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p53, a Molecular Bridge Between Alzheimer’s Disease Pathology and Cancers?

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Two Faces of Evil: Cancer and Neurodegeneration

Part of the book series: Research and Perspectives in Alzheimer's Disease ((ALZHEIMER))

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Abstract

Cancers are characterized by enhanced cell survival and altered differentiation processes whereas Alzheimer’s disease (AD)-affected brains exhibit exacerbated neuronal loss and cell death. Interestingly, several studies have consistently reported on an inverse relationship between cancer and AD. On the other hand, p53, a tumor-suppressor oncogene, is mutated and inactivated in a majority of human cancers; conversely, several lines of evidence concur to suggest an elevation of p53 and its transcriptional targets in AD brains. Therefore, one could envision p53 as a molecular bridge between cancer and AD pathologies. Although the role of p53 in cancer likely results from its inactivation by somatic mutations, the mechanistic aspects underlying a dysfunction in the control of p53 in AD had not been delineated. Here we survey recent evidence that p53 could control and be controlled by several members of the presenilin-dependent γ-secretase complex, and we briefly discuss the possibility that a functional deficit in presenilins could contribute to the genesis of a subset of tumors.

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Authors and Affiliations

  1. IPMC and IN2M, UMR6097 CNRS/UNSA, Team Fondation pour la Recherche Médicale, Sophia-Antipolis, Valbonne, 06560, France

    Frédéric Checler

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  1. Frédéric Checler
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  2. Julie Dunys
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  3. Raphaëlle Pardossi-Piquard
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  4. Cristine Alves da Costa
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Correspondence to Frédéric Checler .

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Editors and Affiliations

  1. , Department of Pathology and Laboratory M, The Children's Hospital of Philadelphia, Civic Center Boulevard 3501, Philadelphia, 19104, Pennsylvania, USA

    Thomas Curran

  2. Fondation IPSEN, Quai Georges Gorse 65, Boulogne-Billancourt Cedex, 92650, France

    Yves Christen

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Checler, F., Dunys, J., Pardossi-Piquard, R., Costa, C.A.d. (2011). p53, a Molecular Bridge Between Alzheimer’s Disease Pathology and Cancers?. In: Curran, T., Christen, Y. (eds) Two Faces of Evil: Cancer and Neurodegeneration. Research and Perspectives in Alzheimer's Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16602-0_8

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