diffusion-weighted MR imaging in a case of mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes. AJNR Am J Neuroradiol 22:269–272
Klimo P, Goumnerova LC (2006) Endoscopic third ventriculocisternotomy for brainstem tumors. J Neurosurg 105:271–274
Kwon S, Koo J, Lee S (2001) Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Pediatr Neurol 24:361–364
Lamy C, Oppenheim C, Méder JF, Mas JL (2004) Neuroimaging in posterior reversible encephalopathy syndrome. J Neuroimaging 14:89–96
Lee VH, Wijdicks EF, Manno EM, Rabinstein AA (2008) Clinical spectrum of reversible posterior leukoencephalopathy syndrome. Arch Neurol 65:205–210
Lipina R, Reguli S, Dolezilová V, Kucíková M, Podesvová H (2008) Endoscopic third ventriculostomy for obstructive hydrocephalus in children younger than 6 months of age: is it a first-choice method? Childs Nerv Syst 24:1021–1027
Martínez-León MI (2002) Microftalmía quística bilateral: ojo quístico clínico. Radiología 44(1):41–42
Matsunaga N, Hayashi K, Sakamoto I, Matsuoka Y, Ogawa Y, Honjo K et al (1998) Takayasu arteritis: MR manifestations and diagnosis of acuete and chronic phase. J Magn Reson Imaging 8:406–414
Miller DH, Grossman RI, Reingold SC, McFarland HF (1998) The role of magnetic resonance techniques in understanding and managing multiple sclerosis. Brain 121:3–24
Mukherjee P, McKinstry RC (2001) Reversible posterior leukoencephalopathy syndrome: evaluation with diffusion-tensor MR imaging. Radiology 219:756–765
Nastri MV, Baptista LP, Baroni RH, Blasbalg R, de Avila LF, Leite CC et al (2004) Gadolinium-enhanced three-dimensional MR angiography of Takayasu arteritis. Radiographics 24:773–786
O Brien DF, Seghedoni A, Collins DR, Hayhurst C, Mallucci CL (2006) Is there an indication for ETV in young infants in aetiologies other than isolated aqueduct stenosis? Childs Nerv Syst 22:1565–1572
Oberhansli C, Charles-Messance D, Munier F, Spahn B (2003) Management of microphthalmos and anophthalmos: prosthetic experience. Klin Monatsbl Augenheilkd 220:134–137
Offenbacher H, Fazekas F, Schmidt R, Kleinert R, Payer F, Kleinert G et al (1991) MRI in tuberculous meningoencephalitis: report or four cases and review of the neuroimaging literature. J Neurol 238:340–344
Ozates M, Kemaloglu S, Gurkan F, Ozkan U, Hosoglu S, Simsek MM (2000) CT of the brain in tuberculous meningitis. A review of 289 patients. Acta Radiol 41:13–17
Palmini A, Najm I, Avanzini G et al (2004) Terminology and classification of the cortical dysplasias. Neurology 62:S2–S8
Phelan JA et al (2008) Pediatric neurodegenerative white matter processes: leukodystrophies and beyond. Pediatr Radiol 38:729–749
Poser CM, Paty DW, Scheinberg L, McDonald WI, Davis FA, Ebers GC et al (1983) New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 13:227–331
Provenzale JM, Petrella JR, Cruz LC Jr, Wong JC, Engelter S, Barboriak DP (2001) Quantitative assessment of diffusion abnormalities in posterior reversible encephalopathy syndrome. AJNR Am J Neuroradiol 22:1455–1461
Rajan J, Kannan K, Kesavadas C, Thomas B (2009) Focal Cortical Dysplasia (FCD) lesion analysis with complex diffusion approach. Comput Med Imaging Graph 33:553–558
Ranasuriya DG, Feld RJ, Nairn SJ (2008) A case of acute disseminated encephalomyelitis in a 12-year-old boy. Pediatr Emerg Care 24(10):697–699
Rastorgi S, Lee Ch, Salamon N (2008) Neuroimaging in pediatric epilepsy: a multimodality approach. Radiographics 28:1079–1095
Ringleb PA, Strittmatter EI, Loewer M, Hartmann M, Fiebach JB, Weber R et al (2005) Cerebrovascular manifestations of Takayasu arteritis in Europe. Rheumatology (Oxford) 44:1012–1015
Río J, Rovira A, Tintoré M, Huerga E, Nos C, Tellez N et al (2008) Relationship between MRI lesion activity and response to IFN-beta in relapsing-remitting multiple sclerosis patients. Mult Scler 14:479–484
Ros-Lopez B, Jaramillo-Dallimonti AM, de Miguel-Puello LS, Rodríguez-Barceló S, Domínguez Páez M, Ibáñez-Botella G et al (2009) Ventricular haemorrhage in preterm neonates and posthemorrhagic hydrocephalus. Proposal of a management protocol based on early ventriculo-peritoneal shunt. Neurocirugía 20:15–24
Rossi A (2008) Imaging of acute disseminated encephalomyelitis. Neuroimaging Clin N Am 18:149–161
Rovira A, Swanton J, Tintoré M, Huerga E, Barkhof F, Filippi M et al (2009) A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis. Arch Neurol 66:587–592
Rubin G, Michowiz SD, Ashkenasi A, Tadmor R, Rappaport ZH (1993) Spinal epidural abscess in the pediatric age group:case report and review of the literature. Pediatr Infect Dis J 12:1007–1011
Ryutarou U, Kushihashi T, Tanaka E, Baba M, Usi N, Fujisawa H et al (2006) Diffusion-weighted MR imaging of early-stage Creutzfeldt-Jakob disease: typical and atypical manifestations. Radioraphics 26:S191–S194
Saenz RC (2005) The disappearing basal ganglia sign. Radiology 234:242–243
Scaglia F et al (2005) Predominant cerebellar volume loss as a neuroradiologic feature of pediatric respiratory chain defects. AJNR Am J Neuroradiol 26:1675–1680
Schlaug G, Diewert B, Benfield A, Edelman RR, Warach S (1997) Time course of the apparent diffusion coefficient (ACD) abnormality in human stroke. Neurology 49:113–119
Schmidt WA, Nerenheim A, Seipelt E, Poehls C, Gromnica-Ihle E (2002) Diagnosis of early Takayasu arteritis with sonography. Rheumatology 41:496–502
Schoeman J, Hewlett R, Donald P (1988) MR of childhood tuberculous meningitis. Neuroradiology 30:473–477
Schroff MM, Soares-Fernandez JP, Whyte H, Raybaud C (2010) MR imaging for diagnostic evaluation of encephalopathy in the newborn. Radiographics 30:763–780
Seyfert S, Klapps P, Meísel C, Fisclier T, Junghan U (1990) Multiple sclerosis and other iminunologic diseases. Acta Neurol Scand 81:37–42
Sikaroodi H, Motamedi M, Kahnooji H, Gholamrezanezhad A, Yousefi N (2007) Stroke as the first manifestation of Takayasu Arteritis. Acta Neurol Belg 107:18–21
Stingh I, Haris M, Husain M, Husain N, Rastogi M, Gupta RK (2008) Role of endoscopic third ventriculostomy in patients with communicating hydrocephalus: an evaluation by MR ventriculography. Neurosurg Rev 31:319–325
Stivaros SM, Sinclair D, Bromiley PA, Kim J, Thorne J, Jackson A (2009) Endoscopic third ventriculostomy: predicting outcome with phase-contrast MR imaging. Radiology 252:825–832
Stott VL, Hurrell MA, Anderson TJ (2005) Reversible posterior leukoencephalopathy syndrome: a misnomer reviewed. Intern Med J 35:83–90
Sue CM et al (1998) Neuroradiological features of six kindreds with MELAS tRNALeu A3243G point mutation: implications for pathogenesis. J Neurol Neurosurg Psychiatry 65:233–240
Tassil L, Colombo N, Garbelli R et al (2002) Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain 125:1719–1732
Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34:369–387
Tenembaum S, Chitnis T, Ness J, Hahn JS (2007) Acute disseminated encephalomyelitis. Neurology 17(68):S23–S36
Traboulsee AL, Li DK (2006) The role of MRI in the diagnosis of multiple sclerosis. Adv Neurol 98:125–146
Tur C, Téllez N, Rovira A, Tintoré M, Río J, Nos C et al (2008) Acute disseminated encephalomyelitis: study of factors involved in a possible development towards multiple. Neurologia 23(9):546–554
Walter RS, King JC, Manley J, Rigamonti D (1991) Spinal epidural abscess in infancy:successful percutaneous drainage in a nine-month-old and review of the literature. Pediatr Infect Dis J 10:860–864
Yamada I, Numano F, Suzuki S (1993) Takayasu arteritis: evaluation with MR imaging. Radiology 188:89–94
Zivadinov R, Cox JL (2007) Neuroimaging in multiple sclerosis. Int Rev Neurobiol 79:449–474
Acknowledgment
Acknowledgment to Dr. Raj Palani for his help on the preparation of this case.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
León, M.I.M., Gutiérrez, J.E., Ruiz, L.C. (2011). Non-tumoral Neurology. In: Learning Pediatric Imaging. Learning Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16892-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-642-16892-5_3
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16891-8
Online ISBN: 978-3-642-16892-5
eBook Packages: MedicineMedicine (R0)